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Serological reactiv...
Serological reactivity to Anaplasma phagocytophilum in neoehrlichiosis patients
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- Wass, Linda (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Infect Dis, Gothenburg, Sweden
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- Grankvist, Anna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Infect Dis, Gothenburg, Sweden
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- Mattsson, Mattias (author)
- Uppsala universitet,Hematologi
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- Gustafsson, H. (author)
- Gavle Cent Hosp, Dept Hematol, Gavle, Sweden
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- Krogfelt, K. (author)
- Statens Serum Inst, Dept Bacteria Parasites & Fungi, Copenhagen, Denmark
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- Olsen, Björn (author)
- Uppsala universitet,Infektionssjukdomar,Klinisk mikrobiologi
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- Nilsson, Kenneth, Docent, 1953- (author)
- Uppsala universitet,Infektionssjukdomar,Klinisk mikrobiologi
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- Mårtensson, Andreas, 1963- (author)
- Uppsala universitet,Internationell barnhälsa och nutrition
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- Quarsten, H. (author)
- Sorlandet Hosp Hlth Enterprise, Dept Med Microbiol, Kristiansand, Norway
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- Henningsson, A. J. (author)
- Cty Hosp Ryhov, Dept Clin Microbiol, Jonkoping, Sweden
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- Wennerås, Christine, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Infect Dis, Gothenburg, Sweden;Sahlgrens Univ Hosp, Dept Clin Microbiol, Guldhedsgatan 10, S-41346 Gothenburg, Sweden
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(creator_code:org_t)
- 2018-06-14
- 2018
- English.
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In: European Journal of Clinical Microbiology & Infectious Diseases. - : Springer Science and Business Media LLC. - 0934-9723 .- 1435-4373. ; 37:9, s. 1673-1678
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Abstract
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- The tick-borne bacterium Candidatus (Ca.) Neoehrlichia (N.) mikurensis is a cause of "fever of unknown origin" because this strict intracellular pathogen escapes detection by routine blood cultures. Case reports suggest that neoehrlichiosis patients may display serological reactivity to Anaplasma (A.) phagocytophilum. Since Anaplasma serology is part of the diagnostic work-up of undetermined fever in European tick-exposed patients, we wanted to investigate (1) the prevalence of A. phagocytophilum seropositivity among neoehrlichiosis patients, (2) the frequency of misdiagnosed neoehrlichiosis patients among A. phagocytophilum seropositive patients, and (3) the frequency of A. phagocytophilum and Ca. N. mikurensis co-infections. Neoehrlichiosis patients (n = 18) were analyzed for A. phagocytophilum IgM and IgG serum antibodies by indirect immunofluorescence assay. Serum samples from suspected anaplasmosis patients (n = 101) were analyzed for bacterial DNA contents by singleplex PCR specific for A. phagocytophilum and Ca. N. mikurensis, respectively. One fifth of the neoehrlichiosis patients (4/18) were seropositive for IgM and/or IgG to A. phagocytophilum at the time of diagnosis. Among the patients with suspected anaplasmosis, 2% (2/101) were positive for Ca. N. mikurensis by PCR whereas none (0/101) had detectable A. phagocytophilum DNA in the serum. To conclude, patients with suspected anaplasmosis may in fact have neoehrlichiosis. We found no evidence of A. phagocytophilum and Ca. N. mikurensis co-infections in humans with suspected anaplasmosis or confirmed neoehrlichiosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- human granulocytic ehrlichiosis
- borrelia-burgdorferi
- mikurensis
- tick
- infections
- sweden
- seroprevalence
- humans
- norway
- europe
- Infectious Diseases
- Microbiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Wass, Linda
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Grankvist, Anna
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Mattsson, Mattia ...
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Gustafsson, H.
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Krogfelt, K.
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Olsen, Björn
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Nilsson, Kenneth ...
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Mårtensson, Andr ...
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Quarsten, H.
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Henningsson, A. ...
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Wennerås, Christ ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Hematology
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University of Gothenburg
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Uppsala University