| 1. |
- Zhao, Yun, et al.
(författare)
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Rational design of functional binder systems for high-energy lithium-based rechargeable batteries
- 2021
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Ingår i: Energy Storage Materials. - : Elsevier. - 2405-8289 .- 2405-8297. ; 35, s. 353-377
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Tidskriftsartikel (refereegranskat)abstract
- Binders, which maintain the structural integrity of electrodes, are critical components of lithium-based rechargeable batteries (LBRBs) that significantly affect battery performances, despite accounting for 2 to 5 wt% (up to 5 wt% but usually 2 wt%) of the entire electrode. Traditional polyvinylidene fluoride (PVDF) binders that interact with electrode components via weak van der Waals forces are effective in conventional LBRB systems (graphite/LiCoO2, etc.). However, its stable fluorinated structures limit the potential for further functionalization and inhibit strong interactions towards external substances. Consequently, they are unsuitable for next-generation battery systems with high energy density. There is thus a need for new functional binders with facile features compatible with novel electrode materials and chemistries. Here in this review we consider the strategies for rationally designing these functional binders. On the basis of fundamental understandings of the issues for high-energy electrode materials, we have summarized seven desired functions that binders should possess depending on the target electrodes where the binders will be applied. Then a variety of leading-edge functional binders are reviewed to show how their chemical structures realize these above functions and how the employment of these binders affects the cell's electrochemical performances. Finally the corresponding design strategies are therefore proposed, and future research opportunities as well as challenges relating to LBRB binders are outlined.
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| 2. |
- Kirchhoff, Tomas, et al.
(författare)
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Breast cancer risk and 6q22.33 : combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
- 2012
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Ingår i: PLOS ONE. - : Public library of science. - 1932-6203. ; 7:6
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Tidskriftsartikel (refereegranskat)abstract
- Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.
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| 3. |
- Wang, Xianshu, et al.
(författare)
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Non-solvating fluorosulfonyl carboxylate enables temperature-tolerant lithium metal batteries
- 2023
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Ingår i: Journal of Energy Chemistry. - : Elsevier. - 2095-4956 .- 2096-885X. ; 82, s. 287-295
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Tidskriftsartikel (refereegranskat)abstract
- Advanced electrolyte engineering is an important strategy for developing high-efficacy lithium (Li) metal batteries (LMBs). Unfortunately, the current electrolytes limit the scope for creating batteries that perform well over temperature ranges. Here, we present a new electrolyte design that uses fluorosulfonyl carboxylate as a non-solvating solvent to form difluoroxalate borate (DFOB-) anion-rich solvation sheath, to realize high-performance working of temperature-tolerant LMBs. With this optimized electrolyte, favorable SEI and CEI chemistries on Li metal anode and nickel-rich cathode are achieved, respectively, leading to fast Li+ transfer kinetics, dendrite-free Li deposition and suppressed electrolyte deterioration. Therefore, Li||LiNi0.80Co0.15Al0.05O2 batteries with a thin Li foil (50 μm) show a long-term cycling lifespan over 400 cycles at 1 C and a superior capacity retention of 90% after 200 cycles at 0.5 C under 25 ℃. Moreover, this electrolyte extends the operating temperature from -10 to 30 ℃ and significantly improve the capacity retention and Coulombic efficiency of batteries are improved at high temperature (60 ℃). Fluorosulfonyl carboxylates thus have considerable potential for use in high-performance and all-weather LMBs, which broadens the new exploring of electrolyte design.
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| 4. |
- Wu, Junru, et al.
(författare)
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Unique tridentate coordination tailored solvation sheath towards highly stable lithium metal batteries
- 2023
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Ingår i: Advanced Materials. - : Wiley-VCH Verlagsgesellschaft. - 0935-9648 .- 1521-4095. ; 35:38
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Tidskriftsartikel (refereegranskat)abstract
- Electrolyte optimization by solvent molecule design has been recognized as an effective approach for stabilizing lithium (Li) metal batteries. However, the coordination pattern of Li+ with solvent molecules has been sparsely considered. Here, we report an electrolyte design strategy based on bi/tridentate chelation of Li+ and solvent to tune the solvation structure. As a proof of concept, a novel solvent with multi oxygen coordination sites is demonstrated to facilitate the formation of an anion-aggregated solvation shell, enhancing the interfacial stability and de-solvation kinetics. As a result, the as-developed electrolyte exhibits ultra-stable cycling over 1400 h in symmetric cells with 50 ?m-thin Li foils. When paired with high-loading LiFePO4, full cells maintain 92% capacity over 500 cycles and deliver improved electrochemical performances over a wide temperature range from -10 °C to 60 °C. Furthermore, the concept is validated in a pouch cell (570 mAh), achieving a capacity retention of 99.5% after 100 cycles. This brand-new insight on electrolyte engineering provides guidelines for practical high-performance Li metal batteries. This article is protected by copyright. All rights reserved
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| 5. |
- Zhao, Yun, et al.
(författare)
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Precise separation of spent lithium-ion cells in water without discharging for recycling
- 2022
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Ingår i: Energy Storage Materials. - : Elsevier. - 2405-8289 .- 2405-8297. ; 45, s. 1092-1099
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Tidskriftsartikel (refereegranskat)abstract
- New methods for recycling lithium-ion batteries (LIBs) are needed because traditional recycling methods are based on battery pulverization, which requires pre-treatment of tedious and non-eco-friendly discharging and results in low efficiency and high waste generation in post-treatment. Separating the components of recycled LIB cells followed by reuse or conversion of individual components could minimize material cross-contamination while avoiding excessive consumption of energy and chemicals. However, disposing of charged LIB cells is hazardous due to the high reactivity of lithiated graphite towards cathode materials and air, and the toxicity and flammability of the electrolytes. Here we demonstrate that the disassembly of charged jellyroll LIB cells in water with a single main step reveals no emissions from the cells and near perfect recycling efficiencies that exceed the targets of the US Department of Energy and Batteries Europe. The precise non-destructive mechanical method separates the components from jellyroll cell in water, avoiding both uncontrollable reactions from the anode and burning of the electrolyte, while allowing only a limited fraction of the anode lithium to react with water. Recycling in this way allows the recovery of materials with a value of ∼7.14 $ kg−1 cell, which is higher than that of physical separation (∼5.40 $ kg−1 cell) and much greater than the overall revenue achieved using element extraction methods (<1.00 $ kg−1 cell). The precise separation method could thus facilitate the establishment of a circular economy within the LIB industry and build a strong bridge between academia and the battery recycling industry.
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| 6. |
- Antoniou, Antonis C., et al.
(författare)
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Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
- 2011
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 20:16, s. 3304-3321
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Tidskriftsartikel (refereegranskat)abstract
- Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [ hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 x 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 x 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02-1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92-1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women.
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| 7. |
- Stacey, Simon N, et al.
(författare)
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Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.
- 2010
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Ingår i: PLoS genetics. - : Public Library of Science. - 1553-7404. ; 6:7, s. e1001029-
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Tidskriftsartikel (refereegranskat)abstract
- We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other ancestral populations, and genotyped them in breast cancer case:control samples of Asian, European, and African origin, a total of 10,176 cases and 13,286 controls. We found that rs2046210[T] does not confer substantial risk of breast cancer in Europeans and Africans (OR = 1.04, P = 0.099, and OR = 0.98, P = 0.77, respectively). Rather, in those ancestries, an association signal arises from a group of less common SNPs typified by rs9397435. The rs9397435[G] allele was found to confer risk of breast cancer in European (OR = 1.15, P = 1.2 x 10(-3)), African (OR = 1.35, P = 0.014), and Asian (OR = 1.23, P = 2.9 x 10(-4)) population samples. Combined over all ancestries, the OR was 1.19 (P = 3.9 x 10(-7)), was without significant heterogeneity between ancestries (P(het) = 0.36) and the SNP fully accounted for the association signal in each ancestry. Haplotypes bearing rs9397435[G] are well tagged by rs2046210[T] only in Asians. The rs9397435[G] allele showed associations with both estrogen receptor positive and estrogen receptor negative breast cancer. Using early-draft data from the 1,000 Genomes project, we found that the risk allele of a novel SNP (rs77275268), which is closely correlated with rs9397435, disrupts a partially methylated CpG sequence within a known CTCF binding site. These studies demonstrate that shifting the analysis among ancestral populations can provide valuable resolution in association mapping.
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| 8. |
- Walker, Logan C, et al.
(författare)
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Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers.
- 2010
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Ingår i: Breast cancer research : BCR. - : Springer Science and Business Media LLC. - 1465-542X .- 1465-5411. ; 12:6
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Tidskriftsartikel (refereegranskat)abstract
- Current attempts to identify genetic modifiers of BRCA1 and BRCA2 associated risk have focused on a candidate gene approach, based on knowledge of gene functions, or the development of large genome-wide association studies. In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidate modifier genes for association studies.
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