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| 2. |
- Deng, Min, et al.
(författare)
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Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
- 2013
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
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Tidskriftsartikel (refereegranskat)abstract
- To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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| 3. |
- Ma, Fei, et al.
(författare)
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Association of Leukocyte Telomere Length with Mild Cognitive Impairment and Alzheimer's Disease : Role of Folate and Homocysteine
- 2019
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Ingår i: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 48:1-2, s. 56-67
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Tidskriftsartikel (refereegranskat)abstract
- Background: Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases. The relation of peripheral blood LTL to mild cognitive impairment (MCI) and Alzheimer's disease (AD) and the role of folate and homocysteine (Hcy) in this relation remain unclear.Objectives: We aimed to investigate the association between LTL and the risks of MCI/AD, and to explore whether folate and Hcy may play a role in this association.Methods: This case-control study included 129 MCI subjects, 131 AD patients and 134 healthy controls. LTL was assessed using real-time polymerase chain reaction assay. Serum folate levels were tested by chemiluminescence enzyme immunoassay, and serum Hcy levels were measured using the enzymatic cycling method. Data were analyzed using multivariate logistic regression and multivariable linear regression with adjustment for potential confounders.Results: The mean LTL was 1.56 +/- 0.25 in controls, 1.44 +/- 0.23 in MCI, and 1.28 +/- 0.28 in AD patients (p< 0.01). In multivariate logistic regression, subjects in the longest LTL tertile had lower OR for MCI (OR 0.246; 95% CI 0.101-0.597) and AD (OR 0.123; 95% CI 0.044-0.345) in comparison to subjects in the shortest tertile. Shorter LTL was dose-dependently related to the ORs of MCI and AD. Further, serum folate concentration was positively associated with LTL (p < 0.01), while serum Hcy level was negatively associated with LTL (p < 0.05). In stratified analyses, LTL-MCI/AD association varied by serum folate and Hcy level. Conclusions: Shorter LTL is associated with the risks of MCI/AD. Folate and Hcy might play an important role in this association.
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| 4. |
- Su, Changqing, et al.
(författare)
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Gene-Viral Cancer Therapy Using Dual-Regulated Oncolytic Adenovirus with Antiangiogenesis Gene for Increased Efficacy.
- 2008
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Ingår i: Molecular Cancer Research. - 1557-3125. ; 6, s. 568-575
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Tidskriftsartikel (refereegranskat)abstract
- Conditionally replicative adenovirus (CRAD) represents a promising approach for cancer therapy. Several CRADs controlled by the human telomerase reverse transcriptase promoter have been developed. However, because of their replicative capacity, the importance of cancer specificity for CRADs needs to be further emphasized. In this study, we have developed a novel dual-regulated CRAD, CNHK500-mE, which has its E1a and E1b gene controlled by the human telomerase reverse transcriptase promoter and the hypoxia response element, respectively. It also carries a mouse endostatin expression cassette controlled by the cytomegalovirus promoter. These properties allow for increased cancer cell targeting specificity and decreased adverse side effects. We showed that CNHK500-mE preferentially replicated in cancer cells. Compared with a replication-defective vector carrying the same endostatin expression cassette, CNHK500-mE-mediated transgene expression level was markedly increased via viral replication within cancer cells. In the nasopharyngeal tumor xenograft model, CNHK500-mE injection resulted in antitumor efficacy at day 7 after therapy. Three weeks later, it led to significant inhibition of xenograft tumor growth due to the combined effects of viral oncolytic therapy and antiangiogenesis gene therapy. Pathologic examination showed that most cancer cells were positive for adenoviral capsid protein and for apoptotic terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling in the CNHK500-mE-treated tumor tissues, and the microvessels in these tumor tissues were diminished in quantity and abnormal in morphology. These results suggest that, as a potential cancer therapeutic agent, the CNHK500-mE is endowed with higher specificity to cancer cells and low cytotoxicity to normal cells. (Mol Cancer Res 2008;6(4):OF1-8).
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| 5. |
- Hua, Jiaqi, et al.
(författare)
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A zero-shot prediction method based on causal inference under non-stationary manufacturing environments for complex manufacturing systems
- 2022
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Ingår i: Robotics and Computer-Integrated Manufacturing. - : Elsevier BV. - 0736-5845 .- 1879-2537. ; 77
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Tidskriftsartikel (refereegranskat)abstract
- The state prediction of key components in manufacturing processes plays an important role in intelligent manufacturing, as it could improve the production quality, efficiency and reduce costs. Data-driven methods could learn well-performed prediction models from large volume of data. However, in complex manufacturing systems, the lack of prior knowledge limits the performance of prediction models, where the manufacturing environments changes continuously. In order to address this issue, this paper proposed a zero-shot prediction method for complex manufacturing systems based on causal inference. A deep convolutional neural network and a causal representation model are jointly optimized to extract invariant causal signal features, which can be generalized to non-stationary manufacturing environments without any new data. The experiment of tool wear prediction under non-stationary working conditions is carried out as a research example. The proposed method is verified with the open dataset on tool wear prediction, and experimental results show that the prediction accuracy could be obviously improved over existing methods.
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| 6. |
- Li, Dehua, et al.
(författare)
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An online inference method for condition identification of workpieces with complex residual stress distributions
- 2024
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Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 73, s. 192-204
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Tidskriftsartikel (refereegranskat)abstract
- The residual stress field of structural components significantly influences their comprehensive performance and service life. Due to the lack of effective representation means and inference methods, existing methods are confined to inspecting local residual stress rather than the entire residual stress field, rendering the inference of complex residual stress fields quite difficult. In response to the challenges associated with the requirement for extensive sets of deformation force data from the current workpiece and the inherent difficulty in establishing a stable relationship between deformation forces and residual stress fields, this paper introduces a novel inference method of residual stress field is proposed based on a data-causal knowledge fusion model, where causal knowledge is introduced to eliminate the coupling effect of geometric change on residual stress, which can make up the drawback of pure data driven model. The proposed approach can accurately inference the residual stress within the workpieces, which provides an important basis for deformation control and part property improvement.
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| 7. |
- Ruan, Changqing, et al.
(författare)
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Carbonized cellulose beads for efficient capacitive energy storage
- 2018
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Ingår i: Cellulose. - : Springer Science and Business Media LLC. - 0969-0239 .- 1572-882X. ; 25:6, s. 3545-3556
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Tidskriftsartikel (refereegranskat)abstract
- Natural biomaterials, including polysaccharides and amino acids, provide a sustainable source of functional carbon materials for electric energy storage applications. We present a one-pot reductive amination process to functionalize 2,3-dialdehyde cellulose (DAC) beads with chitosan and l-cysteine to provide single (N)- and dual (N/S)-doped materials. The functionalization enables the physicochemical properties of the materials to be tailored and can provide carbon precursors with heteroatom doping suitable for energy storage applications. Scanning electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis were used to characterize the changes to the beads after functionalization and carbonization. The results of X-ray photoelectron spectroscopy and energy-dispersive X-ray spectroscopy verified that the doping was effective, while the nitrogen sorption isotherms and pore-size distributions of the carbonized beads showed the effects of doping with different hierarchical porosities. In the electrochemical experiments, three kinds of carbon beads [pyrolyzed from DAC, chitosan-crosslinked DAC (CS-DAC) and l-cysteine-functionalized DAC] were used as electrode materials. Electrodes of carbonized CS-DAC beads had a specific capacitance of up to 242 F g(-1) at a current density of 1 A g(-1). These electrodes maintained a capacitance retention of 91.5% after 1000 charge/discharge cycles, suggesting excellent cycling stability. The results indicate that reductive amination of DAC is an effective route for heteroatom doping of carbon materials to be used as electrode active materials for energy storage.
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| 8. |
- Song, Yang, et al.
(författare)
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Unveiling the Enigma of Matter under Extreme Conditions : From Planetary Cores to Functional Materials
- 2023
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Pressure, as one of the fundamental thermodynamic parameters, can profoundly change the interatomic distances, electronic interactions, chemical bonding and crystal structures, leading to exotic structures and properties of materials. High-pressure techniques have significantly impacted disciplines like physics, chemistry, geology, and life science, creating new materials, advancing knowledge of Earth's interior, and influencing pharmaceutical development. This editorial reviews the latest research published in this Collection, highlighting the potential of high-pressure studies to further our understanding of materials' behavior under extreme conditions.
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| 9. |
- Wang, Zhaohui, et al.
(författare)
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Conducting Polymer Paper-Derived Mesoporous 3D N-doped Carbon Current Collectors for Na and Li Metal Anodes : A Combined Experimental and Theoretical Study
- 2018
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Ingår i: The Journal of Physical Chemistry C. - : AMER CHEMICAL SOC. - 1932-7447 .- 1932-7455. ; 122:41, s. 23352-23363
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Tidskriftsartikel (refereegranskat)abstract
- Herein, the manufacturing of a free-standing N-doped mesoporous carbon (CPPY) paper by straightforward carbonization of polypyrrole-coated nanocellulose paper is described. The deposition of Na and Li on these CPPY electrodes, which also serve as current collectors, is studied using a combination of experiments and theoretical calculations. The porous CPPY electrodes gave rise to decreased current densities, which helped to prolong the life-time of the Na electrodes. While the density functional theory calculations suggest that both Na and Li should be deposited uniformly on the CPPY electrodes, the experimental results clearly show that the sodium deposition was more well-defined on the surface of the CPPY electrodes. In contrast to Li, dendrite-free Na depositions could be carried out using deposition capacities up to 12 mAh cm(-2 )and a stable Na electrode cycling performance was found during 1000 h at 1 mA cm(-2). The results suggest that it was difficult to predict the Na or Li deposition behavior merely based on calculations of the metal adsorption energies, as kinetic effects should also be taken into account. Nevertheless, the experimental results clearly show that the use of the present type of porous electrodes provides new possibilities for the development of durable Na electrodes for high-performance sodium metal batteries.
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| 10. |
- Wang, Zhaohui, et al.
(författare)
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Conducting polymer paper-derived separators for lithium metal batteries
- 2018
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Ingår i: Energy Storage Materials. - : Elsevier BV. - 2405-8289 .- 2405-8297. ; 13, s. 283-292
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Tidskriftsartikel (refereegranskat)abstract
- Overoxidised polypyrrole (PPy) paper has been employed as a mesoporous separator for lithium metal batteries (LMBs) based on its narrow pore size distribution, good thermal stability, high ionic conductivity (1.1 mS cm−1 with a LP40 electrolyte) and high electrolyte wettability. The overoxidised PPy paper was produced from a PPy/cellulose composite using a combined base and heat-treatment process, yielding a highly interrupted pyrrole molecular structure including N-containing polar groups maintaining the readily adaptable mesoporous structure of the pristine PPy paper. This well-defined pore structure gave rise to a homogeneous current distribution which significantly increased the performance of a LiFePO4|Li cell. With the overoxidised PPy separator, a symmetric Li|Li cell could be cycled reversibly for more than 600 h without any short-circuits in a LP40 electrolyte. This approach facilitates the manufacturing of well-defined separators for fundamental investigations of the influence of the separator structure on the performance of LMBs.
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