SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wang HS) "

Sökning: WFRF:(Wang HS)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Klionsky, Daniel J., et al. (författare)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • Ingår i: Autophagy. - : Landes Bioscience. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Forskningsöversikt (refereegranskat)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Bixby, H., et al. (författare)
  • Rising rural body-mass index is the main driver of the global obesity epidemic in adults
  • 2019
  • Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 569:7755, s. 260-4
  • Tidskriftsartikel (refereegranskat)abstract
    • Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
  •  
6.
  •  
7.
  • Wang, Zhaoming, et al. (författare)
  • Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
  • 2014
  • Ingår i: Human Molecular Genetics. - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
  •  
8.
  •  
9.
  • Aad, G, et al. (författare)
  • Evidence for Electroweak Production of W^{±}W^{±}jj in pp Collisions at sqrt[s]=8 TeV with the ATLAS Detector.
  • 2014
  • Ingår i: Physical Review Letters. - : American Physical Society. - 1079-7114. ; 113:14
  • Tidskriftsartikel (refereegranskat)abstract
    • This Letter presents the first study of W^{±}W^{±}jj, same-electric-charge diboson production in association with two jets, using 20.3 fb^{-1} of proton-proton collision data at sqrt[s]=8 TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with two reconstructed same-charge leptons (e^{±}e^{±}, e^{±}μ^{±}, and μ^{±}μ^{±}) and two or more jets are analyzed. Production cross sections are measured in two fiducial regions, with different sensitivities to the electroweak and strong production mechanisms. First evidence for W^{±}W^{±}jj production and electroweak-only W^{±}W^{±}jj production is observed with a significance of 4.5 and 3.6 standard deviations, respectively. The measured production cross sections are in agreement with standard model predictions. Limits at 95% confidence level are set on anomalous quartic gauge couplings.
  •  
10.
  • Aad, G., et al. (författare)
  • Light-quark and gluon jet discrimination in collisions at root s=7 TeV with the ATLAS detector
  • 2014
  • Ingår i: European Physical Journal C. Particles and Fields. - : Springer. - 1434-6044 .- 1434-6052. ; 74:8
  • Tidskriftsartikel (refereegranskat)abstract
    • A likelihood-based discriminant for the identification of quark- and gluon-initiated jets is built and validated using 4.7 fb of proton-proton collision data at collected with the ATLAS detector at the LHC. Data samples with enriched quark or gluon content are used in the construction and validation of templates of jet properties that are the input to the likelihood-based discriminant. The discriminating power of the jet tagger is established in both data and Monte Carlo samples within a systematic uncertainty of 10-20 %. In data, light-quark jets can be tagged with an efficiency of while achieving a gluon-jet mis-tag rate of in a range between and for jets in the acceptance of the tracker. The rejection of gluon-jets found in the data is significantly below what is attainable using a Pythia 6 Monte Carlo simulation, where gluon-jet mis-tag rates of 10 % can be reached for a 50 % selection efficiency of light-quark jets using the same jet properties.
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (237)
forskningsöversikt (5)
Typ av innehåll
refereegranskat (237)
övrigt vetenskapligt (5)
Författare/redaktör
Aad, G (121)
Zwalinski, L. (118)
Chen, C. (118)
Chen, H. (113)
Chen, S. (113)
Chen, X. (113)
visa fler...
Francis, D. (110)
Zhang, Z. (109)
Ferrer, A. (109)
Jarlskog, Göran (108)
Adye, T. (108)
Alexander, G. (108)
Antonelli, M. (108)
Asai, S. (108)
Barillari, T. (108)
Barklow, T. (108)
Bartoldus, R. (108)
Bella, G. (108)
Benekos, N. (108)
Bentvelsen, S. (108)
Berger, N. (108)
Besson, N. (108)
Bethke, S. (108)
Biebel, O. (108)
Blumenschein, U. (108)
Boonekamp, M. (108)
Bugge, L. (108)
Calderini, G. (108)
Campana, S. (108)
Cattai, A. (108)
Cavalli-Sforza, M. (108)
Chudoba, J. (108)
Clark, A. (108)
Cowan, G. (108)
Cranmer, K. (108)
Dallapiccola, C. (108)
De Groot, N. (108)
Deluca, C. (108)
Di Ciaccio, L. (108)
Dris, M. (108)
Dubbert, J. (108)
Duckeck, G. (108)
Eigen, G. (108)
Ekelof, T. (108)
Elsing, M. (108)
Etzion, E. (108)
Fassouliotis, D. (108)
Ferrari, P. (108)
Fleck, I. (108)
Fournier, D. (108)
visa färre...
Lärosäte
Lunds universitet (134)
Karolinska Institutet (107)
Kungliga Tekniska Högskolan (101)
Uppsala universitet (32)
Umeå universitet (18)
Högskolan Dalarna (7)
visa fler...
Göteborgs universitet (6)
Linköpings universitet (5)
Stockholms universitet (3)
Chalmers tekniska högskola (3)
Jönköping University (1)
Mittuniversitetet (1)
Högskolan i Skövde (1)
Södertörns högskola (1)
visa färre...
Språk
Engelska (242)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (113)
Medicin och hälsovetenskap (71)
Samhällsvetenskap (2)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy