SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Watts Nick) ;lar1:(ki)"

Sökning: WFRF:(Watts Nick) > Karolinska Institutet

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Palmer, Duncan S., et al. (författare)
  • Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
  • 2022
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 54:5, s. 541-547
  • Tidskriftsartikel (refereegranskat)abstract
    • We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We find an excess of ultra-rare protein-truncating variants (PTVs) in patients with BD among genes under strong evolutionary constraint in both major BD subtypes. We find enrichment of ultra-rare PTVs within genes implicated from a recent schizophrenia exome meta-analysis (SCHEMA; 24,248 cases and 97,322 controls) and among binding targets of CHD8. Genes implicated from genome-wide association studies (GWASs) of BD, however, are not significantly enriched for ultra-rare PTVs. Combining gene-level results with SCHEMA, AKAP11 emerges as a definitive risk gene (odds ratio (OR) = 7.06, P = 2.83 × 10−9). At the protein level, AKAP-11 interacts with GSK3B, the hypothesized target of lithium, a primary treatment for BD. Our results lend support to BD’s polygenicity, demonstrating a role for rare coding variation as a significant risk factor in BD etiology.
  •  
2.
  • Schweinsberg, Martin, et al. (författare)
  • Same data, different conclusions : Radical dispersion in empirical results when independent analysts operationalize and test the same hypothesis
  • 2021
  • Ingår i: Organizational Behavior and Human Decision Processes. - : Elsevier BV. - 0749-5978 .- 1095-9920. ; 165, s. 228-249
  • Tidskriftsartikel (refereegranskat)abstract
    • In this crowdsourced initiative, independent analysts used the same dataset to test two hypotheses regarding the effects of scientists' gender and professional status on verbosity during group meetings. Not only the analytic approach but also the operationalizations of key variables were left unconstrained and up to individual analysts. For instance, analysts could choose to operationalize status as job title, institutional ranking, citation counts, or some combination. To maximize transparency regarding the process by which analytic choices are made, the analysts used a platform we developed called DataExplained to justify both preferred and rejected analytic paths in real time. Analyses lacking sufficient detail, reproducible code, or with statistical errors were excluded, resulting in 29 analyses in the final sample. Researchers reported radically different analyses and dispersed empirical outcomes, in a number of cases obtaining significant effects in opposite directions for the same research question. A Boba multiverse analysis demonstrates that decisions about how to operationalize variables explain variability in outcomes above and beyond statistical choices (e.g., covariates). Subjective researcher decisions play a critical role in driving the reported empirical results, underscoring the need for open data, systematic robustness checks, and transparency regarding both analytic paths taken and not taken. Implications for orga-nizations and leaders, whose decision making relies in part on scientific findings, consulting reports, and internal analyses by data scientists, are discussed.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Liu, Yang (1)
Jonsson, Lina, 1982 (1)
Nilsonne, Gustav (1)
van den Akker, Olmo ... (1)
Schweinsberg, Martin (1)
Silberzahn, Raphael (1)
visa fler...
Uhlmann, Eric Luis (1)
Adolfsson, Rolf (1)
Pedersen, Nancy L (1)
Danielsson, Henrik, ... (1)
Locke, Adam E. (1)
Miller, David (1)
Reif, Andreas (1)
Goes, Fernando S (1)
Zandi, Peter P (1)
Robinson, David (1)
Bahník, Štěpán (1)
van Aert, Robbie C. ... (1)
van Assen, Marcel A. ... (1)
Singh, Tarjinder (1)
Risch, Neil (1)
Freimer, Nelson B (1)
Villeseche, Florence (1)
Zandian, Arash (1)
Clark, Michael (1)
Churchhouse, Claire (1)
Neale, Benjamin M (1)
Schaefer, Catherine (1)
Viganola, Domenico (1)
Jones, Ian (1)
Ophoff, Roel A (1)
Owen, Michael J. (1)
Corvin, Aiden P. (1)
Morris, Derek W. (1)
Kane, David (1)
Posthuma, Danielle (1)
Gnambs, Timo (1)
Stahl, Eli A (1)
Chen, Chia-Yen (1)
Smoller, Jordan W (1)
Heer, Jeffrey (1)
McQuillin, Andrew (1)
O'Donovan, Michael C ... (1)
Cyrus-Lai, Wilson (1)
Kahn, René S. (1)
McIntosh, Andrew M (1)
Craddock, Nicholas (1)
Landén, Mikael (1)
Walters, James T R (1)
Feldman, Michael (1)
visa färre...
Lärosäte
Karolinska Institutet  (2)Ta bort avgränsningen
Göteborgs universitet (1)
Umeå universitet (1)
Kungliga Tekniska Högskolan (1)
Stockholms universitet (1)
Linköpings universitet (1)
visa fler...
Handelshögskolan i Stockholm (1)
visa färre...
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
Medicin och hälsovetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy