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Estrogen receptor a...
Estrogen receptor alpha gene polymorphism and endometrial cancer risk : a case-control study
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- Wedrén, Sara (author)
- Karolinska Institutet
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- Lovmar, Lovisa (author)
- Uppsala universitet,Molekylär medicin
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- Humphreys, Keith (author)
- Karolinska Institutet
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- Magnusson, Cecilia (author)
- Karolinska Institutet
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- Melhus, Håkan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical pharmacogenetics and osteoporosis
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin
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- Kindmark, Andreas (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Metabolic Bone Diseases
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- Landegren, Ulf (author)
- Uppsala universitet,Molekylära verktyg
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Fermér, Maria Lagerström (author)
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- Stiger, Fredrik (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical pharmacogenetics and osteoporosis
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Persson, Ingemar (author)
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Baron, John A. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2008-11-06
- 2008
- English.
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In: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 8, s. 322-
- Related links:
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https://bmccancer.bi...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- BACKGROUND: Estrogen is an established endometrial carcinogen. One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen receptor alpha gene (ESR1) is associated with endometrial cancer risk. METHODS: In 702 cases with invasive endometrial cancer and 1563 controls, we genotyped five markers in ESR1 and used logistic regression models to estimate odds ratios (OR) and 95 percent confidence intervals (CI). RESULTS: We found an association between rs2234670, rs2234693, as well as rs9340799, markers in strong linkage disequilibrium (LD), and endometrial cancer risk. The association with rs9340799 was the strongest, OR 0.75 (CI 0.60-0.93) for heterozygous and OR 0.53 (CI 0.37-0.77) for homozygous rare compared to those homozygous for the most common allele. Haplotype models did not fit better to the data than single marker models. CONCLUSION: We found that intronic variation in ESR1 was associated with endometrial cancer risk.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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BMC Cancer
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To the university's database
- By the author/editor
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Wedrén, Sara
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Lovmar, Lovisa
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Humphreys, Keith
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Magnusson, Cecil ...
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Melhus, Håkan
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Syvänen, Ann-Chr ...
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show more...
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Kindmark, Andrea ...
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Landegren, Ulf
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Fermér, Maria La ...
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Stiger, Fredrik
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Persson, Ingemar
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Baron, John A.
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Weiderpass, Elis ...
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- Articles in the publication
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BMC Cancer
- By the university
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Uppsala University
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Karolinska Institutet