SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wallaschofski H) ;lar1:(umu)"

Sökning: WFRF:(Wallaschofski H) > Umeå universitet

  • Resultat 1-4 av 4
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Locke, Adam E, et al. (författare)
  • Genetic studies of body mass index yield new insights for obesity biology.
  • 2015
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
  •  
3.
  • Berndt, Sonja I., et al. (författare)
  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
  • 2013
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
  • Tidskriftsartikel (refereegranskat)abstract
    • Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
  •  
4.
  • Lu, Yingchang, et al. (författare)
  • New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
  • 2016
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-4 av 4
Typ av publikation
tidskriftsartikel (4)
Typ av innehåll
refereegranskat (4)
Författare/redaktör
Vandenput, Liesbeth, ... (4)
Lind, Lars (4)
Ohlsson, Claes, 1965 (4)
Gustafsson, Stefan (4)
Groop, Leif (3)
Salomaa, Veikko (3)
visa fler...
Perola, Markus (3)
Campbell, Harry (3)
Rudan, Igor (3)
Deloukas, Panos (3)
Shungin, Dmitry (3)
North, Kari E. (3)
Wareham, Nicholas J. (3)
Johansson, Åsa (3)
Stancáková, Alena (3)
Kuusisto, Johanna (3)
Laakso, Markku (3)
McCarthy, Mark I (3)
van Duijn, Cornelia ... (3)
Langenberg, Claudia (3)
Boehnke, Michael (3)
Mohlke, Karen L (3)
Ingelsson, Erik (3)
Mangino, Massimo (3)
Oostra, Ben A. (3)
Gieger, Christian (3)
Peters, Annette (3)
Gyllensten, Ulf (3)
Froguel, Philippe (3)
Luan, Jian'an (3)
Wright, Alan F. (3)
Wilson, James F. (3)
Karpe, Fredrik (3)
Eriksson, Johan G. (3)
Zillikens, M. Carola (3)
Rivadeneira, Fernand ... (3)
Harris, Tamara B (3)
Loos, Ruth J F (3)
Hofman, Albert (3)
Uitterlinden, André ... (3)
Hayward, Caroline (3)
Gudnason, Vilmundur (3)
Hirschhorn, Joel N. (3)
McKnight, Barbara (3)
Cupples, L. Adrienne (3)
Kivimaki, Mika (3)
Kumari, Meena (3)
van der Harst, Pim (3)
Kanoni, Stavroula (3)
Prokopenko, Inga (3)
visa färre...
Lärosäte
Göteborgs universitet (4)
Umeå universitet  (4)Ta bort avgränsningen
Uppsala universitet (4)
Lunds universitet (4)
Karolinska Institutet (4)
Högskolan Dalarna (1)
Språk
Engelska (4)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (4)
Naturvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy