SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wennberg Patrik) "

Sökning: WFRF:(Wennberg Patrik)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Araghi, M, et al. (författare)
  • No association between moist oral snuff (snus) use and oral cancer : pooled analysis of nine prospective observational studies
  • ????
  • Ingår i: Scandinavian Journal of Public Health. - SAGE Publications. - 1403-4948.
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: Worldwide, smokeless-tobacco use is a major risk factor for oral cancer. Evidence regarding the particular association between Swedish snus use and oral cancer is, however, less clear. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between snus use and oral cancer. Methods: A total of 418,369 male participants from nine cohort studies were followed up for oral cancer incidence through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. Results: During 9,201,647 person-years of observation, 628 men developed oral cancer. Compared to never-snus use, ever-snus use was not associated with oral cancer (adjusted HR 0.90, 95% CI: 0.74, 1.09). There were no clear trends in risk with duration or intensity of snus use, although lower intensity use (⩽ 4 cans/week) was associated with a reduced risk (HR 0.65, 95% CI: 0.45, 0.94). Snus use was not associated with oral cancer among never smokers (HR 0.87, 95% CI: 0.57, 1.32). Conclusions: Swedish snus use does not appear to be implicated in the development of oral cancer in men.
  •  
2.
  • Araghi, Marzieh, et al. (författare)
  • Smokeless tobacco (snus) use and colorectal cancer incidence and survival : Results from nine pooled cohorts
  • 2017
  • Ingår i: Scandinavian Journal of Public Health. - SAGE Publications. - 1403-4948. ; 45:8, s. 741-748
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: Although smoking is considered to be an established risk factor for colorectal cancer, the current evidence on the association between smokeless tobacco and colorectal cancer is scant and inconclusive. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess this association. Methods: A total of 417,872 male participants from nine cohort studies across Sweden were followed up for incidence of colorectal cancer and death. Outcomes were ascertained through linkage to health registers. We used shared frailty models with random effects at the study level to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During 7,135,504 person-years of observation, 4170 men developed colorectal cancer. There was no clear association between snus use and colorectal cancer overall. Exclusive current snus users, however, had an increased risk of rectal cancer (HR 1.40: 95% CI 1.09, 1.79). There were no statistically significant associations between snus use and either all-cause or colorectal cancer-specific mortality after colorectal cancer diagnosis. Conclusions: Our findings, from a large sample, do not support any strong relationships between snus use and colorectal cancer risk and survival among men. However, the observed increased risk of rectal cancer is noteworthy, and in merit of further attention.
  •  
3.
  • Araghi, Marzieh, et al. (författare)
  • Use of moist oral snuff (snus) and pancreatic cancer : Pooled analysis of nine prospective observational studies
  • 2017
  • Ingår i: International Journal of Cancer. - John Wiley and Sons Inc.. - 0020-7136. ; 141:1, s. 687-693
  • Tidskriftsartikel (refereegranskat)abstract
    • While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. During 9,276,054 person-years of observation, 1,447 men developed pancreatic cancer. Compared to never-snus use, current snus use was not associated with risk of pancreatic cancer (HR 0.96, 95% CI 0.83-1.11) after adjustment for smoking. Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer.
  •  
4.
  • Byhamre, Marja Lisa, et al. (författare)
  • Snus use during the life-course and risk of the metabolic syndrome and its components
  • 2017
  • Ingår i: Scandinavian Journal of Public Health. - Sage Publications. - 1403-4948 .- 1651-1905. ; 45:8, s. 733-740
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Objective: We aimed to investigate the association between life-course exposure to snus and prevalence of the metabolic syndrome and its components in adulthood.</p><p>Design and method: Tobacco habits at baseline (age 16) and three follow-ups (ages 21, 30 and 43) were assessed among 880 participants in a population-based cohort in Northern Sweden. Presence of the metabolic syndrome at age 43 was ascertained using the International Diabetes Federation criteria. Odds ratios and CIs for risk of the metabolic syndrome and its components by snus use at 16, 21, 30 and 43 years were calculated using logistic regression. Cumulative snus use was defined as number of life periods (1-4) with current snus use.</p><p>Results: At age 43, 164 participants (18.6%) were current snus users. We found no association between exclusive snus use at the ages of 16, 21, 30 and 43 years and the metabolic syndrome at age 43 years. Snus use (among non-smokers) was associated with raised triglycerides and high blood pressure in crude analysis, but not in multivariable models. There was no association between cumulative snus use and risk of the metabolic syndrome. Cumulative snus use was associated with central obesity, raised triglycerides and impaired fasting glucose/diabetes mellitus type 2 in crude analyses, but not after adjustments.</p><p>Conclusion: The health consequences of snus exposure from adolescence to mid-adulthood do not seem to include increased risk of the metabolic syndrome or its components. The cardio-metabolic risk of dual exposure to snus and cigarettes may warrant further attention.</p>
  •  
5.
  • Byhamre, Marja Lisa, et al. (författare)
  • Snus use during the life-course and risk of the metabolic syndrome and its components
  • 2017
  • Ingår i: Scandinavian Journal of Public Health. - SAGE PUBLICATIONS LTD. - 1403-4948 .- 1651-1905. ; 45:8, s. 733-740
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Objective: We aimed to investigate the association between life-course exposure to snus and prevalence of the metabolic syndrome and its components in adulthood.</p><p>Design and method: Tobacco habits at baseline (age 16) and three follow-ups (ages 21, 30 and 43) were assessed among 880 participants in a population-based cohort in Northern Sweden. Presence of the metabolic syndrome at age 43 was ascertained using the International Diabetes Federation criteria. Odds ratios and CIs for risk of the metabolic syndrome and its components by snus use at 16, 21, 30 and 43 years were calculated using logistic regression. Cumulative snus use was defined as number of life periods (1-4) with current snus use.</p><p>Results: At age 43, 164 participants (18.6%) were current snus users. We found no association between exclusive snus use at the ages of 16, 21, 30 and 43 years and the metabolic syndrome at age 43 years. Snus use (among non-smokers) was associated with raised triglycerides and high blood pressure in crude analysis, but not in multivariable models. There was no association between cumulative snus use and risk of the metabolic syndrome. Cumulative snus use was associated with central obesity, raised triglycerides and impaired fasting glucose/diabetes mellitus type 2 in crude analyses, but not after adjustments.</p><p>Conclusions: The health consequences of snus exposure from adolescence to mid-adulthood do not seem to include increased risk of the metabolic syndrome or its components. The cardio-metabolic risk of dual exposure to snus and cigarettes may warrant further attention.</p>
  •  
6.
  • Dam, Veerle, et al. (författare)
  • Association of menopausal characteristics and risk of coronary heart disease : : A pan-European case-cohort analysis
  • 2019
  • Ingår i: International Journal of Epidemiology. - Oxford University Press. - 0300-5771. ; 48:4, s. 1275-1285
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Earlier age at menopause has been associated with increased risk of coronary heart disease (CHD), but the shape of association and role of established cardiovascular risk factors remain unclear. Therefore, we examined the associations between menopausal characteristics and CHD risk; the shape of the association between age at menopause and CHD risk; and the extent to which these associations are explained by established cardiovascular risk factors. Methods: We used data from EPIC-CVD, a case-cohort study, which includes data from 23 centres from 10 European countries. We included only women, of whom 10 880 comprise the randomly selected sub-cohort, supplemented with 4522 cases outside the sub-cohort. We conducted Prentice-weighted Cox proportional hazards regressions with age as the underlying time scale, stratified by country and adjusted for relevant confounders. Results: After confounder and intermediate adjustment, post-menopausal women were not at higher CHD risk compared with pre-menopausal women. Among post-menopausal women, earlier menopause was linearly associated with higher CHD risk [HRconfounder and intermediate adjusted per-year decrease = 1.02, 95% confidence interval (CI) = 1.01-1.03, p = 0.001]. Women with a surgical menopause were at higher risk of CHD compared with those with natural menopause (HRconfounder-adjusted = 1.25, 95% CI = 1.10-1.42, p < 0.001), but this attenuated after additional adjustment for age at menopause and intermediates (HR = 1.12, 95% CI = 0.96-1.29, p = 0.15). A proportion of the association was explained by cardiovascular risk factors. Conclusions: Earlier and surgical menopause were associated with higher CHD risk. These associations could partially be explained by differences in conventional cardiovascular risk factors. These women might benefit from close monitoring of cardiovascular risk factors and disease.
7.
  • Gallo, Valentina, et al. (författare)
  • Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study.
  • 2016
  • Ingår i: European Journal of Epidemiology. - Springer. - 1573-7284.
  • Tidskriftsartikel (refereegranskat)abstract
    • Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42-1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased-not increased like in case-control studies-risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.
  •  
8.
  • Kilpelainen, Tuomas O., et al. (författare)
  • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
  • 2019
  • Ingår i: Nature Communications. - London : Nature Publishing Group. - 2041-1723 .- 2041-1723. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol- increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.</p>
9.
  • Lassale, Camille, et al. (författare)
  • Separate and combined associations of obesity and metabolic health with coronary heart disease : A pan-European case-cohort analysis
  • 2018
  • Ingår i: European Heart Journal. - Oxford University Press. - 0195-668X. ; 39:5, s. 397-406
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: The hypothesis of 'metabolically healthy obesity' implies that, in the absence of metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular risk We tested this hypothesis in a large pan-European prospective study. Methods and results: We conducted a case-cohort analysis in the 520 000-person European Prospective Investigation into Cancer and Nutrition study ('EPIC-CVD'). During a median follow-up of 12.2 years, we recorded 7637 incident coronary heart disease (CHD) cases. Using cut-offs recommended by guidelines, we defined obesity and overweight using body mass index (BMI), and metabolic dysfunction ('unhealthy') as ≥3 of elevated blood pressure, hypertriglyceridaemia, low HDL-cholesterol, hyperglycaemia, and elevated waist circumference. We calculated hazard ratios (HRs) and 95% confidence intervals (95% CI) within each country using Prentice-weighted Cox proportional hazard regressions, accounting for age, sex, centre, education, smoking, diet, and physical activity. Compared with metabolically healthy normal weight people (reference), HRs were 2.15 (95% CI: 1.79; 2.57) for unhealthy normal weight, 2.33 (1.97; 2.76) for unhealthy overweight, and 2.54 (2.21; 2.92) for unhealthy obese people. Compared with the reference group, HRs were 1.26 (1.14; 1.40) and 1.28 (1.03; 1.58) for metabolically healthy overweight and obese people, respectively. These results were robust to various sensitivity analyses. Conclusion: Irrespective of BMI, metabolically unhealthy individuals had higher CHD risk than their healthy counterparts. Conversely, irrespective of metabolic health, overweight and obese people had higher CHD risk than lean people. These findings challenge the concept of 'metabolically healthy obesity', encouraging population-wide strategies to tackle obesity.
  •  
10.
  • Peters, Sanne A E, et al. (författare)
  • Parity, breastfeeding and risk of coronary heart disease : A pan-European case-cohort study
  • 2016
  • Ingår i: European Journal of Preventive Cardiology. - SAGE Publications. - 2047-4873. ; 23:16, s. 1755-1765
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity and breastfeeding practices with the incidence of CHD later in life among women in a large, pan-European cohort study. Methods Data were used from European Prospective Investigation into Cancer and Nutrition (EPIC)-CVD, a case-cohort study nested within the EPIC prospective study of 520,000 participants from 10 countries. Information on reproductive history was available for 14,917 women, including 5138 incident cases of CHD. Using Prentice-weighted Cox regression separately for each country followed by a random-effects meta-analysis, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD, after adjustment for age, study centre and several socioeconomic and biological risk factors. Results Compared with nulliparous women, the adjusted HR was 1.19 (95% CI: 1.01-1.41) among parous women; HRs were higher among women with more children (e.g., adjusted HR: 1.95 (95% CI: 1.19-3.20) for women with five or more children). Compared with women who did not breastfeed, the adjusted HR was 0.71 (95% CI: 0.52-0.98) among women who breastfed. For childbearing women who never breastfed, the adjusted HR was 1.58 (95% CI: 1.09-2.30) compared with nulliparous women, whereas for childbearing women who breastfed, the adjusted HR was 1.19 (95% CI: 0.99-1.43). Conclusion Having more children was associated with a higher risk of CHD later in life, whereas breastfeeding was associated with a lower CHD risk. Women who both had children and breastfed did have a non-significantly higher risk of CHD.
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (33)
Typ av publikation
tidskriftsartikel (106)
annan publikation (5)
konferensbidrag (4)
doktorsavhandling (3)
forskningsöversikt (2)
licentiatavhandling (2)
visa fler...
rapport (1)
visa färre...
Typ av innehåll
refereegranskat (105)
övrigt vetenskapligt (25)
populärvet., debatt m.m. (1)
Författare/redaktör
Wennberg, Patrik, (92)
Wennberg, Patrik, 19 ... (25)
Danesh, John (23)
Boeing, Heiner (20)
Pedersen, Nancy L (19)
Kaaks, Rudolf (18)
visa fler...
Norberg, Margareta, (18)
Di Angelantonio, Ema ... (18)
Tumino, Rosario (17)
Jansson, Jan Håkan, (17)
Overvad, Kim (15)
Riboli, Elio (15)
Weiderpass, Elisabet ... (15)
Rosengren, Annika (15)
Trichopoulou, Antoni ... (14)
Khaw, Kay-Tee (13)
Engström, Gunnar, (13)
Panico, Salvatore (13)
Wareham, Nicholas J (13)
Gallacher, John (13)
Kaptoge, Stephen (13)
Rolandsson, Olov, (12)
Gudnason, Vilmundur (12)
Gillum, Richard F. (12)
Johansson, Ingegerd, (12)
Hammarström, Anne, (12)
Ridker, Paul M., (12)
Kauhanen, Jussi, (12)
Nordestgaard, Borge ... (11)
Lager, Anton (11)
Wennberg, P. (11)
Alfredsson, Lars (11)
Magnusson, Cecilia (11)
Bellocco, Rino (11)
Lundberg, Michael (11)
van der Schouw, Yvon ... (11)
Woodward, Mark (11)
Salonen, Jukka T. (11)
Wood, Angela M., (11)
Onat, Altan (11)
Sacerdote, Carlotta (10)
Tjønneland, Anne (10)
Key, Timothy J (10)
Psaty, Bruce M. (10)
Wennberg, Maria, (10)
Lagerros, Ylva Troll ... (10)
Kuller, Lewis H. (10)
Araghi, Marzieh (10)
Panagiotakos, Demost ... (10)
Arriola, Larraitz, (10)
visa färre...
Lärosäte
Umeå universitet (75)
Lunds universitet (18)
Uppsala universitet (13)
Karolinska Institutet (11)
Göteborgs universitet (8)
Mittuniversitetet (3)
visa fler...
Stockholms universitet (2)
Örebro universitet (2)
Linnéuniversitetet (2)
Kungliga Tekniska Högskolan (1)
Linköpings universitet (1)
Naturvårdsverket (1)
Högskolan i Gävle (1)
Blekinge Tekniska Högskola (1)
visa färre...
Språk
Engelska (113)
Svenska (5)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (111)
Naturvetenskap (4)
Samhällsvetenskap (4)
Teknik (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy