Cause-Specific Mortality in Patients During Long-Term Follow-Up After Atrial Switch for Transposition of the Great Arteries

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Cause-Specific Mortality in Patients During Long-Term Follow-Up After Atrial Switch for Transposition of the Great Arteries

Schophuus Jensen, Annette (author): Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark.

Højsgaard Jørgensen, Troels (author): Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark.

Christersson, Christina (author): Uppsala universitet,Kardiologi

Nagy, Edit (author): Department of Medicine, Heart and Vascular Theme, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Univ Hosp, Karolinska Inst, Dept Med Heart & Vasc Theme, Stockholm, Sweden.

Sinisalo, Juha (author): Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland; Helsinki University, Helsinki, Finland,Helsinki Univ Cent Hosp, Heart & Lung Ctr, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.

Furenäs, Eva (author): Department of Cardiology, Sahlgrenska Academy, University of Göteborg, Gothenburg, Sweden,Univ Göteborg, Sahlgrenska Acad, Dept Cardiol, Gothenburg, Sweden.

Gjesdal, Ola (author): Department of Cardiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Norway,Oslo Univ Hosp, Rikshosp, Dept Cardiol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.

Eriksson, Peter (author): Department of Cardiology, Sahlgrenska Academy, University of Göteborg, Gothenburg, Sweden,Univ Göteborg, Sahlgrenska Acad, Dept Cardiol, Gothenburg, Sweden.

Vejlstrup, Niels (author): Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark.

Johansson, Bengt (author): Umeå universitet,Klinisk fysiologi,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.

Hlebowicz, Joanna (author): Department of Cardiology, Lund University Hospital, Lund, Sweden,Lund Univ Hosp, Dept Cardiol, Lund, Sweden.

Greve, Gottfried (author): Department of Cardiology, Haukeland University Hospital, Bergen, Norway,Haukeland Hosp, Dept Cardiol, Bergen, Norway.

Dellborg, Mikael (author): Department of Cardiology, Sahlgrenska Academy, University of Göteborg, Gothenburg, Sweden,Univ Göteborg, Sahlgrenska Acad, Dept Cardiol, Gothenburg, Sweden.

Skulstad, Helge (author): Department of Cardiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Norway,Oslo Univ Hosp, Rikshosp, Dept Cardiol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.

Kvidal, Per (author): Uppsala universitet,Institutionen för medicinska vetenskaper

Jokinen, Eero (author): Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland; Helsinki University, Helsinki, Finland,Helsinki Univ Cent Hosp, Heart & Lung Ctr, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.

Sairanen, Heikki (author): Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland; Helsinki University, Helsinki, Finland,Helsinki Univ Cent Hosp, Heart & Lung Ctr, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.

Thilén, Ulf (author): Department of Cardiology, Lund University Hospital, Lund, Sweden,Lund Univ Hosp, Dept Cardiol, Lund, Sweden.

Søndergaard, Lars (author): Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark.

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Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark (creator_code:org_t)

American Heart Association, 2022
2022
English.
In: Journal of the American Heart Association. - : American Heart Association. - 2047-9980 .- 2047-9980. ; 11:14

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

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BACKGROUND: Little is known about the cause of death (CoD) in patients with transposition of the great arteries palliated with a Mustard or Senning procedure. The aim was to describe the CoD for patients with the Mustard and Senning procedure during short-(<10 years), mid-(10–20 years), and long-term (>20 years) follow-up after the operation.METHODS AND RESULTS: This is a retrospective, descriptive multicenter cohort study including all Nordic patients (Denmark, Finland, Norway, and Sweden) who underwent a Mustard or Senning procedure between 1967 and 2003. Patients who died within 30 days after the index operation were excluded. Among 968 patients with Mustard/Senning palliated transposition of the great arteries, 814 patients were eligible for the study, with a mean follow-up of 33.6 years. The estimated risk of all-cause mortality reached 36.0% after 43 years of follow-up, and the risk of death was highest among male patients as compared with female patients (P=0.004). The most common CoD was sudden cardiac death (SCD), followed by heart failure/heart transplantation accounting for 29% and 27%, respectively. During short-, mid-, and long-term follow-up, there was a change in CoD with SCD accounting for 23.7%, 46.6%, and 19.0% (P=0.002) and heart failure/heart transplantation 18.6%, 22.4%, and 46.6% (P=0.0005), respectively.CONCLUSIONS: Among patients corrected with Mustard or Senning transposition of the great arteries, the most common CoD is SCD followed by heart failure/heart transplantation. The CoD changes as the patients age, with SCD as the most common cause in adolescence and heart failure as the dominant cause in adulthood. Furthermore, the risk of all-cause mortality, SCD, and death attributable to heart failure or heart transplantation was increased in men >10 years after the Mustard/Senning operation.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Journal of the A ...

By the university: Umeå University; Uppsala University; Karolinska Institutet

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Cause-Specific Mortality in Patients During Long-Term Follow-Up After Atrial Switch for Transposition of the Great Arteries

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