| 1. |
- Gusev, A, et al.
(författare)
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
- 2016
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 10979-
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Tidskriftsartikel (refereegranskat)abstract
- Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
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| 2. |
- Edner, H, et al.
(författare)
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Atmospheric Mercury Mapping In A Cinnabar Mining Area
- 1993
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Ingår i: Science of the Total Environment. - 1879-1026. ; 133:1-2, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- A mobile differential absorption lidar system was used in conjunction with point monitors to study the spatial and temporal distribution of atomic mercury in the atmosphere around an abandoned mercury mine at Abbadia S. Salvatore, Italy. The use of the remote sensing technique allows a fast coverage of large areas both horizontally and vertically with a good temporal resolution. Concentrations exceeding 1000 ng/m3 were measured close to the distillation plant and considerably elevated values also were evident above deposits of roasted cinnabar. Vertical gradients of the mercury concentration in air were established. These showed a very pronounced decrease a few centimeters above the ground.
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| 3. |
- Edner, H, et al.
(författare)
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Differential Absorption Lidar Mapping of Atmospheric Atomic Mercury In Italian Geothermal Fields
- 1992
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Ingår i: Journal of Geophysical Research. - 2156-2202. ; 97:D4, s. 3779-3786
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Tidskriftsartikel (refereegranskat)abstract
- Results from extensive lidar measurements on atmospheric atomic mercury in Italian geothermal fields are reported. A mobile differential absorption lidar system operating on the 254-nm mercury resonance line with a measuring range of about 1 km was used in mineralized as well as nonmineralized areas. Measurements were performed at geothermal power stations and in an unexploited field with natural surface geothermic manifestations. Atomic mercury concentrations ranging from 2 to 1000 ng/m3 were mapped. The high Italian geothermal mercury concentrations are in strong contrast to the recent lidar finding of the absence of atomic mercury in Icelandic geothermal fields.
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| 4. |
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| 5. |
- Edner, H, et al.
(författare)
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Fluorescence Lidar Multicolor Imaging of Vegetation
- 1994
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Ingår i: Optical Society of America. Journal B: Optical Physics. - 0740-3224. ; 33:13, s. 2471-2479
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Tidskriftsartikel (refereegranskat)abstract
- Multicolor imaging of vegetation fluorescence following laser excitation is reported for distances of 50 m. A mobile laser-radar system equipped with a Nd:YAG laser transmitter and a 40-cm-diameter telescope was utilized. The laser light was Raman shifted to 397 nm with pulse energies of approximately 30 mJ. An image-intensified CCD camera with a specially designed split-mirror Cassegrainian telescope was utilized for the simultaneous recording of fluorescence images of leaves and branches in four different spectral bands. Additionally, fluorescence spectra at selected points within the detection area were measured with an image-intensified diode array system. Image processing permits extraction of information related to the physiological status of the vegetation and might prove useful in forest decline research.
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| 6. |
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| 7. |
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| 9. |
- Ferrara, R, et al.
(författare)
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Atmospheric Mercury Emission At Solfatara Volcano (Pozzuoli, Phlegraean Fields, Italy)
- 1994
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Ingår i: Chemosphere. - : Elsevier BV. - 1879-1298 .- 0045-6535. ; 29:7, s. 1421-1428
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Tidskriftsartikel (refereegranskat)abstract
- Mercury concentrations in air and in condensed steam coming from fumarolic activity at the Solfatara crater (Phlegraean Fields - Italy) were determined. In the condensed steam, mercury was found mainly associated as Hg-S complexes and showed a flux in the range from 0.9 to 4.5 g day(-1). Using the point monitor technique, high values (up to 690 ng m(-3)) of atmospheric mercury levels were observed only close to the main exhaling areas, while background levels (2 ng m(-3)) were measured over the crater area using the lidar technique. An upper limit (<2.4 g day(-1)) for the flux of elemental mercury in air was estimated with the lidar. This remote sensing technique also allowed to assess an upper limit for the SO2 flux (<24 kg day (-1)).
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| 10. |
- Ferrara, R, et al.
(författare)
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Atmospheric mercury sources in the Mt. Amiata area, Italy
- 1998
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Ingår i: Science of the Total Environment. - 1879-1026. ; 213:1-3, s. 13-23
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Tidskriftsartikel (refereegranskat)abstract
- Mt. Amiata, located in southern Tuscany (Italy), is part of the geologic anomaly of the Mediterranean basin, which contains about 65% of the world's cinnabar (HgS) deposits. Atmospheric mercury emissions from the main sources (geothermal power plants, abandoned mine structures and spoil banks of roasted cinnabar ore) were determined by flux chamber and by LIDAR remote sensing. Mercury emissions from five geothermal power plants were on the order of 24 g h(-1) for each plant, a value that remains constant throughout the year. In the month of July, the mine spoils (covering an area of similar to 200000 m(2)) emit a few grams of mercury per hour, while the abandoned mine structures give off 100-110 g h(-1). These two mercury sources were strongly influenced by ambient temperature. The area affected by mercury sources displays an average air mercury concentration of 20 ng m(-3) during the summer and 10 ng m(-3) in winter. (C) 1998 Elsevier Science B.V.
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