| 1. |
- Locke, Adam E, et al.
(författare)
-
Genetic studies of body mass index yield new insights for obesity biology.
- 2015
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
-
Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
|
|
| 2. |
- Peter, Christian, et al.
(författare)
-
Sensing Mood to Counteract Dementia
- 2007
-
Ingår i: International Workshop on Pervasive Technologies for the support of Alzheimer's Disease and Related Disorders.
-
Konferensbidrag (refereegranskat)
|
|
| 3. |
- Lango Allen, Hana, et al.
(författare)
-
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
- 2010
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 467:7317, s. 832-8
-
Tidskriftsartikel (refereegranskat)abstract
- Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P < 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
|
|
| 4. |
- Sandlund, Marlene, 1972-, et al.
(författare)
-
Using motion interactive games to promote physical activity and enhance motor performance in children with cerebral palsy
- 2011
-
Ingår i: Developmental Neurorehabilitation. - : Taylor & Francis. - 1751-8423 .- 1751-8431. ; 14:1, s. 15-21
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To explore the feasibility of using low-cost motion interactive games as a home-based intervention for children with cerebral palsy (CP).Methods: Fourteen children with CP, 6–16 years old, practiced with the EyeToy for PlayStation2® in their homes during 4 weeks. Outcome measures were physical activity monitors, Movement Assessment Battery for Children-2 (mABC-2), Bruininks-Oseretsky Test of Motor Proficiency (sub-test 5 : 6), 1 Minute Walk Test and gaming diaries.Results: Motivation for practice and compliance of training were high. The children's physical activity increased during the intervention and activity monitors were feasible to use, although data loss may be a concern. According to mABC-2 the children's motor performance improved, but there were both floor and ceiling effects. The two additional motor tests showed only non-significant progress.Conclusion: It is highly feasible to use motion interactive games in home rehabilitation for children with CP. Specific motor effects need to be further explored.
|
|
| 5. |
- Winge, Monica, et al.
(författare)
-
CO-CARE - Collaborative Health and Social Care
- 2008
-
Ingår i: Proceedings of the 13th International Symposium for Health Information Management Research. - Palmerston North, New Zealand : Massey University. - 9780473141738 ; , s. 113-124
-
Konferensbidrag (refereegranskat)abstract
- In this paper we discuss the fact that more and more patients are treated in their homes by a set of organizations, sometimes with different ownership. We explore how this poses new and stronger demands on health care and home service staff, as well as on different managerial and operational levels, to improve their communication and collaboration. We emphasize the need for managers in different organizations to agree on ways and forms of communication and collaboration between the operational levels, and the particular importance of this during procurement of home care services. As a result a number of methodological measures, strategies and IT solutions to support organizational development, coordination and collaboration are suggested.
|
|
| 6. |
- Winge, Monica, et al.
(författare)
-
Interorganisational Collaboration in Home Care : A First Discussion of Requirements
- 2007
-
Ingår i: Proceedings of the 12th International Symposium on Health Information Management Research (ISHIMR 2007, Sheffield, UK). - Sheffield : University of Sheffield. - 0903522403 ; , s. 43-50
-
Konferensbidrag (refereegranskat)abstract
- In this paper we discuss the fact that more and more patients are treated in their homes instead of in a hospital, and by a whole set of organizations, sometimes with different ownership, and how this fact places new and heavy demands on health care and home service staff to communicate and to collaborate. We further discuss the need for communication and collaboration on both managerial and operational levels. In particular we point to the need for managers in different organizations to agree on ways of communicating and collaborating on the operational level and how this aspect has to be taken into account already during procurement of home care services. We finally give a brief account of IT support for collaboration and coordination that may help to improving the situation.
|
|
| 7. |
|
|
| 8. |
- Winge, Monica, et al.
(författare)
-
A New Care Concept : Making Collaborative Home Care Work
- 2007
-
Ingår i: Proceedings from the 6th International Conference on Perspectives in Business Informatics Research. - Tampere : Department of Computer Science, University of Tampere. - 9789514471216 ; , s. 158-169
-
Konferensbidrag (refereegranskat)
|
|
| 9. |
- Winge, Monica, et al.
(författare)
-
Co-Care : Collaborative health and social care
- 2008
-
Ingår i: Proceedings of the 13th International Symposium for Health Information Management Research. - : Massey University. - 9780473141738 ; , s. 113-124
-
Konferensbidrag (refereegranskat)
|
|
| 10. |
- Sandlund, Marlene, et al.
(författare)
-
Interactive games in motor rehabilitation for children with sensor motor disorders
- 2007
-
Ingår i: 2007 virtual rehabilitation. - New York : IEEE conference proceedings. - 9781424412044 ; , s. 78-78
-
Konferensbidrag (refereegranskat)abstract
- Interactive computer environments may be a good way to make motor practice more fun and motivating for children with sensorimotor disorders. However, appropriate computer environments that could be used for this purpose need to be systematically tested in rehabilitation settings in order to evaluate their impact on motor aspects as well as on motivation and activity levels. This abstract describes pilot data from an ongoing intervention study involving children diagnosed with cerebral palsy. The interactive environment used is the Sony's EyeToy system for PlayStation2. The intervention is evaluated through interviews as well as with activity monitoring and motor assessments, including 3D motion analysis. Here we will report pilot data based on the interviews.
|
|
