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Quantitative trait ...
Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).
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Ahn, Jiyoung (author)
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Schumacher, Fredrick R (author)
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Berndt, Sonja I (author)
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Pfeiffer, Ruth (author)
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Albanes, Demetrius (author)
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Andriole, Gerald L (author)
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Ardanaz, Eva (author)
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Boeing, Heiner (author)
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Bueno-de-Mesquita, Bas (author)
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Chanock, Stephen J (author)
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Clavel-Chapelon, Françoise (author)
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Diver, W Ryan (author)
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Feigelson, Heather Spencer (author)
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Gaziano, J Michael (author)
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Giovannucci, Edward (author)
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Haiman, Christopher A (author)
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Henderson, Brian E (author)
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Hoover, Robert N (author)
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Kolonel, Laurence N (author)
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Kraft, Peter (author)
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Ma, Jing (author)
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Le Marchand, Loïc (author)
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Overvad, Kim (author)
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Palli, Domenico (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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Stampfer, Meir (author)
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Stram, Daniel O (author)
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Thomas, Gilles (author)
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Thun, Michael J (author)
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Travis, Ruth C (author)
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Trichopoulos, Dimitrios (author)
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Virtamo, Jarmo (author)
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Weinstein, Stephanie J (author)
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Yeager, Meredith (author)
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Kaaks, Rudolf (author)
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Hunter, David J (author)
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Hayes, Richard B (author)
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(creator_code:org_t)
- 2009-07-02
- 2009
- English.
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In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 18:19, s. 3749-57
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous studies, and testosterone (P = 7.54 x 10(-15)), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 x 10(-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Ahn, Jiyoung
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Schumacher, Fred ...
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Berndt, Sonja I
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Pfeiffer, Ruth
-
Albanes, Demetri ...
-
Andriole, Gerald ...
-
show more...
-
Ardanaz, Eva
-
Boeing, Heiner
-
Bueno-de-Mesquit ...
-
Chanock, Stephen ...
-
Clavel-Chapelon, ...
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Diver, W Ryan
-
Feigelson, Heath ...
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Gaziano, J Micha ...
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Giovannucci, Edw ...
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Haiman, Christop ...
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Henderson, Brian ...
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Hoover, Robert N
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Kolonel, Laurenc ...
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Kraft, Peter
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Ma, Jing
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Le Marchand, Loï ...
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Overvad, Kim
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Palli, Domenico
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Stattin, Pär
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Stampfer, Meir
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Stram, Daniel O
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Thomas, Gilles
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Thun, Michael J
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Travis, Ruth C
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Trichopoulos, Di ...
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Virtamo, Jarmo
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Weinstein, Steph ...
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Yeager, Meredith
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Kaaks, Rudolf
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Hunter, David J
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Hayes, Richard B
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show less...
- Articles in the publication
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Human molecular ...
- By the university
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Umeå University