| 1. |
- Durán Bosch, Vicente Andrés, 1977, et al.
(författare)
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Compressive imaging in scattering media
- 2015
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Ingår i: Optics Express. - : The Optical Society. - 1094-4087 .- 1094-4087. ; 23:11, s. 14424-14433
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Tidskriftsartikel (refereegranskat)abstract
- One challenge that has long held the attention of scientists is that of clearly seeing objects hidden by turbid media, as smoke, fog or biological tissue, which has major implications in fields such as remote sensing or early diagnosis of diseases. Here, we combine structured incoherent illumination and bucket detection for imaging an absorbing object completely embedded in a scattering medium. A sequence of low-intensity microstructured light patterns is launched onto the object, whose image is accurately reconstructed through the light fluctuations measured by a single-pixel detector. Our technique is noninvasive, does not require coherent sources, raster scanning nor time-gated detection and benefits from the compressive sensing strategy. As a proof of concept, we experimentally retrieve the image of a transilluminated target both sandwiched between two holographic diffusers and embedded in a 6mm-thick sample of chicken breast.
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| 2. |
- Durán Bosch, Vicente Andrés, 1977, et al.
(författare)
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Transillumination imaging through biological tissue by single-pixel detection
- 2015
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Ingår i: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. - : SPIE. - 1605-7422. - 9781628417067 ; 9541, s. Artno 95410B-
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Konferensbidrag (refereegranskat)abstract
- One challenge that has long held the attention of scientists is that of clearly seeing objects hidden by turbid media, as smoke, fog or biological tissue, which has major implications in fields such as remote sensing or early diagnosis of diseases. Here, we combine structured incoherent illumination and bucket detection for imaging an absorbing object completely embedded in a scattering medium. A sequence of low-intensity microstructured light patterns is launched onto the object, whose image is accurately reconstructed through the light fluctuations measured by a single-pixel detector. Our technique is noninvasive, does not require coherent sources, raster scanning nor time-gated detection and benefits from the compressive sensing strategy. As a proof of concept, we experimentally retrieve the image of a transilluminated target both sandwiched between two holographic diffusers and embedded in a 6mm-thick sample of chicken breast.
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| 3. |
- Hueyuek, Tayfun, et al.
(författare)
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Conceptual design of the early implementation of the NEutron Detector Array (NEDA) with AGATA
- 2016
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Ingår i: European Physical Journal A. - : Springer-Verlag New York. - 1434-6001 .- 1434-601X. ; 52:3
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Tidskriftsartikel (refereegranskat)abstract
- The NEutron Detector Array (NEDA) project aims at the construction of a new high-efficiency compact neutron detector array to be coupled with large gamma-ray arrays such as AGATA. The application of NEDA ranges from its use as selective neutron multiplicity filter for fusion-evaporation reaction to a large solid angle neutron tagging device. In the present work, possible configurations for the NEDA coupled with the Neutron Wall for the early implementation with AGATA has been simulated, using Monte Carlo techniques, in order to evaluate their performance figures. The goal of this early NEDA implementation is to improve, with respect to previous instruments, efficiency and capability to select multiplicity for fusion-evaporation reaction channels in which 1, 2 or 3 neutrons are emitted. Each NEDA detector unit has the shape of a regular hexagonal prism with a volume of about 3.23 l and it is filled with the EJ301 liquid scintillator, that presents good neutron-gamma discrimination properties. The simulations have been performed using a fusion-evaporation event generator that has been validated with a set of experimental data obtained in the Ni-58 + Fe-56 reaction measured with the Neutron Wall detector array.
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| 4. |
- López-Isac, Elena, et al.
(författare)
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Brief Report : IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies
- 2016
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Ingår i: Arthritis & Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 68:9, s. 2338-2344
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc–RA loci through an interdisease meta–genome-wide association (meta-GWAS) strategy. Methods: The study was designed as a meta-analysis combining GWAS data sets of patients with SSc and patients with RA, using a strategy that allowed identification of loci with both same-direction and opposite-direction allelic effects. The top single-nucleotide polymorphisms were followed up in independent SSc and RA case–control cohorts. This allowed an increase in the sample size to a total of 8,830 patients with SSc, 16,870 patients with RA, and 43,393 healthy controls. Results: This cross-disease meta-analysis of the GWAS data sets identified several loci with nominal association signals (P < 5 × 10−6) that also showed evidence of association in the disease-specific GWAS scans. These loci included several genomic regions not previously reported as shared loci, as well as several risk factors that were previously found to be associated with both diseases. Follow-up analyses of the putatively new SSc–RA loci identified IRF4 as a shared risk factor for these 2 diseases (Pcombined = 3.29 × 10−12). Analysis of the biologic relevance of the known SSc–RA shared loci identified the type I interferon and interleukin-12 signaling pathways as the main common etiologic factors. Conclusion: This study identified a novel shared locus, IRF4, for the risk of SSc and RA, and highlighted the usefulness of a cross-disease GWAS meta-analysis strategy in the identification of common risk loci.
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| 5. |
- Andres-Martin, Miguel, et al.
(författare)
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Uncertainty in surface wind speed projections over the Iberian Peninsula: CMIP6 GCMs versus a WRF-RCM
- 2023
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Ingår i: Annals of the New York Academy of Sciences. - 0077-8923 .- 1749-6632. ; 1529:1, s. 101-108
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Tidskriftsartikel (refereegranskat)abstract
- This study assessed the projected near-surface wind speed (SWS) changes and variability over the Iberian Peninsula for the 21st century. Here, we compared Coupled Model Intercomparison Project Phase 6 global climate models (GCMs) with a higher spatial resolution regional climate model (RCM; ∼20 km), known as WRF-CESM2, which was created by a dynamic downscaling of the Community Earth System Model version 2 (CESM2) using the Weather Research and Forecasting (WRF) model. Our analysis found that the GCMs tended to overestimate observed SWS for 1985–2014, while the higher spatial resolution of the WRF-CESM2 did not improve the accuracy and underestimated the SWS magnitude. GCMs project a decline of SWS under high shared socioeconomic pathways (SSPs) greenhouse concentrations, such as SSP370 and SSP585, while an interdecadal oscillation appears in SSP126 and SSP245 for the end of the century. The WRF-CESM2 under SSP585 predicts the opposite increasing SWS. Our results suggest that 21st-century projections of SWS are uncertain even for regionalized products and should be taken with caution.
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| 6. |
- Azorin-Molina, Cesar, et al.
(författare)
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Biases in wind speed measurements due to anemometer changes
- 2023
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Ingår i: Atmospheric Research. - 0169-8095. ; 289
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Tidskriftsartikel (refereegranskat)abstract
- This research presents a case study of the biases and discontinuities that were introduced in observed long-term mean wind-speed and gust data-series due to anemometer changes in a meteorological station in northern Spain, operated by the Spanish State Meteorological Agency: San Sebastian-Igueldo. Field and wind-tunnel experiments with predefined conditions have been presented in the literature, however this research uses a real case study to assess the impact of anemometer changes on wind speed measurements due to three factors being: (i) the 3-cup anemometer model (SEAC vs. THIES companies); (ii) sensor height (∼19.95 m vs. ∼20.45 m) and (iii) sensor age (20-years old vs. new). Our results show (a) substantial biases in the measured wind speed and daily peak wind gusts, with the new THIES anemometer reporting stronger surface winds than the old SEAC anemometer; (b) opposing biases under weak (negative) and moderate-strong (positive) winds; and (c) significant breakpoints in the long-term wind data-series, which highlight the importance of data homogenization. National Weather Services and climate assessment groups will benefit from these findings since errors in wind speed and gust measurements can be minimized by implementing systematic observation protocols. Robust anemometer observations provide a basis for accurate quantification of the magnitude of changes and the variability of surface winds.
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| 7. |
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| 8. |
- Chen, Chiu-Yu, et al.
(författare)
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Blood flow reprograms lymphatic vessels to blood vessels.
- 2012
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Ingår i: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 122:6
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Tidskriftsartikel (refereegranskat)abstract
- Human vascular malformations cause disease as a result of changes in blood flow and vascular hemodynamic forces. Although the genetic mutations that underlie the formation of many human vascular malformations are known, the extent to which abnormal blood flow can subsequently influence the vascular genetic program and natural history is not. Loss of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) resulted in a vascular malformation that directed blood flow through mesenteric lymphatic vessels after birth in mice. Mesenteric vessels in the position of the congenital lymphatic in mature Slp76-null mice lacked lymphatic identity and expressed a marker of blood vessel identity. Genetic lineage tracing demonstrated that this change in vessel identity was the result of lymphatic endothelial cell reprogramming rather than replacement by blood endothelial cells. Exposure of lymphatic vessels to blood in the absence of significant flow did not alter vessel identity in vivo, but lymphatic endothelial cells exposed to similar levels of shear stress ex vivo rapidly lost expression of PROX1, a lymphatic fate-specifying transcription factor. These findings reveal that blood flow can convert lymphatic vessels to blood vessels, demonstrating that hemodynamic forces may reprogram endothelial and vessel identity in cardiovascular diseases associated with abnormal flow.
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| 9. |
- Durán Bosch, Vicente Andrés, 1977, et al.
(författare)
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Electro-optic dual-comb interferometer for high-speed vibrometry
- 2017
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Ingår i: Optics Express. - 1094-4087 .- 1094-4087. ; 25:14, s. 16427-16436
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Tidskriftsartikel (refereegranskat)abstract
- © 2017 Optical Society of America. Electro-optic frequency comb generators are particularly promising for dual-comb spectroscopy. They provide a high degree of mutual coherence between the combs without resorting to complex feedback stabilization mechanisms. In addition, electro-optic frequency combs can operate at very high repetition rates, thus providing very fast acquisition speeds. Here, we exploit these two features to resolve the rapid movement of a vibrating target. Our electro-optic dual-comb interferometer is capable of combining time-of-fight information with a more precise interferometric measurement based on the carrier phase. This fact, previously demonstrated by stabilized femtosecond frequency combs, allows us to increase the precision of the time-of-flight measurement by several orders of magnitude. As a proof of concept, we implement a fiber-based vibrometer that offers sub-nanometer precision at an effective acquisition speed of 250 kHz. These results expand the application landscape of electro-optic dual-comb spectroscopy to laser ranging and other remote sensing measurements.
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| 10. |
- Durán Bosch, Vicente Andrés, 1977, et al.
(författare)
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Electro-optic dual-comb interferometry over 40-nm bandwidth
- 2016
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Ingår i: Optics Letters. - 0146-9592 .- 1539-4794. ; 41:18, s. 4190-4193
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Tidskriftsartikel (refereegranskat)abstract
- Dual-comb interferometry is a measurement technique that uses two laser frequency combs to retrieve complex spectra in a line-by-line basis. This technique can be implemented with electro-optic frequency combs, offering intrinsic mutual coherence, high acquisition speed and flexible repetition-rate operation. A challenge with the operation of this kind of frequency comb in dual-comb interferometry is its limited optical bandwidth. Here, we use coherent spectral broadening and demonstrate electro-optic dual-comb interferometry over the entire telecommunications C band (200 lines covering ~ 40 nm, measured within 10 microseconds at 100 signal-to-noise ratio per spectral line). These results offer new prospects for electro-optic dual-comb interferometry as a suitable technology for high-speed broadband metrology, for example in optical coherence tomography or coherent Raman microscopy.
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