| 1. |
- Chrcanovic, Bruno, et al.
(författare)
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Bruxism and dental implant treatment complications: a retrospective comparative study of 98 bruxer patients and a matched group.
- 2017
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Ingår i: Clinical oral implants research. - : Wiley. - 1600-0501 .- 0905-7161. ; 28:7
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Tidskriftsartikel (refereegranskat)abstract
- Objectives To analyze the complications of dental implant treatment in a group of patients with bruxism in comparison with a matched group of non‐bruxers. Material and methods Patients being diagnosed as bruxers were identified within a group of patients consecutively treated with implant‐supported prostheses at one specialist clinic, based on the most recent listed sign and symptoms of bruxism according to the International Classification of Sleep Disorders. A diagnostic grading system of “possible,” “probable,” and “definite” sleep or awake bruxism was used, according to a recent published international consensus. A case–control matching model was used to match the bruxers with a group of non‐bruxers, based on five variables. Implant‐, prosthetic‐, and patient‐related data were collected, as well as 14 mechanical complications, and compared between groups. Results Ninety‐eight of 2670 patients were identified as bruxers. The odds ratio of implant failure in bruxers in relation to non‐bruxers was 2.71 (95% CI 1.25, 5.88). Considering the same number of patients with the same total number of implants equally distributed between groups, the bruxers group had a higher prevalence of mechanical complications in comparison with the non‐bruxers group. Conclusions This study suggests that bruxism may significantly increase both the implant failure rate and the rate of mechanical and technical complications of implant‐supported restorations. Other risk factors may also have influenced the results.
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| 2. |
- Chrcanovic, Bruno, et al.
(författare)
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Bruxism and Dental Implants: A Meta-Analysis.
- 2015
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Ingår i: Implant dentistry. - : Lippincott Williams & Wilkins. - 1538-2982 .- 1056-6163. ; 24:5, s. 505-516
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Tidskriftsartikel (refereegranskat)abstract
- To test the null hypothesis of no difference in the implant failure rates, postoperative infection, and marginal bone loss after the insertion of dental implants in bruxers compared with the insertion in non-bruxers against the alternative hypothesis of a difference.
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| 3. |
- Chrcanovic, Bruno, et al.
(författare)
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Dental implants inserted in male versus female patients: a systematic review and meta-analysis.
- 2015
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Ingår i: Journal of oral rehabilitation. - : Wiley. - 1365-2842 .- 0305-182X. ; 42:9, s. 709-722
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this meta-analysis was to test the null hypothesis of no difference in the failure rates, marginal bone loss (MBL) and post-operative infection for implants inserted in male or female patients, against the alternative hypothesis of a difference. An electronic search without time or language restrictions was undertaken in December 2014. Eligibility criteria included clinical human studies, either randomized or not. Ninety-one publications were included, with a total of 27203 implants inserted in men (1185 failures), and 25154 implants inserted in women (1039 failures). The results suggest that the insertion of dental implants in male patients statistically affected the implant failure rates (RR 1·21, 95% CI 1·07-1·37, P=0·002). Due to the limited number of studies reporting results on MBL, it is difficult to estimate the real effect of the insertion of implants in different sexes on the marginal bone level. Due to lack of satisfactory information, meta-analysis for the outcome 'post-operative infection' was not performed. The results have to be interpreted with caution due to the presence of several confounding factors in the included studies.
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| 4. |
- Chrcanovic, Bruno, et al.
(författare)
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Factors Influencing Early Dental Implant Failures
- 2016
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Ingår i: Journal of Dental Research. - : SAGE Publications. - 0022-0345 .- 1544-0591. ; 95:9, s. 995-1002
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the present study was to assess the influence of local and systemic factors on the occurrence of dental implant failures up to the second-stage surgery (abutment connection). This retrospective study is based on 2,670 patients who received 10,096 implants and were consecutively treated with implant-supported prostheses between 1980 and 2014 at 1 specialist clinic. Several anatomic-, patient-, health-, and implant-related factors were collected. Descriptive statistics were used to describe the patients and implants. Univariate and multivariate logistic regression models were used at the patient level as well as the implant level to evaluate the effect of explanatory variables on the failure of implants up to abutment connection. A generalized estimating equation method was used for the implant-level analysis to account for the fact that repeated observations (several implants) were available for a single patient. Overall, 642 implants (6.36%) failed, of which 176 (1.74%) in 139 patients were lost up to second-stage surgery. The distribution of implants in sites of different bone quantities and qualities was quite similar between implants lost up to and after abutment connection. Smoking and the intake of antidepressants were the statistically significant predictors in the multivariate model (ClinicalTrials. gov NCT02369562).
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| 5. |
- Chrcanovic, Bruno, et al.
(författare)
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Immediately loaded non-submerged versus delayed loaded submerged dental implants: A meta-analysis.
- 2015
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Ingår i: International Journal of Oral & Maxillofacial Surgery. - : Elsevier BV. - 0901-5027 .- 1399-0020. ; 44:4, s. 493-506
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the present meta-analysis was to test the null hypothesis of no difference in the implant failure rate, postoperative infection, and marginal bone loss for patients being rehabilitated with immediately loaded non-submerged dental implants or delayed loaded submerged implants, against the alternative hypothesis of a difference. An electronic search without time or language restrictions was undertaken in March 2014. Eligibility criteria included clinical human studies, either randomized or not. The search strategy resulted in 28 publications. The inverse variance method was used for a random- or fixed-effects model, depending on the heterogeneity. The estimates of an intervention were expressed as the risk ratio (RR) and mean difference (MD) in millimetres. Twenty-three studies were judged to be at high risk of bias, one at moderate risk of bias, and four studies were considered at low risk of bias. The difference between procedures (submerged vs. non-submerged implants) significantly affected the implant failure rate (P=0.02), with a RR of 1.78 (95% confidence interval (CI) 1.12-2.83). There was no apparent significant effect of non-submerged dental implants on the occurrence of postoperative infection (P=0.29; RR 2.13, CI 0.52-8.65) or on marginal bone loss (P=0.77; MD -0.03, 95% CI -0.23 to 0.17).
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| 6. |
- Chrcanovic, Bruno, et al.
(författare)
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Platform switch and dental implants: A meta-analysis.
- 2015
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Ingår i: Journal of dentistry. - : Elsevier BV. - 1879-176X .- 0300-5712. ; 43:6, s. 629-646
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Tidskriftsartikel (refereegranskat)abstract
- To test the null hypothesis of no difference in the implant failure rates, marginal bone loss (MBL) and postoperative infection in patients who received platform-switched implants or platform-matched implants, against the alternative hypothesis of a difference.
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| 7. |
- Trindade, Ricardo, et al.
(författare)
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Osseointegration and foreign body reaction: Titanium implants activate the immune system and suppress bone resorption during the first 4 weeks after implantation
- 2018
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Ingår i: Clinical Implant Dentistry and Related Research. - : Wiley. - 1523-0899 .- 1708-8208. ; 20:1, s. 82-91
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Tidskriftsartikel (refereegranskat)abstract
- © 2017 Wiley Periodicals, Inc. Background: Osseointegration mechanisms are still not entirely understood. Purpose: The present pilot study aims at demonstrating the involvement of the immune system in the process of osseointegration around titanium implants, comparing bone healing in the presence and absence of a titanium implant. Materials and Methods: Fifteen New Zealand White rabbits had one osteotomy performed at each of the distal femurs; on one side, no implant was placed (sham) and on the other side a titanium implant was introduced. Subjects were sacrificed at 10 and 28 days for gene expression analysis (three subjects each time point) and for decalcified qualitative histology (six subjects each time point). At 10 days, the three subjects for gene expression analysis were part of the six subjects for histology. Results: Gene expression analysis: at 10 days, ARG1 was significantly up-regulated around titanium, indicating an activation of M2-macrophages. At 28 days CD11b, ARG1, NCF-1, and C5aR1 were significantly up-regulated, indicating activation of the innate immune system, respectively M1-macrophages, M2-macrophages and group 2-innate lymphoid cells, neutrophils, and the complement system; on the other hand, the bone resorption markers RANKL, OPG, cathepsin K, and TRAP were significantly down-regulated around titanium. Histology: at 10 days new bone formation is seen around both sham and titanium sites, separating bone marrow from the osteotomy/implant site; at 28 days no bone trabeculae is seen on the sham site, which is healing at the original cortical level, whereas around titanium implants, bone continues into organization of more mature cortical-like bone, forming a layer between the implant and the bone marrow. Conclusions: The presence of a titanium implant during bone healing activates the immune system and displays type 2 inflammation, which is likely to guide the host-biomaterial relationship. At the same time, bone resorption is suppressed around titanium sites compared to sham sites after 4 weeks of implantation, suggesting a shift to a more pronounced bone forming environment. This suggests two important steps in osseointegration: identification of the titanium foreign body by the immune system and the development of a bone forming environment, that at tissue level translates into bone build-up on the titanium surface and can be perceived as an attempt to isolate the foreign body from the bone marrow space.
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