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1.	Jimbo, Ryo, 1979, et al. (author) Histological and three-dimensional evaluation of osseointegration to nanostructured calcium phosphate-coated implants. 2011 In: Acta biomaterialia. - : Elsevier BV. - 1878-7568 .- 1742-7061. Journal article (peer-reviewed)abstract Nanostructures on implant surfaces have been shown to enhance osseointegration; however, commonly used evaluation techniques are probably not sufficiently sensitive to fully determine the effects of this process. This study aimed to observe the osseointegration properties of nanostructured calcium phosphate (CaP)-coated implants, by using a combination of three-dimensional imaging and conventional histology. Titanium implants were coated with stable CaP nanoparticles using an immersion technique followed by heat treatment. Uncoated implants were used as the control. After topographical and chemical characterizations, implants were inserted into the rabbit femur. After 2 and 4weeks, the samples were retrieved for micro-computed tomography and histomorphometric evaluation. Scanning electron microscopy evaluation indicated that the implant surface was modified at the nanoscale by CaP to obtain surface textured with rod-shaped structures. Relative to the control, the bone-to-implant contact for the CaP-coated implant was significantly higher at 4weeks after the implant surgery. Further, corresponding 3-D images showed active bone formation surrounding the implant. 3-D quantification and 2-D histology demonstrated statistical correlation; moreover, 3-D quantification indicated a statistical decrease in bone density in the non-coated control implant group between 2 and 4weeks after the surgery. The application of 3-D evaluation further clarified the temporal characteristics and biological reaction of implants in bone.
2.	Rosa, Marcio Borges, et al. (author) Micrometric characterization of the implant surfaces from the five largest companies in Brazil, the second largest worldwide implant market. 2013 In: The International journal of oral & maxillofacial implants. - : Quintessence Publishing. - 1942-4434 .- 0882-2786. ; 28:2, s. 358-65 Journal article (peer-reviewed)abstract To characterize the surface of implants from Brazilian companies by light interferometry and evaluate the level of control of the surface treatment process.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Wennerberg, Ann, 195 ... (2); Albrektsson, Tomas, ... (1); Jimbo, Ryo, 1979 (1); Andersson, Martin, 1 ... (1); Coelho, Paulo G. (1); Vandeweghe, Stefan (1); show more...; Hayashi, Mariko (1); Schwartz-Filho, Humb ... (1); Ono, Daisuke (1); Rosa, Marcio Borges (1); Francischone, Carlos ... (1); Filho, Humberto Osva ... (1); show less...

University: University of Gothenburg (2); Malmö University (2); Chalmers University of Technology (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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