| 1. |
- Yan, Bao-Yong, et al.
(författare)
-
Overexpression of MAC30 in the Cytoplasm of Oral Squamous Cell Carcinoma Predicts Nodal Metastasis and Poor Differentiation
- 2010
-
Ingår i: Chemotherapy. - : S, Karger AG, Basel. - 0009-3157 .- 1421-9794. ; 56:6, s. 424-428
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Expression of the meningioma-associated protein (MAC30) was increased in several types of tumors, including esophageal, gastric and colon tumors, compared to normal tissue. MAC30 expression levels gradually increased from normal colorectal mucosa to primary colorectal cancer and colorectal cancer spreading to the lymph nodes. MAC30 expression was related to survival in patients with colorectal cancer. However, there is no study on MAC30 in oral squamous cell carcinoma (OSCC). Methods: Therefore, MAC30 expression in OSCC was investigated and possible associations of MAC30 expression with clinicopathological variables in OSCC have been analyzed. MAC30 expression was immunohistochemically examined in 20 normal oral mucosa and 43 OSCC specimens. Results: Expression levels of MAC30 in the cytoplasm markedly increased from normal oral epithelial cells to primary OSCC. Strong cytoplasmic staining was significantly higher in primary OSCC compared to normal oral mucosa samples (51 vs. 20%, p = 0.019). Furthermore, MAC30 expression levels in primary tumors of patients with lymph node metastasis exceeded levels in those without metastasis (65 vs. 35%, p = 0.048), and MAC30 expression in poorly differentiated tumors was higher than in well-differentiated ones (90 vs. 39%, p = 0.005). Conclusion: Overexpression of MAC30 in the cytoplasm of OSCC may predict nodal metastasis and poor differentiation.
|
|
| 2. |
- Lu, Xin, et al.
(författare)
-
A generic and modularized Digital twin enabled human-robot collaboration
- 2022
-
Ingår i: Proceedings 2022 IEEE International Conference on e-Business Engineering ICEBE 2022. - : IEEE. - 9781665492447 - 9781665492454 ; , s. 66-73
-
Konferensbidrag (refereegranskat)abstract
- Recently, the manufacturing paradigm shifts from mass production to mass customization, which results in urgently demands for the development of intelligent, flexible and automatic manufacturing systems for handling complex manufacturing tasks with high efficiency. The use of collaborative robots, an essential enabling technology for developing human-robot collaboration (HRC), is on the rise for human-centric intelligent automation design. An effective virtual simulation platform, which can continuously simulate and evaluate HRC performance in different working scenarios, is lacking in developing an HRC system in a sophisticated industrial arena. This paper presents a generic and modularized digital twin enabled HRC framework based on the synergy effect of human, robotic and environment-related factors to provide a flexible, compatible, re-configurable solution to ease the implementation of HRC in the real world. The feasibility of the proposed framework is validated through the practical implementation of a food packaging job, which involves a human operator and an ABB robotic arm collaboratively working together, on an industrial shop.
|
|
| 3. |
- Zhao, Zeng-Ren, et al.
(författare)
-
Overexpression of Id-1 protein is a marker in colorectal cancer progression
- 2008
-
Ingår i: Oncology Reports. - : Spandidos. - 1021-335X .- 1791-2431. ; 19:2, s. 419-424
-
Tidskriftsartikel (refereegranskat)abstract
- Abstract: The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an important role in the regulation of cell proliferation and differentiation. We examined the Id-1 expression by immunohistochemistry in 9 adenomas, 79 primary colorectal adenocarcinomas matched with 40 adjacent normal mucosa specimens and its relationship with clinicopathological factors. The Id-1 expression was increased in the carcinoma compared to the adjacent normal mucosa either in the unmatched and matched samples or to the adenoma. There was no significant difference in the Id-1 expression between normal mucosa and adenoma. The Id-1 expression of carcinoma was increased from Dukes' stages A to B, to C and to D. The cases with lymph node metastasis had a higher rate of a stronger Id-1 expression than those without lymph node metastasis. In conclusion, Id-1 overexpression plays an important role in colorectal cancer progression.
|
|
