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Sökning: WFRF:(Waldsich Christina)

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1.
  • Cruz, Jose Almeida, et al. (författare)
  • RNA-Puzzles : A CASP-like evaluation of RNA three-dimensional structure prediction
  • 2012
  • Ingår i: RNA. - : Cold Spring Harbor Laboratory. - 1355-8382 .- 1469-9001. ; 18:4, s. 610-625
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises.
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2.
  • Flores, Samuel, et al. (författare)
  • Insights into diseases of human telomerase from dynamical modeling
  • 2013
  • Konferensbidrag (refereegranskat)abstract
    • Mutations in the telomerase complex disrupt either nucleic acid binding or catalysis, and are the cause of numerous human diseases. Despite its importance, the structure of the human telomerase complex has not been observed crystallographically, nor are its dynamics understood in detail. Fragments of this complex from Tetrahymena thermophila and Tribolium castaneum have been crystallized. Biochemical probes provide important insight into dynamics. In this work we summarize evidence that the T. castaneum structure is Telomerase Reverse Transcriptase. We use this structure to build a partial model of the human Telomerase complex. The model suggests an explanation for the structural role of several disease-associated mutations. We then generate a 3D kinematic trajectory of telomere elongation to illustrate a "typewriter" mechanism: the RNA template moves to keep the end of the growing telomeric primer in the active site, disengaging after every 6-residue extension to execute a "carriage return" and go back to its starting position. A hairpin can easily form in the primer, from DNA residues leaving the primer-template duplex. The trajectory is consistent with available experimental evidence. The methodology is extensible to many problems in structural biology in general and personalized medicine in particular.
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