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Parental occupation...
Parental occupational exposure to pesticides and the risk of childhood leukemia in Costa Rica
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Monge, Patricia (författare)
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Wesseling, Catharina (författare)
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Guardado, Jorge (författare)
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- Lundberg, Ingvar (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Eva Vingård
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- Ahlbom, Anders (författare)
- Karolinska Institutet
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Cantor, Kenneth P. (författare)
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Weiderpass, Elisabete (författare)
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Partanen, Timo (författare)
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(creator_code:org_t)
- Scandinavian Journal of Work, Environment and Health, 2007
- 2007
- Engelska.
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Ingår i: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 33:4, s. 293-303
- Relaterad länk:
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http://www.ncbi.nlm....
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https://www.sjweh.fi...
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: Parental exposure to pesticides and the risk of leukemia in offspring were examined in a population-based case-control study in Costa Rica. METHODS: All cases of childhood leukemia (N=334), in 1995-2000, were identified at the Cancer Registry and the Children's Hospital. Population controls (N=579) were drawn from the National Birth Registry. Interviews of parents were conducted using conventional and icon-based calendar forms. An exposure model was constructed for 25 pesticides in five time periods. RESULTS: Mothers' exposures to any pesticides during the year before conception and during the first and second trimesters were associated with the risk [odds ratio (OR) 2.4, 95% confidence interval (95% CI) 1.0-5.9; OR 22, 95% CI 2.8-171.5; OR 4.5, 95% CI 1.4-14.7, respectively] and during anytime (OR 2.2, 95% CI 1.0-4.8). An association was found for fathers' exposures to any pesticides during the second trimester (OR 1.5, 95% CI 1.0-2.3). An increased risk with respect to organophosphates was found for mothers during the first trimester (OR 3.5, 95% CI 1.0-12.2) and for fathers during the year before conception and the first trimester (OR 1.5, 95% CI 1.0-2.2 and OR 1.6, 95% CI 1.0-2.6, respectively), and benzimidazoles during the first, second, and third trimesters of pregnancy (OR 2.2, 95% CI 1.0-4.4; OR 2.2, 95% CI 1.0-5.0; OR 2.2, 95% CI 1.0-5.2, respectively). There was a suggestion of an exposure-response gradient for fathers as regards picloram, benomyl, and paraquat. Age at diagnosis was positively associated with fathers' exposures and inversely associated with mothers' exposures. CONCLUSIONS: The results suggest that parental exposure to certain pesticides may increase the risk of leukemia in offspring.
Nyckelord
- Adolescent
- Child
- Child; Preschool
- Costa Rica/epidemiology
- Female
- Humans
- Infant
- Infant; Newborn
- Interviews as Topic
- Leukemia/epidemiology/*etiology
- Male
- Occupational Exposure
- Odds Ratio
- Parents
- Pesticides/*adverse effects
- Registries
- Risk Assessment
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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