| 1. |
- Blösch, Günter, et al.
(författare)
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Twenty-three unsolved problems in hydrology (UPH) - a community perspective
- 2019
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Ingår i: Hydrological Sciences Journal. - : Informa UK Limited. - 0262-6667 .- 2150-3435. ; 64:10, s. 1141-1158
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Tidskriftsartikel (refereegranskat)abstract
- This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through online media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the diversity of the participants (230 scientists in total), the process revealed much about community priorities and the state of our science: a preference for continuity in research questions rather than radical departures or redirections from past and current work. Questions remain focused on the process-based understanding of hydrological variability and causality at all space and time scales. Increased attention to environmental change drives a new emphasis on understanding how change propagates across interfaces within the hydrological system and across disciplinary boundaries. In particular, the expansion of the human footprint raises a new set of questions related to human interactions with nature and water cycle feedbacks in the context of complex water management problems. We hope that this reflection and synthesis of the 23 unsolved problems in hydrology will help guide research efforts for some years to come.
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| 2. |
- Bauer, Juergen, et al.
(författare)
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Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People : A Position Paper From the PROT-AGE Study Group
- 2013
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Ingår i: Journal of the American Medical Directors Association. - : Elsevier BV. - 1525-8610 .- 1538-9375. ; 14:8, s. 542-559
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Tidskriftsartikel (refereegranskat)abstract
- New evidence shows that older adults need more dietary protein than do younger adults to support good health, promote recovery from illness, and maintain functionality. Older people need to make up for age-related changes in protein metabolism, such as high splanchnic extraction and declining anabolic responses to ingested protein. They also need more protein to offset inflammatory and catabolic conditions associated with chronic and acute diseases that occur commonly with aging. With the goal of developing updated, evidence-based recommendations for optimal protein intake by older people, the European Union Geriatric Medicine Society (EUGMS), in cooperation with other scientific organizations, appointed an international study group to review dietary protein needs with aging (PROT-AGE Study Group). To help older people (>65 years) maintain and regain lean body mass and function, the PROT-AGE study group recommends average daily intake at least in the range of 1.0 to 1.2 g protein per kilogram of body weight per day. Both endurance-and resistance-type exercises are recommended at individualized levels that are safe and tolerated, and higher protein intake (ie, >= 1.2 g/kg body weight/d) is advised for those who are exercising and otherwise active. Most older adults who have acute or chronic diseases need even more dietary protein (ie, 1.2-1.5 g/kg body weight/d). Older people with severe kidney disease (ie, estimated GFR <30 mL/min/1.73m(2)), but who are not on dialysis, are an exception to this rule; these individuals may need to limit protein intake. Protein quality, timing of ingestion, and intake of other nutritional supplements may be relevant, but evidence is not yet sufficient to support specific recommendations. Older people are vulnerable to losses in physical function capacity, and such losses predict loss of independence, falls, and even mortality. Thus, future studies aimed at pinpointing optimal protein intake in specific populations of older people need to include measures of physical function.
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| 3. |
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| 4. |
- Heindel, Jerrold J., et al.
(författare)
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Parma consensus statement on metabolic disruptors
- 2015
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Ingår i: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as "metabolic disruptors", in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.
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| 5. |
- Maggio, Marcello, et al.
(författare)
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Vitamin D and Endothelial Vasodilation in Older Individuals : Data From the PIVUS Study
- 2014
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 99:9, s. 3382-3389
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT:Vitamin D plays a role in a wide range of extraskeletal processes, including vascular function. Endothelial dysfunction is a predictor of cardiovascular disease, especially in older subjects. However, the relationship between vitamin D levels and indexes of endothelial vasodilation has never been fully addressed in older individuals.OBJECTIVE:The objective of this study was to examine the association between vitamin D and endothelial function in a large community-based sample of older subjects.METHODS:This cross-sectional study involved 852 community-dwelling men and women aged 70 years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), with complete data on vascular function and 25-hydroxyvitamin D. We evaluated endothelium-dependent vasodilation by an invasive forearm technique with acetylcholine, endothelium-independent vasodilation by sodium nitroprussiate, flow-mediated vasodilation, and the pulse wave analysis (reflectance index). Vitamin D levels were measured by chemiluminescence. We used multivariate regression models adjusted for body mass index (model 1) and for multiple confounders (high-sensitivity C-reactive protein, insulin, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, smoking, sex hormones, season of blood collection, hypertension, diabetes, cardiovascular medications and diseases, statin usage, plasma calcium and calcium intake, PTH, physical exercise, liver and kidney function tests, albumin; model 2).RESULTS:In women, but not in men, vitamin D levels were positively associated with endothelium-independent vasodilation in both model 1 (β ± SE = 1.41 ± 0.54; P = .001), and model 2 (β ± SE = 2.01 ± 0.68; P = .003).We found no significant relationship between vitamin D levels and endothelium-dependent vasodilation, flow-mediated vasodilation, and reflectance index in both sexes.CONCLUSIONS:In older women, but not in men, vitamin D is positively and independently associated with EIDV.
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| 6. |
- Okoli, Kenechukwu, et al.
(författare)
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Model averaging versus model selection : estimating design floods with uncertain river flow data
- 2018
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Ingår i: Hydrological Sciences Journal. - : Taylor & Francis. - 0262-6667 .- 2150-3435. ; 63:13-14, s. 1913-1926
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Tidskriftsartikel (refereegranskat)abstract
- This study compares model averaging and model selection methods to estimate design floods, while accounting for the observation error that is typically associated with annual maximum flow data. Model selection refers to methods where a single distribution function is chosen based on prior knowledge or by means of selection criteria. Model averaging refers to methods where the results of multiple distribution functions are combined. Numerical experiments were carried out by generating synthetic data using the Wakeby distribution function as the parent distribution. For this study, comparisons were made in terms of relative error and root mean square error (RMSE) referring to the 1-in-100 year flood. The experiments show that model averaging and model selection methods lead to similar results, especially when short samples are drawn from a highly asymmetric parent. Also, taking an arithmetic average of all design flood estimates gives estimated variances similar to those obtained with more complex weighted model averaging.
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| 7. |
- Papacharalampous, Georgia, et al.
(författare)
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Global-scale massive feature extraction from monthly hydroclimatic time series : Statistical characterizations, spatial patterns and hydrological similarity
- 2021
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 767
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Tidskriftsartikel (refereegranskat)abstract
- Hydroclimatic time series analysis focuses on a few feature types (e.g., autocorrelations, trends, extremes), which describe a small portion of the entire information content of the observations. Aiming to exploit a larger part of the available information and, thus, to deliver more reliable results (e.g., in hydroclimatic time series dustering contexts), here we approach hydroclimatic time series analysis differently, i.e., by performing massive feature extraction. In this respect, we develop a big data framework for hydroclimatic variable behaviour characterization. This framework relies on approximately 60 diverse features and is completely automatic (in the sense that it does not depend on the hydroclimatic process at hand). We apply the new framework to characterize mean monthly temperature, total monthly precipitation and mean monthly river flow. The applications are conducted at the global scale by exploiting 40-year-long time series originating from over 13 000 stations. We extract interpretable knowledge on seasonality, trends, autocorrelation, long-range dependence and entropy, and on feature types that are met less frequently. We further compare the examined hydroclimatic variable types in terms of this knowledge and, identify patterns related to the spatial variability of the features. For this latter purpose, we also propose and exploit a hydroclimatic time series dustering methodology. This new methodology is based on Breiman's random forests. The descriptive and exploratory insights gained by the global-scale applications prove the usefulness of the adopted feature compilation in hydroclimatic contexts. Moreover, the spatially coherent patterns characterizing the clusters delivered by the new methodology build confidence in its future exploitation. Given this spatial coherence and the scale-independent nature of the delivered feature values (which makes them particularly useful in forecasting and simulation contexts), we believe that this methodology could also be beneficial within regionalization frameworks. in which knowledge on hydrological similarity is exploited in technical and operative terms.
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