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| 2. |
- Abdoullaye, Doukary, et al.
(författare)
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Permanent genetic resources added to molecular ecology resources database 1 August 2009 - 30 September 2009
- 2010
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Ingår i: Molecular Ecology Resources. - : Wiley. - 1755-098X .- 1755-0998. ; 10:1, s. 232-236
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Tidskriftsartikel (refereegranskat)abstract
- This article documents the addition of 238 microsatellite marker loci and 72 pairs of Single Nucleotide Polymorphism (SNP) sequencing primers to the Molecular Ecology Resources Database. Loci were developed for the following species: Adelges tsugae, Artemisia tridentata, Astroides calycularis, Azorella selago, Botryllus schlosseri, Botrylloides violaceus, Cardiocrinum cordatum var. glehnii, Campylopterus curvipennis, Colocasia esculenta, Cynomys ludovicianus, Cynomys leucurus, Cynomys gunnisoni, Epinephelus coioides, Eunicella singularis, Gammarus pulex, Homoeosoma nebulella, Hyla squirella, Lateolabrax japonicus, Mastomys erythroleucus, Pararge aegeria, Pardosa sierra, Phoenicopterus ruber ruber and Silene latifolia. These loci were cross-tested on the following species: Adelges abietis, Adelges cooleyi, Adelges piceae, Pineus pini, Pineus strobi, Tubastrea micrantha, three other Tubastrea species, Botrylloides fuscus, Botrylloides simodensis, Campylopterus hemileucurus, Campylopterus rufus, Campylopterus largipennis, Campylopterus villaviscensio, Phaethornis longuemareus, Florisuga mellivora, Lampornis amethystinus, Amazilia cyanocephala, Archilochus colubris, Epinephelus lanceolatus, Epinephelus fuscoguttatus, Symbiodinium temperate-A clade, Gammarus fossarum, Gammarus roeselii, Dikerogammarus villosus and Limnomysis benedeni. This article also documents the addition of 72 sequencing primer pairs and 52 allele specific primers for Neophocaena phocaenoides.
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| 3. |
- Qin, Danfeng, et al.
(författare)
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N-Doped Hollow Porous Carbon Spheres/Bismuth Hybrid Film Modified Electrodes for Sensitive Voltammetric Determination of Trace Cadmium
- 2018
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Ingår i: Electroanalysis. - : Wiley-VCH Verlagsgesellschaft. - 1040-0397 .- 1521-4109. ; 30:9, s. 1906-1912
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Tidskriftsartikel (refereegranskat)abstract
- In this work, N-doped hollow porous carbon spheres (N-HPCSs) were synthesized by silicon dioxide template-assisted polybenzoxazine (PB) coating strategy. The prepared N-HPCSs have a smooth hollow ball structure surrounded by a well-defined porous shell. Combining with in-situ plating of Bi film, the N-HPCSs were further fabricated a sensitive electrochemical platform for determination trace levels of Cd(II) by differential pulse anodic stripping voltammetry (DPASV). Under the optimized conditions, the Bi-N-HPCSs based sensor displays a linear response to Cd(II) over the range of 0.5gL(-1) to 150gL(-1). Meanwhile, the limit of detection (LOD, S/N=3) is estimated to be around 0.16gL(-1) for Cd(II), which is 31 times lower than the safety values set by United States Environmental Protection Agency (EPA) for the drinking water. Moreover, the proposed method was successfully applied to detection of Cd(II) in tap water and lake water, and the analytical results of the presented method are agreed well with inductively coupled plasma-mass spectrometry (ICP-MS) data. Due to the excellent analytical performance, the fabricated electrode is promised for future development in monitoring of cadmium pollution in the environment.
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| 4. |
- Qin, Danfeng, et al.
(författare)
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Protic salt-based nitrogen-doped mesoporous carbon for simultaneous electrochemical detection of Cd(II) and Pb(II)
- 2017
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Ingår i: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 7:59, s. 36929-36934
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Tidskriftsartikel (refereegranskat)abstract
- Nitrogen-doped mesoporous carbon (NMC) derived from a single small-molecule protic salt (p-phenylenediamine bisulfate) is used for sensing toxic heavy metal ions. Using Nafion, bismuth and NMC to anchor the glassy carbon electrode surface, the fabricate electrode shows high sensitivity for detecting Cd(II) and Pb(II). The limits of detection (S/N = 3) are estimated to be 0.3 mu g L-1 for Cd(II) and 0.4 mu g L-1 for Pb(II), respectively, which are 10 and 25 times lower than the maximum acceptable content for drinking water recommended by the WHO. Furthermore, the sensor is successfully used to analyze Cd(II) and Pb(II) in tap-water with high anti-interference capability and good recovery.
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| 5. |
- Shen, H., et al.
(författare)
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Wearable carbon nanotube devices for sensing
- 2017
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Ingår i: Industrial applications of carbon nanotubes. - : Elsevier. - 9780323415316 - 9780323414814 ; , s. 179-199
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Bokkapitel (refereegranskat)abstract
- The application of carbon nanotubes (CNTs) for wearable sensing device fabrication is an interesting area, attracting sustained scientific and technological interest. Acquisition of information from wearable technologies is considered a cornerstone in person-centered health informatics, because of its independence, currency, and timeliness. The unique physical and chemical properties (such as high aspect ratio, ultralight weight, high mechanical strength, high electrical conductivity, and high thermal conductivity) of CNTs make them an attractive nanomaterial for wearable sensor fabrication. Extensive efforts will continuously be made in both academia and industry in the research and development of wearable CNT sensors to enhance their function, flexibility, energy saving, and longevity. We will discuss recent advances in the design and application of wearable devices based on CNT materials for sensing, especially in the fields of medical equipment, motion detection, and environmental sensor.
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| 6. |
- Zhao, Xiaoyu, et al.
(författare)
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Identification of genetically predicted DNA methylation markers associated with non–small cell lung cancer risk among 34,964 cases and 448,579 controls
- 2024
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Ingår i: Cancer. - : John Wiley & Sons. - 0008-543X .- 1097-0142. ; 130:6, s. 913-926
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Tidskriftsartikel (refereegranskat)abstract
- Background: Although the associations between genetic variations and lung cancer risk have been explored, the epigenetic consequences of DNA methylation in lung cancer development are largely unknown. Here, the genetically predicted DNA methylation markers associated with non–small cell lung cancer (NSCLC) risk by a two-stage case-control design were investigated.Methods: The genetic prediction models for methylation levels based on genetic and methylation data of 1595 subjects from the Framingham Heart Study were established. The prediction models were applied to a fixed-effect meta-analysis of screening data sets with 27,120 NSCLC cases and 27,355 controls to identify the methylation markers, which were then replicated in independent data sets with 7844 lung cancer cases and 421,224 controls. Also performed was a multi-omics functional annotation for the identified CpGs by integrating genomics, epigenomics, and transcriptomics and investigation of the potential regulation pathways.Results: Of the 29,894 CpG sites passing the quality control, 39 CpGs associated with NSCLC risk (Bonferroni-corrected p ≤ 1.67 × 10−6) were originally identified. Of these, 16 CpGs remained significant in the validation stage (Bonferroni-corrected p ≤ 1.28 × 10−3), including four novel CpGs. Multi-omics functional annotation showed nine of 16 CpGs were potentially functional biomarkers for NSCLC risk. Thirty-five genes within a 1-Mb window of 12 CpGs that might be involved in regulatory pathways of NSCLC risk were identified.Conclusions: Sixteen promising DNA methylation markers associated with NSCLC were identified. Changes of the methylation level at these CpGs might influence the development of NSCLC by regulating the expression of genes nearby.Plain Language Summary: The epigenetic consequences of DNA methylation in lung cancer development are still largely unknown. This study used summary data of large-scale genome-wide association studies to investigate the associations between genetically predicted levels of methylation biomarkers and non–small cell lung cancer risk at the first time. This study looked at how well larotrectinib worked in adult patients with sarcomas caused by TRK fusion proteins. These findings will provide a unique insight into the epigenetic susceptibility mechanisms of lung cancer.
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| 7. |
- Ali, Alaa M. G., et al.
(författare)
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Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases
- 2014
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Ingår i: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755 .- 1055-9965. ; 23:6, s. 934-945
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Tidskriftsartikel (refereegranskat)abstract
- Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre-or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. (C) 2014 AACR.
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| 8. |
- Gu, Limin, et al.
(författare)
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Case Studies on the Use of Technology in TPD (Teacher Professional Development)
- 2012
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Ingår i: US-China Education Review. A. - : David Publishing Company. - 2161-623X .- 1548-6613 .- 1930-1529. ; 2:3, s. 278-290
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, the progress of a three-year cooperative project investigating the current state of TPD (teacher professional development) in Sweden and China in the area of TPD and ICT (information and communication technologies) is summarized. A brief introduction to the field of TPD is given, and thereafter, ICT is related to what in the project is referred to as TETPD (Technology Enhanced Teacher Professional Development). Thereafter, the project as such is given a short presentation, followed by findings regarding policies and initiatives related to TETPD in Sweden and China for investigating the current state of TETPD in each country respectively. The framework for investigating TETPD is presented, and four Chinese and four Swedish cases are compared to some facets showing differences in models for TETPD in the two countries.
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| 9. |
- Ho, Joshua W. K., et al.
(författare)
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Comparative analysis of metazoan chromatin organization
- 2014
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 512:7515, s. 449-U507
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Tidskriftsartikel (refereegranskat)abstract
- Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation of chromatin components and mechanisms(1-3). Nevertheless, the three organisms have markedly different genome sizes, chromosome architecture and gene organization. On human and fly chromosomes, for example, pericentric heterochromatin flanks single centromeres, whereas worm chromosomes have dispersed heterochromatin-like regions enriched in the distal chromosomal 'arms', and centromeres distributed along their lengths(4,5). To systematically investigate chromatin organization and associated gene regulation across species, we generated and analysed a large collection of genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human. Here we present over 800 new data sets from our ENCODE and modENCODE consortia, bringing the total to over 1,400. Comparison of combinatorial patterns of histone modifications, nuclear lamina-associated domains, organization of large-scale topological domains, chromatin environment at promoters and enhancers, nucleosome positioning, and DNA replication patterns reveals many conserved features of chromatin organization among the three organisms. We also find notable differences in the composition and locations of repressive chromatin. These data sets and analyses provide a rich resource for comparative and species-specific investigations of chromatin composition, organization and function.
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