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Metabotypes Related...
Metabotypes Related to Meat and Vegetable Intake Reflect Microbial, Lipid and Amino Acid Metabolism in Healthy People
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- Wei, Runmin (author)
- University of Hawaii
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- Ross, Alastair, 1976 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Nestle S.A.
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- Su, Ming Ming (author)
- University of Hawaii
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- Wang, Jingye (author)
- University of Hawaii
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- Guiraud, S.P. (author)
- Nestle S.A.
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- Draper, Colleen Fogarty (author)
- Nestle S.A.
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- Beaumont, M. (author)
- Nestle S.A.
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- Jia, Wei (author)
- University of Hawaii
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- Martin, Francois Pierre (author)
- Nestle S.A.
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(creator_code:org_t)
- 2018-08-28
- 2018
- English.
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In: Molecular Nutrition and Food Research. - : Wiley. - 1613-4125 .- 1613-4133. ; 62:21
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https://doi.org/10.1...
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Abstract
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- Scope: The objective of this study is to develop a new methodology to identify the relationship between dietary patterns and metabolites indicative of food intake and metabolism. Methods and results: Plasma and urine samples from healthy Swiss subjects (n = 89) collected over two time points are analyzed for a panel of host–microbial metabolites using GC– and LC–MS. Dietary intake is evaluated using a validated food frequency questionnaire. Dietary pattern clusters and relationships with metabolites are determined using Non-Negative Matrix Factorization (NNMF) and Sparse Generalized Canonical Correlation Analysis (SGCCA). Use of NNMF allows detection of latent diet clusters in this population, which describes a high intake of meat or vegetables. SGCCA associates these clusters to i) diet-host microbial and lipid associated bile acid metabolism, and ii) essential amino acid metabolism. Conclusion: This novel application of NNMF and SGCCA allows detection of distinct metabotypes for meat and vegetable dietary patterns in a heterogeneous population. As many of the metabolites associated with meat or vegetable intake are the result of host–microbiota interactions, the findings support a role for microbiota mediating the metabolic imprinting of different dietary choices.
Subject headings
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- meat intake
- metabolomics
- bile acids
- protein intake
- amino acids
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wei, Runmin
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Ross, Alastair, ...
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Su, Ming Ming
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Wang, Jingye
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Guiraud, S.P.
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Draper, Colleen ...
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show more...
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Beaumont, M.
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Jia, Wei
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Martin, Francois ...
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agriculture Fore ...
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and Food Science
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Molecular Nutrit ...
- By the university
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Chalmers University of Technology