| 1. |
- Vos, Theo, et al.
(författare)
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Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- 2015
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
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Tidskriftsartikel (refereegranskat)abstract
- Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
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| 2. |
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| 3. |
- Basmarke-Wehelie, Rahma, et al.
(författare)
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The complement regulator CD46 is bactericidal to Helicobacter pylori and blocks urease activity
- 2011
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Ingår i: Gastroenterology. - Baltimore : Elsevier BV. - 0016-5085 .- 1528-0012. ; 141:3, s. 918-928
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: CD46 is a C3b/C4b binding complement regulator and a receptor for several human pathogens. We examined the interaction between CD46 and Helicobacter pylori (a bacterium that colonizes the human gastric mucosa and causes gastritis), peptic ulcers, and cancer.METHODS: Using gastric epithelial cells, we analyzed a set of H pylori strains and mutants for their ability to interact with CD46 and/or influence CD46 expression. Bacterial interaction with full-length CD46 and small CD46 peptides was evaluated by flow cytometry, fluorescence microscopy, enzyme-linked immunosorbent assay, and bacterial survival analyses.RESULTS: H pylori infection caused shedding of CD46 into the extracellular environment. A soluble form of CD46 bound to H pylori and inhibited growth, in a dose- and time-dependent manner, by interacting with urease and alkyl hydroperoxide reductase, which are essential bacterial pathogenicity-associated factors. Binding of CD46 or CD46-derived synthetic peptides blocked the urease activity and ability of bacteria to survive in acidic environments. Oral administration of one CD46 peptide eradicated H pylori from infected mice.CONCLUSIONS: CD46 is an antimicrobial agent that can eradicate H pylori. CD46 peptides might be developed to treat H pylori infection.
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| 4. |
- Bergman, Brita, 1946-, et al.
(författare)
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Noun and Verbal Classifiers in Swedish Sign Language
- 2003
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Ingår i: Perspectives on Classifier Constructions in Sign Language. - Mahwah, N.J. : Lawrence Erlbaum Associates. - 0805842691 ; , s. 35-51
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Bokkapitel (refereegranskat)
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| 5. |
- Björkstrand, Thomas, et al.
(författare)
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Svenskt teckenspråkslexikon
- 2010
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Annan publikation (mjukvara/multimedium) (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Börstell, Carl, et al.
(författare)
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Segmenting the Swedish Sign Language corpus : On the possibilities of using visual cues as a basis for syntactic segmentation
- 2014
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Ingår i: Workshop Proceedings. - Paris : ELRA. ; , s. 7-10
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Konferensbidrag (refereegranskat)abstract
- This paper deals with the possibility of conducting syntactic segmentation of the Swedish Sign Language Corpus (SSLC) on the basisof the visual cues from both manual and nonmanual signals. The SSLC currently features segmentation on the lexical level only, whichis why the need for a linguistically valid segmentation on e.g. the clausal level would be very useful for corpus-based studies on thegrammatical structure of Swedish Sign Language (SSL). An experiment was carried out letting seven Deaf signers of SSL each segmenttwo short texts (one narrative and one dialogue) using ELAN, based on the visual cues they perceived as boundaries. This was latercompared to the linguistic analysis done by a language expert (also a Deaf signer of SSL), who segmented the same texts into whatwas considered syntactic clausal units. Furthermore, these segmentation procedures were compared to the segmentation done for theSwedish translations also found in the SSLC. The results show that though the visual and syntactic segmentations overlap in manycases, especially when a number of cues coincide, the visual segmentation is not consistent enough to be used as a means of segmentingsyntactic units in the SSLC.
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| 7. |
- Hawkes, Jeffrey A., et al.
(författare)
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Regional diversity of complex dissolved organic matter across forested hemiboreal headwater streams
- 2018
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Dissolved organic matter (DOM) from soils enters the aquatic environment via headwater streams. Thereafter, it is gradually transformed, removed by sedimentation, and mineralised. Due to the proximity to the terrestrial source and short water residence time, the extent of transformation is minimal in headwaters. DOM has variable composition across inland waters, but the amount of variability in the terrestrial end member is unknown. This gap in knowledge is crucial considering the potential impact large variability would have on modelling DOM degradation. Here, we used a novel liquid chromatography –mass spectrometry method to characterise DOM in 74 randomly selected, forested headwater streams in an 87,000 km2 region of southeast Sweden. We found a large degree of sample similarity across this region, with Bray-Curtis dissimilarity values averaging 8.4 ± 3.0% (mean ± SD). The identified variability could be reduced to two principle coordinates, correlating to varying groundwater flow-paths and regional mean temperature. Our results indicate that despite reproducible effects of groundwater geochemistry and climate, the composition of DOM is remarkably similar across catchments already as it leaves the terrestrial environment, rather than becoming homogeneous as different headwaters and sub-catchments mix.
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| 8. |
- Keller, Lina, et al.
(författare)
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The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: clinical report and quantification of A beta in different brain regions
- 2010
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Ingår i: European Journal of Human Genetics. - London : Springer Science and Business Media LLC. - 1476-5438 .- 1018-4813. ; 18:11, s. 1202-1208
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Tidskriftsartikel (refereegranskat)abstract
- Early-onset dominantly inherited forms of Alzheimer's disease (AD) are rare, but studies of such cases have revealed important information about the disease mechanisms. Importantly, mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and PSEN2, alter the APP processing and lead to an increased amyloid beta-peptide (A beta) 42/40 ratio. This, together with other studies on pathogenic mechanisms, show that A beta 42 is a major player in the etiology of AD. Here, we present a clinical and neuropathological description of a Swedish family with an I143T mutation in the PSEN1 gene, which gives rise to a severe form of AD. We also performed an extensive investigation on the concentration and distribution of A beta species of different lengths in six brain regions from two mutation carriers. Our study showed that A beta 42 and a longer peptide, A beta 43, were present both in plaque cores and in total amyloid preparations, and were each clearly more frequent than A beta 40 in all examined regions, as shown by both mass spectrometry and immunohistochemistry. European Journal of Human Genetics (2010) 18, 1202-1208; doi: 10.1038/ejhg.2010.107; published online 14 July 2010
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| 9. |
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| 10. |
- Mesch, Johanna, 1963-, et al.
(författare)
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From meaning to signs and back : Lexicography and the Swedish Sign Language Corpus
- 2012
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Ingår i: 5thWorkshop on the Representation and Processing of Sign Languages: Interactions between Corpus and Lexicon. ; , s. 127-130
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Konferensbidrag (refereegranskat)abstract
- In this paper, we will present the advantages of having a reference dictionary, and how having a corpus makes dictionary making easier and more effective. It also gives a new perspective on sign entries in the dictionary, for example, if a sign uses one or two hands, or which meaning “genuine signs” have, and it helps find a model for categorization of polysynthetic signs that is not found in the dictionary. Categorizing glosses in the corpus work has compelled us to revisit the dictionary to add signs from the corpus that are not already in the dictionary and to improve sign entries already in the dictionary based on insights that have been gained while working on the corpus.
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