| 1. |
- Luo, Yifei, et al.
(författare)
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Technology Roadmap for Flexible Sensors
- 2023
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Ingår i: ACS Nano. - : American Chemical Society. - 1936-0851 .- 1936-086X. ; 17:6, s. 5211-5295
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Forskningsöversikt (refereegranskat)abstract
- Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.
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| 2. |
- Shi, Chen, et al.
(författare)
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The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID-19 Patients : A Retrospective Cohort Study
- 2020
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Ingår i: Clinical and Translational Science. - : WILEY. - 1752-8054 .- 1752-8062. ; 13:6, s. 1087-1095
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Tidskriftsartikel (refereegranskat)abstract
- On March 11, 2020, the World Health Organization declared its assessment of coronavirus disease 2019 (COVID-19) as a global pandemic. However, specific anti-severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) drugs are still under development, and patients are managed by multiple complementary treatments. We performed a retrospective analysis to compare and evaluate the effect of low molecular weight heparin (LMWH) treatment on disease progression. For this purpose, the clinical records and laboratory indicators were extracted from electronic medical records of 42 patients with COVID-19 (21 of whom were treated with LMWH, and 21 without LMWH) hospitalized (Union Hospital of Huazhong University of Science and Technology) from February 1 to March 15, 2020. Changes in the percentage of lymphocytes before and after LMWH treatment were significantly different from those in the control group (P = 0.011). Likewise, changes in the levels of D-dimer and fibrinogen degradation products in the LMWH group before and after treatment were significantly different from those in the control group (P = 0.035). Remarkably, IL-6 levels were significantly reduced after LMWH treatment (P = 0.006), indicating that, besides other beneficial properties, LMWH may exert an anti-inflammatory effect and attenuate in part the "cytokine storm" induced by the virus. Our results support the use of LMWH as a potential therapeutic drug for the treatment of COVID-19, paving the way for a subsequent well-controlled clinical study.
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| 3. |
- Bernardi, G., et al.
(författare)
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The Future Circular Collider : a Summary for the US 2021 Snowmass Process
- 2022
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In this white paper for the 2021 Snowmass process, we give a description of the proposed Future Circular Collider (FCC) project and its physics program. The paper summarizes and updates the discussion submitted to the European Strategy on Particle Physics. After construction of an approximately 90 km tunnel, an electron-positron collider based on established technologies allows world-record instantaneous luminosities at center-of-mass energies from the Z resonance up to tt thresholds, enabling a rich set of fundamental measurements including Higgs couplings determinations at the sub percent level, precision tests of the weak and strong forces, and searches for new particles, including dark matter, both directly and via virtual corrections or mixing. Among other possibilities, the FCC-ee will be able to (i) indirectly discover new particles coupling to the Higgs and/or electroweak bosons up to scales around 7 and 50 TeV, respectively; (ii) perform competitive SUSY tests at the loop level in regions not accessible at the LHC; (iii) study heavy-flavor and tau physics in ultra-rare decays beyond the LHC reach, and (iv) achieve the best potential in direct collider searches for dark matter, sterile neutrinos, and axion-like particles with masses up to around 90 GeV. The tunnel can then be reused for a proton-proton collider, establishing record center-of-mass collision energy, allowing unprecedented reach for direct searches for new particles up to the around 50 TeV scale, and a diverse program of measurements of the Standard Model and Higgs boson, including a precision measurement of the Higgs self-coupling, and conclusively testing weakly-interacting massive particle scenarios of thermal relic dark matter.
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| 4. |
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| 5. |
- Yin, Ge, et al.
(författare)
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Chlorinated and brominated organic pollutants in shellfish from the Yellow Sea and East China Sea
- 2015
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Ingår i: Environmental Science and Pollution Research. - : Springer Science and Business Media LLC. - 0944-1344 .- 1614-7499. ; 22:3, s. 1713-1722
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Tidskriftsartikel (refereegranskat)abstract
- The global contamination with persistent organic pollutants (POPs), or compounds with similar characteristics, is well known. Still there are data gaps for POP concentrations from many areas in the world. The aim of the present study is to assess several legacies POPs and also hexabromocyclododecane (HBCDD) and methoxylated polybrominated diphenyl ethers (MeO-PBDEs) in shellfish from three locations in the Yellow Sea and East China Sea. The sources of the contaminants are discussed. Pooled samples were treated by liquid-liquid extraction and acid and column cleanup prior to analysis by gas chromatogram equipped with electron capture detector (GC-ECD) and gas chromatography-mass spectrometry (GC-MS). The by far most abundant environmental contaminant originates from dichlorodiphenyltrichloroethane (DDT), independent of species analyzed or sampling site. The results indicate ongoing or at least recent discharges of DDT. The second highest concentrations were reported for HBCDD (21–40 ng/g fat) in the shellfish, independent of sampling sites. The two natural products, 6-MeO-BDE-47 and 2′-MeO-BDE-68, were also present in the shellfish (1.3–22 and 1–14 ng/g fat, respectively). The polychlorinated biphenyl (PCB) congener CB-153 (0.8–6.5 ng/g fat), hexachlorobenzene (HCB) (1.1–3.6 ng/g fat), and β-hexachlorocyclohexane (β-HCH) (2.3–4.9 ng/g fat) were all higher than the concentrations of other HCH isomers, β-endosulfan, PBDE congeners, and mirex. Apart from the DDTs and HBCDDs, it is evident that the pollution of shellfish was similar to, or lower than, the contamination of shellfish in other parts of the world.
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