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The effect of body ...
The effect of body mass index on overall and disease-free survival in node-positive breast cancer patients treated with docetaxel and doxorubicin-containing adjuvant chemotherapy: the experience of the BIG 02-98 trial
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- de Azambuja, Evandro (author)
- Inst Jules Bordet, B-1000 Brussels, Belgium
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- McCaskill-Stevens, Worta (author)
- NCI, NIH, Bethesda, MD 20892 USA
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- Francis, Prudence (author)
- Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
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- Quinaux, Emmanuel (author)
- Int Inst Drug Dev, Louvain, Belgium
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- Crown, John P A (author)
- St Vincents Hosp, Dublin 4, Ireland
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- Vicente, Malou (author)
- Br EAST Data Ctr, Brussels, Belgium
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- Giuliani, Rosa (author)
- S Camillo Forlanini Hosp, Med Oncol Unit, Rome, Italy
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- Nordenskjöld, Bo (author)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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- Gutierez, Jorge (author)
- Clin Las Condes, Santiago, Chile
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- Andersson, Michael (author)
- Copenhagen Univ Hosp, Rigshosp, Finsen Ctr, Dept Oncol, Copenhagen, Denmark
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- Margeli Vila, Mireia (author)
- Hosp Badalona Germans Trias and Pujol, Badalona, Spain
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- Jakesz, Raimund (author)
- Univ Vienna, Gen Hosp, Vienna, Austria
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- Demol, Jan (author)
- Heilig Hart Ziekenhuis, Roeselare, Belgium
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- Dewar, Joanna (author)
- Sir Charles Gairdner Hosp, Nedlands, WA 6009, Australia
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- Santoro, Armando (author)
- Ist Clin Humanitas, Rozzano, Italy
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- Lluch, Ana (author)
- Hosp Clin Univ, Valencia, Spain
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- Olsen, Steven (author)
- Sanofi Aventis, Paris, France
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- Gelber, Richard D (author)
- Dana Farber Canc Inst, Dept Biostat and Computat Biol, Boston, MA 02115 USA
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- Di Leo, Angelo (author)
- Hosp Prato, Sandro Pitigliani Med Oncol Unit, Prato, Italy
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- Piccart-Gebhart, Martine (author)
- Inst Jules Bordet, B-1000 Brussels, Belgium
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(creator_code:org_t)
- 2009-09-03
- 2010
- English.
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In: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 119:1, s. 145-153
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Obesity has been shown to be an indicator of poor prognosis for patients with primary breast cancer (BC) regardless of the use of adjuvant systemic therapy. Patients and methods: This is a retrospective analysis of 2,887 node-positive BC patients enrolled in the BIG 02-98 adjuvant study, a randomised phase III trial whose primary objective was to evaluate disease-free survival (DFS) by adding docetaxel to doxorubicin-based chemotherapy. In the current analysis, the effect of body mass index (BMI) on DFS and overall survival (OS) was assessed. BMI was obtained before the first cycle of chemotherapy. Obesity was defined as a BMI a parts per thousand yen 30 kg/mA(2). Results: In total, 547 (19%) patients were obese at baseline, while 2,340 (81%) patients were non-obese. Estimated 5-year OS was 87.5% for non-obese and 82.9% for obese patients (HR 1.34; P = 0.013). Estimated 5-years DFS was 75.9% for non-obese and 70.0% for obese patients (HR 1.20; P = 0.041). In a multivariate model, obesity remained an independent prognostic factor for OS and DFS. Conclusions: In this study, obesity was associated with poorer outcome in node-positive BC patients. Given the increasing prevalence of obesity worldwide, more research on improving the treatment of obese BC patients is needed.
Keyword
- Breast cancer; Obesity; BMI; Adjuvant chemotherapy; Docetaxel; Node-positive
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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de Azambuja, Eva ...
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McCaskill-Steven ...
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Francis, Prudenc ...
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Quinaux, Emmanue ...
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Crown, John P A
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Vicente, Malou
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Giuliani, Rosa
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Nordenskjöld, Bo
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Gutierez, Jorge
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Andersson, Micha ...
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Margeli Vila, Mi ...
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Jakesz, Raimund
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Demol, Jan
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Dewar, Joanna
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Santoro, Armando
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Lluch, Ana
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Olsen, Steven
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Gelber, Richard ...
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Di Leo, Angelo
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Piccart-Gebhart, ...
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Breast Cancer Re ...
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Linköping University