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Sökning: WFRF:(Velicko Inga)

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1.
  • Herrmann, Björn, et al. (författare)
  • Emergence and Spread of Chlamydia trachomatis Variant, Sweden
  • 2008
  • Ingår i: Emerging Infectious Diseases. - 1080-6040 .- 1080-6059. ; 14:9, s. 1462-1465
  • Tidskriftsartikel (refereegranskat)abstract
    • A variant of Chlamydia trachomatis that had escaped detection by commonly used systems was discovered in Sweden in 2006. In a nationwide study, we found that it is now prevalent across Sweden, irrespective of the detection system used. Genetic analysis by multilocus sequence typing identified a predominant variant, suggesting recent emergence.
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2.
  • Velicko, Inga, et al. (författare)
  • Sexual and testing behaviour associated with Chlamydia trachomatis infection : a cohort study in an STI clinic in Sweden
  • 2016
  • Ingår i: ; 6:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Genital chlamydia infection (chlamydia) is the most commonly reported sexually transmitted infection (STI) in Sweden. To guide prevention needs, we aimed to investigate factors associated with chlamydia. Methods: A cohort of visitors aged 20-40 years at an urban STI clinic in Sweden was recruited. Behavioural data were collected using a self-administered questionnaire. Self-sampled specimens were tested for chlamydia by a DNA amplification assay. Statistically significant (p<0.05) and epidemiologically relevant covariates were entered in a multivariate Poisson model adjusted for potential confounders (age and gender). Backward stepwise elimination produced a final model. Multiple imputation was used to account for missing values. Results: Out of 2814 respondents, 1436 were men with a chlamydia positivity rate of 12.6% vs 8.9% in women. Lifetime testing for chlamydia and HIV was high (82% and 60%, respectively). Factors significantly associated with chlamydia were: 20-24 years old (adjusted risk ratio (ARR)=2.10, 95% CI 1.21 to 3.65); testing reason: contact with a chlamydia case (ARR=6.55, 95% CI 4.77 to 8.98) and having symptoms (ARR=2.19, 95% CI 1.48 to 3.24); 6-10 sexual partners (ARR=1.53, 95% CI 1.06 to 2.21); last sexual activity 'vaginal sex and oral sex and anal sex and petting' (ARR=1.84, 95% CI 1.09 to 3.10); alcohol use before sex (ARR=1.98, 95% CI 1.10 to 3.57); men with symptoms (ARR=2.09, 95% CI 1.38 to 3.18); tested for chlamydia (ARR=0.72, 95% CI 0.55 to 0.94). Conclusions: Risk factors associated with chlamydia were consistent with previous reports in similar settings and suggest no major changes over time. Increased risk for chlamydia infection associated with high-risk behaviour (eg, alcohol use, increased number of sexual partners) supports the need for behavioural interventions in this population such as promotion of safer sex behaviour (condom use) and testing.
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3.
  • Kader, Manzur, et al. (författare)
  • Time Elapsed from Onset of Symptoms to Diagnosis of Gonorrhoea in Swedish Patients, 1999-2009
  • 2014
  • Ingår i: Asian Journal of Medical Sciences. - Stockholm : Karolinska Institutet, Dept of Clinical Science, Intervention and Technology. - 2091-0576.
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Gonococcal infection remains an important public health problem worldwide. The incidence of reported gonorrhoea cases in Sweden raised by 32%, from 5.9 to 7.8 cases per 100,000 in 2001 to 2008.The aim of this study is to estimate the lag time or time elapsed between onset of symptoms and diagnosis of gonorrhoea, and to identify the factors associated with diagnostic delay in a sample of reported gonorrhoea cases in Sweden. Methods: A retrospective cohort study was conducted using all reported gonorrhoea cases at the Swedish Institute for Communicable Disease Control (SMI) from the time period 1999-2009. Total number of cases included in final analysis was 2161. Descriptive statistics, ANOVA, independent t-test and multiple linear regression analysis were applied for data analysis. Results: The mean lag time between onset of symptoms and diagnosis of gonorrhoea was 12.3 ± 18.8 days. There was a significant association of lag time with sex, region, type of clinics and type of specimen and year of diagnosis. In multivariate analysis with adjusted model, type of specimen was found to have independent effect on lag time and there was a significant interaction observed between region and sex indicating difference between sexes was due to difference in regions. Conclusion: The result of our study revealed a significant delay in establishing a diagnosis in Gonorrhoea patient sample in Sweden. The variables influencing this delay in diagnosis should be addressed to shorten the lag time leading to an early diagnosis and a proper treatment in our patients. However, more research needs to be carried out in this area to better understand the factors at work.
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4.
  • Lytsy, Birgitta, et al. (författare)
  • A case-control study of risk factors for urinary acquisition of Klebsiella pneumoniae producing CTX-M-15 in an outbreak situation in Sweden
  • 2010
  • Ingår i: Scandinavian Journal of Infectious Diseases. - 0036-5548 .- 1651-1980. ; 42:6-7, s. 439-444
  • Tidskriftsartikel (refereegranskat)abstract
    • A retrospective case-control study was initiated at Uppsala University Hospital in 2006 during a major outbreak caused by a Klebsiella pneumoniae strain producing CTX-M-15. To identify risk factors associated with acquisition of the outbreak strain in the urinary tract, 52 case patients with a urine culture positive for the outbreak strain between 1 May and 31 December 2005 were enrolled. Case patients were matched 1:2 with concurrently hospitalized control patients with significant growth of susceptible Escherichia coli in a urine sample. Conditional logistic regression analyses identified hospital stay >/=9 days (odds ratio (OR) 18.8, 95% confidence interval (CI) 5.74-61.2), nasogastric feeding tube (OR 18.0, 95% CI 2.28-142) and diarrhoea (OR 9.62, 95% CI 3.30-28.1) as risk factors with high ORs. The odds of previous use of cephalosporins were 7.58 (95% CI 3.13-18.4) times higher in case patients compared with the controls. Several multivariable models were evaluated to reduce bias from confounding. These models identified prolonged period of hospitalization, diarrhoea, malignancy and antibiotic use as the most important risk factors for acquisition of the outbreak strain, factors that are often found in elderly patients with a poor functional status.
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