SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Vinggaard Anne Marie) ;conttype:(refereed)"

Sökning: WFRF:(Vinggaard Anne Marie) > Refereegranskat

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Laursen, Martin F., et al. (författare)
  • Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut
  • 2021
  • Ingår i: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 6, s. 1367-1382
  • Tidskriftsartikel (refereegranskat)abstract
    • Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life immune development, and the gut microbiota can impact host physiology in various ways, such as through the production of metabolites. However, few breastmilk-dependent microbial metabolites mediating host–microbiota interactions are currently known. Here, we demonstrate that breastmilk-promoted Bifidobacterium species convert aromatic amino acids (tryptophan, phenylalanine and tyrosine) into their respective aromatic lactic acids (indolelactic acid, phenyllactic acid and 4-hydroxyphenyllactic acid) via a previously unrecognized aromatic lactate dehydrogenase (ALDH). The ability of Bifidobacterium species to convert aromatic amino acids to their lactic acid derivatives was confirmed using monocolonized mice. Longitudinal profiling of the faecal microbiota composition and metabolome of Danish infants (n = 25), from birth until 6 months of age, showed that faecal concentrations of aromatic lactic acids are correlated positively with the abundance of human milk oligosaccharide-degrading Bifidobacterium species containing the ALDH, including Bifidobacterium longum, B. breve and B. bifidum. We further demonstrate that faecal concentrations of Bifidobacterium-derived indolelactic acid are associated with the capacity of these samples to activate in vitro the aryl hydrocarbon receptor (AhR), a receptor important for controlling intestinal homoeostasis and immune responses. Finally, we show that indolelactic acid modulates ex vivo immune responses of human CD4+ T cells and monocytes in a dose-dependent manner by acting as an agonist of both the AhR and hydroxycarboxylic acid receptor 3 (HCA3). Our findings reveal that breastmilk-promoted Bifidobacterium species produce aromatic lactic acids in the gut of infants and suggest that these microbial metabolites may impact immune function in early life.
  •  
2.
  • Bergman, Åke, et al. (författare)
  • Science and policy on endocrine disrupters must not be mixed : a reply to a "common sense" intervention by toxicology journal editors
  • 2013
  • Ingår i: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 12
  • Tidskriftsartikel (refereegranskat)abstract
    • The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat  (2)Ta bort avgränsningen
Författare/redaktör
Vinggaard, Anne Mari ... (2)
Brandt, Ingvar (1)
Agace, William (1)
Michaelsen, Kim F (1)
Giudice, Linda C. (1)
Mörbe, Urs (1)
visa fler...
Wiberg, Karin (1)
Andersson, Anna-Mari ... (1)
Skakkebaek, Niels E. (1)
Juul, Anders (1)
Bergman, Åke (1)
Toppari, Jorma (1)
Bornehag, Carl-Gusta ... (1)
Zoeller, R. Thomas, ... (1)
Lind, Monica (1)
Norrgren, Leif (1)
van den Berg, Martin (1)
Scheringer, Martin (1)
Martin, Olwenn V. (1)
Frandsen, Henrik L. (1)
Muir, Derek (1)
Söder, Olle (1)
Rudén, Christina (1)
Becher, Georg (1)
Blumberg, Bruce (1)
Bjerregaard, Poul (1)
Bornman, Riana (1)
Casey, Stephanie C. (1)
Frouin, Heloise (1)
Iguchi, Taisen (1)
Jobling, Susan (1)
Kidd, Karen A. (1)
Kortenkamp, Andreas (1)
Ochieng, Roseline (1)
Ropstad, Erik (1)
Ross, Peter S. (1)
Vandenberg, Laura N. (1)
Brian, Jayne V. (1)
Fowler, Paul A. (1)
Hass, Ulla (1)
Olea, Nicolas (1)
Sonnenschein, Carlos (1)
Soto, Ana (1)
Swan, Shanna (1)
Tyler, Charles R. (1)
Dragsted, Lars O (1)
Brix, Susanne (1)
Roager, Henrik M. (1)
Bahl, Martin I. (1)
Moll, Janne Marie (1)
visa färre...
Lärosäte
Uppsala universitet (1)
Örebro universitet (1)
Lunds universitet (1)
RISE (1)
Karlstads universitet (1)
Karolinska Institutet (1)
visa fler...
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
Naturvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy