Sökning: WFRF:(Velikyan Irina 1966 )
> Eriksson Barbro >
Species differences...
Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
-
Eriksson, Olof (författare)
-
Rosenström, Ulrika (författare)
-
Selvaraju, Ram Kumar (författare)
-
visa fler...
-
Eriksson, Barbro (författare)
-
Velikyan, Irina 1966- (författare)
-
visa färre...
-
(utgivare)
-
(utgivare)
-
visa fler...
-
(utgivare)
-
(utgivare)
-
visa färre...
- 2017
- 2017
- Engelska.
-
Ingår i: Acta Diabetologica. - 0940-5429. ; 54:11, 1039-1045
Abstract
Ämnesord
Stäng
- AIMS: Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were observed. METHODS: -Exendin4 Positron Emission Tomography (PET) in the same species. In vitro, ex vivo, and in vivo data formed the basis for calculating the theoretical in vivo contribution of each pancreatic compartment. RESULTS: -Exendin4. CONCLUSIONS: IPR as well as the exocrine GLP-1R density is the main determinants of the species variability in pancreatic uptake. Thus, the IPR in human is an important factor for assessing the potential of GLP-1R as an imaging biomarker for pancreatic beta cells.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Endocrinology and Diabetes (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Endokrinologi och diabetes (hsv)
Nyckelord
- Animal models
- Beta cell imaging
- Beta cell mass
- Exendin4
- GLP-1R
- Positron emission tomography
Hitta via bibliotek
Till lärosätets databas