| 1. |
- Bergwall, Peter, et al.
(författare)
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Law, Materiality & Justice
- 2016
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Ingår i: Scandinavian Studies in Law : Law without the state - Law without the state. - 9789185142767 ; 62, s. 35-60
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Can law still play a central role in governing human behavior even if the state law may have become less important? Whether law without the state is possible depends, of course, on how we define “law” and “state”. But it also depends on the perspective from which one approaches the legal material. From a sociology of law perspective, as will be presented in this chapter, the topic has a slightly different signification and consequence than within traditional legal dogmatics. After all, going back to the pioneers of sociological jurisprudence and sociology of law as, for example, Roscoe Pound (1870-1964) and Eugene Ehrlich (1862-1922), we hear the echoes of a time when the state had not yet grown so strong (Berman 1983). Surely, the times of Pound and Ehrlich were characterized less by “state-law” compared to present times. Still, would we describe the early 20th Century as governed by “non-state law”?In the first section, Materialism Revisited, we briefly show how materialism with roots in Marxian and Althusserian thought is making its way back into social theory. The implication is a challenge of importunate dichotomies, such as the social subject/object and the legal ought/is. In the next section, we proceed with the theoretical developments, labelled new materialism, emphasizing the flows generated by social and legal structures, rather than the structures per se. We then proceed to one of the main objectives of this chapter, the discussion building on the argument that materialist conceptions are essential in empirically grounded justice theories. Hence, the Justice section includes a brief overview of classical justice theories, followed by the critique of them, and a proposition that materialistic, evidencebased procedural justice theories are better equipped for socio-legal research compared to more idealistically grounded justice theories. We then present a research project which is about how distributive and procedural justice affects the intention to disclose personal health information in online contexts. We conclude by stating that, what we label emergent social order, i.e., the interplay between law, materiality and social normativity, is important for understanding the current condition, which is characterized by some as governed by “non-state law”.
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| 2. |
- Ederle, Joerg, et al.
(författare)
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Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
- 2010
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Ingår i: The Lancet. - 1474-547X. ; 375:9719, s. 985-997
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Tidskriftsartikel (refereegranskat)abstract
- Background Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Findings The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4.0%) events of disabling stroke or death in the stenting group compared with 27 (3.2%) events in the endarterectomy group (hazard ratio [HR] 1.28, 95% CI 0.77-2.11). The incidence of stroke, death, or procedural myocardial infarction was 8.5% in the stenting group compared with 5.2% in the endarterectomy group (72 vs 44 events; HR 1.69, 1.16-2.45, p=0.006), Risks of any stroke (65 vs 35 events; HR 1.92, 1.27-2.89) and all-cause death (19 vs seven events; HR 2.76, 1.16-6.56) were higher in the stenting group than in the endarterectomy group. Three procedural myocardial infarctions were recorded in the stenting group, all of which were fatal, compared with four, all non-fatal, in the endarterectomy group. There was one event of cranial nerve palsy in the stenting group compared with 45 in the endarterectomy group. There were also fewer haematomas of any severity in the stenting group than in the endarterectomy group (31 vs 50 events; p=0.0197). Interpretation Completion of long-term follow-up is needed to establish the efficacy of carotid artery stenting compared with endarterectomy. In the meantime, carotid endarterectomy should remain the treatment of choice for patients suitable for surgery.
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| 3. |
- Johansson, Christer, et al.
(författare)
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Impacts of air pollution and health by changing commuting from car to bicycle
- 2017
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 584-585, s. 55-63
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Tidskriftsartikel (refereegranskat)abstract
- Our study is based on individual data on people’s home and work addresses, as well as their age, sex and physical capacity, in order to establish realistic bicycle-travel distances. A transport model is used to single out data on commuting preferences in the County Stockholm. Our analysis shows there is a very large potential for reducing emissions and exposure if all car drivers living within a distance corresponding to a maximum of a 30 minute bicycle ride to work would change to commuting by bicycle. It would result in more than 111 000 new cyclists, corresponding to an increase of 209% compared to the current situation.Mean population exposure would be reduced by about 7% for both NOx and black carbon (BC) in the most densely populated area of the inner city of Stockholm. Applying a relative risk for NOx of 8% decrease in all-cause mortality associated with a 10 µg m-3 decrease in NOx, this corresponds to more than 449 (95% CI: 340 - 558) years of life saved annually for the Stockholm county area with 2.1 million inhabitants. This is more than double the effect of the reduced mortality estimated for the introduction of congestion charge in Stockholm in 2006. Using NO2 or BC as indicator of health impacts, we obtain 395 (95% CI: 172 - 617) and 185 (95% CI: 158 - 209) years of life saved for the population, respectively. The calculated exposure of BC and its corresponding impacts on mortality are likely underestimated. With this in mind the estimates using NOx, NO2 and BC show quite similar health impacts considering the 95% confidence intervals.
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| 4. |
- Lövenheim, Boel, et al.
(författare)
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Health risk assessment of reduced air pollution exposure when changing commuting by car to bike
- 2016
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Konferensbidrag (refereegranskat)abstract
- In this study we have assessed the reduction in traffic emissions and population exposure assuming all potential car commuters would switch to biking if they live within 30 minute travel by bike. The scenario would result in more than 100 000 new bikers and due to the reduced traffic emissions 42 premature deaths would be avoided per year. This is almost twice as large effect as the congestion tax in Stockholm. Introduction Regular physical activity has important and wide-ranging health benefits including reduced risk of chronic disease, and physical inactivity is mentioned as perhaps the most important public health problem of the 21st century. At the same time, the direct effects of traffic emissions is a major health problem. Transferring commuting by car to bike will increase physical activity and reduce emissions and reduce population exposure to traffic pollution. The exposure of commuters will also change; new bikers may get higher exposure whilst old bikers and car drivers may get lower exposures, depending on commuting route and distance. Methodology In this study we have calculated the potential number of car-to-bike switching commuters depending on distance, travel time, age of commuters, etc. We have made calculations for a 30-minute biking scenario, i.e. transferring all car commuters to bike if their travel time by bike is less than or equal to 30 minutes. The commuting distance depends on age and sex. For the travel and traffic modelling the LuTrans model was used. It includes all different modes of travel; walking, bicycling, public transport systems and car traffic. The model was developed based on travel survey data and is regularly calibrated using traffic counts. Emissions from road traffic were calculated based on HBEFA 3.2. A Gaussian dispersion model was used estimate exposures over the county of Stockholm. Results The 30 min scenario resulted in 106 881 more bikers, an increase of 2.6 times compared to base scenario. Of all bikers 50% were men and the mean age of all bikers was 42. The traffic emissions of NOx was reduced by up to 7%. Up to 20% reduction in traffic contribution to NOx concentrations was calculated as shown in Figure 1. The mean reduction in concentration for the whole area is 6% and the largest occur were most people live.The population weighted mean NOx concentration for 1.6 million people in Greater Stockholm is estimated to be reduced by 0.41 μg m-3. Assuming that the premature mortality is reduced by 8% per 10 μg m-3 (Nafstad et al., 2004), this corresponds to 42 avoided premature deaths every year or 514 gained life years gained. This is even somewhat more beneficial than the effects of the congestion charge in Stockholm (Johansson et al., 2009), which was estimated to save 27 premature deaths per year. The gain in reduced mortality is almost as large as the gain in health of the increased physical activity. Conclusions Transferring car commuters to bike is not only beneficial for the physical activity, but will also lead to reduced traffic emissions and reduced population exposure. Our estimates show that it may be even more beneficial for mortality due to air pollution exposure than the congestion charge in Stockholm. Acknowledgement This project was funded by the Swedish Research Council for Health, Working life and Welfare. References Johansson, C., Burman, L., Forsberg, B. 2009. The effects of congestions tax on air quality and health. Atmos. Environ. 43, 4843-4854.Nafstad, P., Lund Håheim, L., Wisloeff, T., Gram, G., Oftedal, B., Holme, I., Hjermann, I. and Leren, P. 2004. Urban Air Pollution and Mortality in a Cohort of Norwegian Men. Environ. Health Perspect. 112, 610-615.
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| 5. |
- Nordanstig, Joakim, et al.
(författare)
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Mortality with Paclitaxel-Coated Devices in Peripheral Artery Disease.
- 2020
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Ingår i: The New England journal of medicine. - : Massachusetts Medical Society. - 1533-4406 .- 0028-4793. ; 383, s. 2538-46
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Tidskriftsartikel (refereegranskat)abstract
- The results of a recent meta-analysis aroused concern about an increased risk of death associated with the use of paclitaxel-coated angioplasty balloons and stents in lower-limb endovascular interventions for symptomatic peripheral artery disease.We conducted an unplanned interim analysis of data from a multicenter, randomized, open-label, registry-based clinical trial. At the time of the analysis, 2289 patients had been randomly assigned to treatment with drug-coated devices (the drug-coated-device group, 1149 patients) or treatment with uncoated devices (the uncoated-device group, 1140 patients). Randomization was stratified according to disease severity on the basis of whether patients had chronic limb-threatening ischemia (1480 patients) or intermittent claudication (809 patients). The single end point for this interim analysis was all-cause mortality.No patients were lost to follow-up. Paclitaxel was used as the coating agent for all the drug-coated devices. During a mean follow-up of 2.49 years, 574 patients died, including 293 patients (25.5%) in the drug-coated-device group and 281 patients (24.6%) in the uncoated-device group (hazard ratio, 1.06; 95% confidence interval, 0.92 to 1.22). At 1 year, all-cause mortality was 10.2% (117 patients) in the drug-coated-device group and 9.9% (113 patients) in the uncoated-device group. During the entire follow-up period, there was no significant difference in the incidence of death between the treatment groups among patients with chronic limb-threatening ischemia (33.4% [249 patients] in the drug-coated-device group and 33.1% [243 patients] in the uncoated-device group) or among those with intermittent claudication (10.9% [44 patients] and 9.4% [38 patients], respectively).In this randomized trial in which patients with peripheral artery disease received treatment with paclitaxel-coated or uncoated endovascular devices, the results of an unplanned interim analysis of all-cause mortality did not show a difference between the groups in the incidence of death during 1 to 4 years of follow-up. (Funded by the Swedish Research Council and others; ClinicalTrials.gov number, NCT02051088.).
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| 6. |
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50 Years of Law and IT : The Swedish Law and Informatics Research Institute 1968-2018
- 2018
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- In 1968, the first seminar on Electronic Data Processing and Law was held at Stockholm University. Later that year The Working Party for EDP and Law was established. The topic soon became part of the legal curricula and a meeting point for scholars and professionals with background in information science and law.
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| 7. |
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A Proactive Approach : Law Libraries
- 2006
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Reliance on routines to avoid mistakes is a self-evident feature of many fields of human activity. The commercial pilot preparing for take-off, the engineer designing a bridge and the insurance company introducing a new product all depend on proven methods to ensure that nothing important is forgotten and to assess the consequences of planned measures. Legal work is somewhat atypical in the foregoing respect. Compared with many other activities, there are few descriptions of how the various segments of a legal task are to be devised in order to achieve the greatest possible certainty of result. Lawyers tend to work reactively, i.e., the focus is on solving problems that have already arisen. Efforts aimed at avoiding problems before they begin to brew - i.e., proactively - are less common. The proactive approach is not unknown in the legal sphere but as compared to many other fields of the law the perspective is not very well elaborated. Against this background this volume of Scandinavian Studies in Law presents 25 articles on various aspects of proactive approaches in law, the majority of them focusing on contracting issues. The collection is simultaneously a documentation of a conference on proactive law held in Stockholm 2005. In addition to the articles on proactive law this volume contains a presentation of major law libraries in the Scandinavian countries. Table of Contents: Barton, Thomas D., Thinking Preventively and Proactively, p. 71-92 Bing, Jon and Mahler, Tobias, Contractual Risk Management in an ICT Context - Searching for a Possible Interface between Legal Methods and Risk Analysis, p. 339-358 Cummins, Tim, Best Practices In Commercial Contracting, p. 131-148 Daicoff, Susan, The Comprehensive Law Movement: An Emerging Approach to Legal Problems, p. 109-128 Dauer, Eduard A., The Role of Culture in Legal Risk Management, p. 93-108 Haapio, Helena, Introduction to Proactive Law from a Business Lawyer's Point of View, p. 21-34 Haapio, Helena, Business Success and Problem Prevention through Proactive Contracting, p. 149-194 Haarala-Nystén, Soili, Contract Law and Everyday Contracting, p. 263-284 Haavisto, Vaula, Contracting in Networks, p. 237-254 Jakobsen Sandfeld, Søren, Entering New and Converging Media Markets: How to Take a Proactive Approach to Legal Issues in the Electronic Communications Sector, p. 393-406 Kavaleff, Anette, Successful Outsourcing through Proactive Contracting - Strategy, Risk Assessment and Implementation, p. 215-226 Lando, Henrik, Determinants of the Optimal Degree of Pro-activeness in Contracting, p. 255-262 Magnusson, Jarl S., Proactive Law - and the Importance of Data and Information Resources, p. 407-424 Magnusson Sjöberg, Cecilia, Presentation of the Nordic School of Proactive Law, p. 13-20 Paris, Carolyn E.C., Contract Management: Design Parameters and Challenges to Implementation, p. 195-214 Pohjonen, Soile, Proactive Law in Academia, p. 53-70 Sadighi Firozabadi, Babak and Sergot, Marek , The Role of Agreements in Virtual Organisations, p. 297-304 Schartum, Dag Wiese, Introduction to a Government-based Perspective on Proactive Law, p. 35-52 Seipel, Peter, Nordic School of Proactive Law Conference 2005: Closing Comments, p. 359-364 Syse, Aslak, Equality and Accessibility: A Proactive Approach to Strengthen the Legal Status and Protection Against Discrimination of Persons with Disabilities, p. 367-384 Taskinen, Tommi K.J., Some Thoughts on Proactive Counselling and Legal Mentality, p. 227-236 Trzaskowski, Jan, Legal Risk Management in a Global, Electronic Marketplace, p. 319-338 Weitzenböck, Emily M., Prevention is Better than Cure: Fostering the Growth of Dynamic Networked Organisations through the use of Proactive Legal Measures, p. 305-318 Vikström, Mats, The Impact of IT on the Foundation for Businesses Daily Operation, p. 285-296 Zimmer, Frederik, Tax Legislation between Politics and Legal (and Economic) Thinking, p. 385-392 Law Libraries in Denmark, p. 427-433 Law Libraries in Finland, p. 434-441 Norwegian Law Libraries, p. 442-447 Law Libraries in Sweden, p. 448-462
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| 8. |
- Ali, Abdullah, 1985-, et al.
(författare)
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Dehydration affects drug transport over nasal mucosa
- 2019
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Ingår i: Drug Delivery. - : Taylor & Francis. - 1071-7544 .- 1521-0464. ; 26:1, s. 831-840
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Tidskriftsartikel (refereegranskat)abstract
- Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that mucoadhesion achieved through water sorption could also be a constraint for drug absorption via the nasal route. The effect of altering water activity of the vehicle on Xylometazoline HCl and Cr-EDTA uptake was studied separately using flow through diffusion cells and excised porcine mucosa. We have shown that a modest increase in the water gradient over mucosa induces a substantial decrease in drug uptake for both Xylometazoline HCl and Cr-EDTA. A similar result was obtained when comparing two different vehicles on the market; Nasoferm (Nordic Drugs, Sweden) and BLOX4 (Bioglan, Sweden). Mucoadhesion based on water sorption can slow down drug uptake in the nasal cavity. However, a clinical study is required to determine whether prolonged duration of the vehicle or preventing dehydration of the mucosa is the most important factor for improving bioavailability.
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| 9. |
- Ali, Abdullah, 1985-, et al.
(författare)
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Tactile friction of topical creams and emulsions : Friction measurements on excised skin and VitroSkin® using ForceBoard™
- 2022
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Ingår i: International Journal of Pharmaceutics. - : Elsevier B.V.. - 0378-5173 .- 1873-3476. ; 615
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Tidskriftsartikel (refereegranskat)abstract
- Tactile perception can be investigated through ex vivo friction measurements using a so–called ForceBoard™, providing objective assessments and savings in time and money, compared to a subjective human panel. In this work we aim to compare excised skin versus VitroSkin® as model substrates for tactile friction measurements. A further aim is to detect possible differences between traditional surfactant-based creams, and a particle-stabilized (Pickering) cream and investigate how the different substrates affect the results obtained. It was found that the difference in tactile friction between excised skin and VitroSkin® was small on untreated substrates. When topical creams were applied, the same trends were observed for both substrates, although the frictional variation over time relates to the difference in surface structure between the two substrates. The results also confirmed that there is a difference between starch-based Pickering formulations and surfactant-based creams after application, indicating that the latter is greasier than Pickering cream. It was also shown that the tactile friction of Pickering emulsions was consistently high even with high amounts of oil, indicating a non-greasy, and non-sticky formulation. The characteristics of starch-stabilized Pickering formulations make them promising candidates in the development of surfactant-free topical formulations with unique tactile properties. © 2022 The Authors
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| 10. |
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