SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Webster John) ;lar1:(su)"

Sökning: WFRF:(Webster John) > Stockholms universitet

  • Resultat 1-3 av 3
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • 2019
  • Tidskriftsartikel (refereegranskat)
  •  
2.
  • Ma, Jianhui, et al. (författare)
  • Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
  • 2019
  • Ingår i: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 35:3, s. 504-518.e7
  • Tidskriftsartikel (refereegranskat)abstract
    • Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resistance mediated by phosphorylation of PTEN on tyrosine 240 (pY240-PTEN) by FGFR2. pY240-PTEN is rapidly elevated and bound to chromatin through interaction with Ki-67 in response to IR treatment and facilitates the recruitment of RAD51 to promote DNA repair. Blocking Y240 phosphorylation confers radiation sensitivity to tumors and extends survival in GBM preclinical models. Y240F-Pten knockin mice showed radiation sensitivity. These results suggest that FGFR-mediated pY240-PTEN is a key mechanism of radiation resistance and is an actionable target for improving radiotherapy efficacy.
  •  
3.
  • Sedlar, Joseph, et al. (författare)
  • Confronting Arctic Troposphere, Clouds, and Surface Energy Budget Representations in Regional Climate Models With Observations
  • 2020
  • Ingår i: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 125:6
  • Tidskriftsartikel (refereegranskat)abstract
    • A coordinated regional climate model (RCM) evaluation and intercomparison project based on observations from a July-October 2014 trans-Arctic Ocean field experiment (ACSE-Arctic Clouds during Summer Experiment) is presented. Six state-of-the-art RCMs were constrained with common reanalysis lateral boundary forcing and upper troposphere nudging techniques to explore how the RCMs represented the evolution of the surface energy budget (SEB) components and their relation to cloud properties. We find that the main reasons for the modeled differences in the SEB components are a direct consequence of the RCM treatment of cloud and cloud-radiative interactions. The RCMs could be separated into groups by their overestimation or underestimation of cloud liquid. While radiative and turbulent heat flux errors were relatively large, they often invoke compensating errors. In addition, having the surface sea-ice concentrations constrained by the reanalysis or satellite observations limited how errors in the modeled radiative fluxes could affect the SEB and ultimately the surface evolution and its coupling with lower tropospheric mixing and cloud properties. Many of these results are consistent with RCM biases reported in studies over a decade ago. One of the six models was a fully coupled ocean-ice-atmosphere model. Despite the biases in overestimating cloud liquid, and associated SEB errors due to too optically thick clouds, its simulations were useful in understanding how the fully coupled system is forced by, and responds to, the SEB evolution. Moving forward, we suggest that development of RCM studies need to consider the fully coupled climate system.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-3 av 3
Typ av publikation
tidskriftsartikel (3)
Typ av innehåll
refereegranskat (3)
Författare/redaktör
Kelly, Daniel (1)
Bengtsson-Palme, Joh ... (1)
Nilsson, Henrik (1)
Kelly, Ryan (1)
Li, Ying (1)
Moore, Matthew D. (1)
visa fler...
Liu, Fang (1)
Zhang, Yao (1)
Jin, Yi (1)
Raza, Ali (1)
Rafiq, Muhammad (1)
Zhang, Kai (1)
Khatlani, T (1)
Kahan, Thomas (1)
Tjernström, Michael (1)
Sörelius, Karl, 1981 ... (1)
Batra, Jyotsna (1)
Roobol, Monique J (1)
Backman, Lars (1)
Yan, Hong (1)
Schmidt, Axel (1)
Lorkowski, Stefan (1)
Thrift, Amanda G. (1)
Zhang, Wei (1)
Hammerschmidt, Sven (1)
Patil, Chandrashekha ... (1)
Wang, Jun (1)
Pollesello, Piero (1)
Conesa, Ana (1)
El-Esawi, Mohamed A. (1)
Zhang, Weijia (1)
Li, Jian (1)
Marinello, Francesco (1)
Frilander, Mikko J. (1)
Wei, Pan (1)
Badie, Christophe (1)
Zhao, Jing (1)
Li, You (1)
Bansal, Abhisheka (1)
Rinke, Annette (1)
Matthes, Heidrun (1)
Cassano, John (1)
Fettweis, Xavier (1)
Rahman, Proton (1)
Parchi, Piero (1)
Polz, Martin (1)
Ijzerman, Adriaan P. (1)
Subhash, Santhilal, ... (1)
Quinn, Terence J. (1)
Uversky, Vladimir N. (1)
visa färre...
Lärosäte
Stockholms universitet  (3)Ta bort avgränsningen
Göteborgs universitet (1)
Kungliga Tekniska Högskolan (1)
Uppsala universitet (1)
Högskolan i Halmstad (1)
Lunds universitet (1)
visa fler...
Chalmers tekniska högskola (1)
Karolinska Institutet (1)
visa färre...
Språk
Engelska (3)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (3)
Medicin och hälsovetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy