Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases : a multinational cohort study

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Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases : a multinational cohort study

Freisling, Heinz (author): International Agency for Research on Cancer, World Health Organization

Viallon, Vivian (author): International Agency for Research on Cancer, World Health Organization

Lennon, Hannah (author): International Agency for Research on Cancer, World Health Organization

Bagnardi, Vincenzo (author): University of Milano-Bicocca

Ricci, Cristian (author): North-West University

Butterworth, Adam S. (author): University of Cambridge

Sweeting, Michael (author): University of Cambridge

Muller, David (author): Imperial College London

Romieu, Isabelle (author): International Agency for Research on Cancer, World Health Organization

Bazelle, Pauline (author): International Agency for Research on Cancer, World Health Organization

Kvaskoff, Marina (author): University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)

Arveux, Patrick (author): Centre Georges-François Leclerc,Centre for Research in Epidemiology and Population Health (CESP),Breast and Gynaecologic Cancer Registry of Côte d'Or

Severi, Gianluca (author): University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP),Human Genetics Foundation (HuGeF)

Bamia, Christina (author): Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens

Kühn, Tilman (author): German Cancer Research Centre

Kaaks, Rudolf (author): German Cancer Research Centre

Bergmann, Manuela (author): German Institute of Human Nutrition

Boeing, Heiner (author): German Institute of Human Nutrition

Tjønneland, Anne (author): Danish Cancer Society

Olsen, Anja (author): Danish Cancer Society

Overvad, Kim (author): Aarhus University

Dahm, Christina C. (author): Aarhus University

Menéndez, Virginia (author): Public Health Directorate

Agudo, Antonio (author): Bellvitge Biomedical Research Institute,L'Hospitalet de Llobregat, Barcelona,Bellvitge University Hospital-IDIBELL,University of Oxford

Sánchez, Maria Jose (author): CIBER Epidemiology and Public Health (CIBERESP),University of Granada

Amiano, Pilar (author): CIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute

Santiuste, Carmen (author): Murcia Regional Health Council

Gurrea, Aurelio Barricarte (author): CIBER Epidemiology and Public Health (CIBERESP)

Tong, Tammy Y.N. (author): University of Oxford

Schmidt, Julie A. (author): University of Oxford

Tzoulaki, Ioanna (author): Imperial College London,University of Ioannina

Tsilidis, Konstantinos K. (author): Imperial College London,University of Ioannina

Ward, Heather (author): Imperial College London

Palli, Domenico (author): Institute for Cancer Research, Prevention and Clinical Network (ISPRO)

Agnoli, Claudia (author): Istituto Nazionale dei Tumori

Tumino, Rosario (author): Civic and M.P Arezzo Hospital

Ricceri, Fulvio (author): Citta' della Salute e della Scienza Hospital-University of Turin

Panico, Salvatore (author): University of Naples Federico II

Picavet, H. Susan J. (author): National Institute for Public Health and the Environment (RIVM)

Bakker, Marije (author): University Medical Center Utrecht

Monninkhof, Evelyn (author): University Medical Center Utrecht

Nilsson, Peter (author): Umeå universitet,Umeå University,Näringsforskning

Manjer, Jonas (author): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital

Rolandsson, Olov (author): Umeå universitet,Umeå University,Allmänmedicin

Thysell, Elin (author): Umeå University

Weiderpass, Elisabete (author): International Agency for Research on Cancer, World Health Organization

Jenab, Mazda (author): International Agency for Research on Cancer, World Health Organization

Riboli, Elio (author): Imperial College London

Vineis, Paolo (author): Imperial College London

Danesh, John (author): University of Cambridge

Wareham, Nick J (author): University of Cambridge

Gunter, Marc J. (author): International Agency for Research on Cancer, World Health Organization

Ferrari, Pietro (author): International Agency for Research on Cancer, World Health Organization

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(creator_code:org_t)

2020-01-10
2020
English.
In: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 18:1

Related links:: http://dx.doi.org/10... (free); show more...; https://bmcmedicine....; https://doi.org/10.1...; https://umu.diva-por... (primary) (Raw object); https://lup.lub.lu.s...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. METHODS: In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. RESULTS: During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and women with healthy lifestyles. CONCLUSION: Pre-diagnostic healthy lifestyle behaviours were strongly inversely associated with the risk of cancer and cardiometabolic diseases, and with the prognosis of these diseases by reducing risk of multimorbidity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

Cancer
Cancer and cardiometabolic multimorbidity
Cardiovascular disease
Diabetes
Healthy lifestyle
Obesity
Prevention
Cancer

Publication and Content Type

art (subject category)
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By the author/editor: Freisling, Heinz; Viallon, Vivian; Lennon, Hannah; Bagnardi, Vincen ...; Ricci, Cristian; Butterworth, Ada ...; show more...; Sweeting, Michae ...; Muller, David; Romieu, Isabelle; Bazelle, Pauline; Kvaskoff, Marina; Arveux, Patrick; Severi, Gianluca; Bamia, Christina; Kühn, Tilman; Kaaks, Rudolf; Bergmann, Manuel ...; Boeing, Heiner; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Dahm, Christina ...; Menéndez, Virgin ...; Agudo, Antonio; Sánchez, Maria J ...; Amiano, Pilar; Santiuste, Carme ...; Gurrea, Aurelio ...; Tong, Tammy Y.N.; Schmidt, Julie A ...; Tzoulaki, Ioanna; Tsilidis, Konsta ...; Ward, Heather; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvator ...; Picavet, H. Susa ...; Bakker, Marije; Monninkhof, Evel ...; Nilsson, Peter; Manjer, Jonas; Rolandsson, Olov; Thysell, Elin; Weiderpass, Elis ...; Jenab, Mazda; Riboli, Elio; Vineis, Paolo; Danesh, John; Wareham, Nick J; Gunter, Marc J.; Ferrari, Pietro; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

Articles in the publication: BMC Medicine

By the university: Lund University; Umeå University

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