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Enhanced protection...
Enhanced protection of the renal vascular endothelium improves early outcome in kidney transplantation : Preclinical investigations in pig and mouse
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- Nordling, Sofia, 1985- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Brännström, Johan (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Carlsson, Fredrik (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Lu, Bo (author)
- St Vincents Hosp Melbourne, Immunol Res Ctr, Melbourne, Vic, Australia
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- Salvaris, Evelyn (author)
- St Vincents Hosp Melbourne, Immunol Res Ctr, Melbourne, Vic, Australia
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- Wanders, Alkwin (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Umea, Sweden
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- Buijs, Jos (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Estrada, Sergio (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Tolmachev, Vladimir (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Cowan, Peter J. (author)
- Univ Melbourne, St Vincents Hosp Melbourne, Immunol Res Ctr, Melbourne, Vic, Australia;Univ Melbourne, Dept Med, Melbourne, Vic, Australia
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- Lorant, Tomas, 1975- (author)
- Uppsala universitet,Transplantationskirurgi
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- Magnusson, Peetra U. (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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(creator_code:org_t)
- 2018-03-26
- 2018
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 8
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Ischemia reperfusion injury is one of the major complications responsible for delayed graft function in kidney transplantation. Applications to reduce reperfusion injury are essential due to the widespread use of kidneys from deceased organ donors where the risk for delayed graft function is especially prominent. We have recently shown that coating of inflamed or damaged endothelial cells with a unique heparin conjugate reduces thrombosis and leukocyte recruitment. In this study we evaluated the binding capacity of the heparin conjugate to cultured human endothelial cells, to kidneys from brain-dead porcine donors, and to murine kidneys during static cold storage. The heparin conjugate was able to stably bind cultured endothelial cells with high avidity, and to the renal vasculature of explanted kidneys from pigs and mice. Treatment of murine kidneys prior to transplantation reduced platelet deposition and leukocyte infiltration 24 hours post-transplantation, and significantly improved graft function. The present study thus shows the benefits of enhanced protection of the renal vasculature during cold storage, whereby increasing the antithrombotic and anti-adhesive properties of the vascular endothelium yields improved renal function early after transplantation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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Nordling, Sofia, ...
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Brännström, Joha ...
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Carlsson, Fredri ...
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Lu, Bo
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Salvaris, Evelyn
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Wanders, Alkwin
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Buijs, Jos
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Estrada, Sergio
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Tolmachev, Vladi ...
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Cowan, Peter J.
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Lorant, Tomas, 1 ...
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Magnusson, Peetr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Scientific Repor ...
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Uppsala University
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Umeå University