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Correlation between Genetic and Geographic Structure in Europe

Lao, O. (författare)
Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands
Lu, T.T. (författare)
Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany
Nothnagel, M. (författare)
Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany
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Junge, O. (författare)
Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany
Freitag-Wolf, S. (författare)
Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany
Caliebe, A. (författare)
Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany
Balascakova, M. (författare)
Institute of Biology and Medical Genetics, University Hospital Motol, 2nd School of Medicine, CZ 150 06 Prague 5, Czech Republic
Bertranpetit, J. (författare)
Unitat de Biologia Evolutiva, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain
Bindoff, L.A. (författare)
Department of Neurology, Haukeland University Hospital, Institute of Clinical Medicine, 5021 Bergen, Norway
Comas, D. (författare)
Unitat de Biologia Evolutiva, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain
Holmlund, Gunilla (författare)
Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,National Board of Forensic Medicine, Linköping, Sweden
Kouvatsi, A. (författare)
Department of Genetics, Development, and Molecular Biology, Aristotle University of Thessaloniki, GR-540 06 Thessaloniki, Greece
Macek, M. (författare)
Institute of Biology and Medical Genetics, University Hospital Motol, 2nd School of Medicine, CZ 150 06 Prague 5, Czech Republic
Mollet, I. (författare)
Laboratoire d'Empreintes Génétiques, EFS-RA site de Lyon, 69007 Lyon, France
Parson, W. (författare)
Institute of Legal Medicine, Medical University Innsbruck, A-6020 Innsbruck, Austria
Palo, J. (författare)
Department of Forensic Medicine, University of Helsinki, Helsinki, FIN-00014, Finland
Ploski, R. (författare)
Department of Medical Genetics, Medical University Warsaw, 02-007 Warsaw, Poland
Sajantila, A. (författare)
Department of Forensic Medicine, University of Helsinki, Helsinki, FIN-00014, Finland
Tagliabracci, A. (författare)
Istituto di Medicina Legale, University of Ancona, I-60020 Ancona, Italy
Gether, U. (författare)
Molecular Neuropharmacology Group, Center for Pharmacogenomics Department of Neuroscience and Pharmacology, University of Copenhagen, 2200 Copenhagen, Denmark
Werge, T. (författare)
Research Institute of Biological Psychiatry, Center for Pharmacogenomics, Mental Health Center Sct. Hans, DK-4000 Roskilde, Denmark
Rivadeneira, F. (författare)
Department of Internal Medicine, Genetics Laboratory, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands, Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands
Hofman, A. (författare)
Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands
Uitterlinden, A.G. (författare)
Department of Internal Medicine, Genetics Laboratory, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands, Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands
Gieger, C. (författare)
Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians University, D-81377 Munich, Germany
Wichmann, H.-E. (författare)
Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians University, D-81377 Munich, Germany
Ruther, A. (författare)
Rüther, A., Institut für Medizinische Molekularbiologie, Christian-Albrechts University Kiel, D-24105 Kiel, Germany
Schreiber, S. (författare)
Institut für Medizinische Molekularbiologie, Christian-Albrechts University Kiel, D-24105 Kiel, Germany
Becker, C. (författare)
Cologne Center for Genomics, Institut für Genetik, University of Cologne, D-50674 Cologne, Germany
Nurnberg, P. (författare)
Nürnberg, P., Cologne Center for Genomics, Institut für Genetik, University of Cologne, D-50674 Cologne, Germany
Nelson, M.R. (författare)
Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, United States
Krawczak, M. (författare)
Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany
Kayser, M. (författare)
Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands
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 (creator_code:org_t)
Elsevier BV, 2008
2008
Engelska.
Ingår i: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 18:16, s. 1241-1248
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Understanding the genetic structure of the European population is important, not only from a historical perspective, but also for the appropriate design and interpretation of genetic epidemiological studies. Previous population genetic analyses with autosomal markers in Europe either had a wide geographic but narrow genomic coverage [1, 2], or vice versa [3-6]. We therefore investigated Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations, widely spread over Europe. Although we found only a low level of genetic differentiation between subpopulations, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance. Furthermore, mean heterozygosity was larger, and mean linkage disequilibrium smaller, in southern as compared to northern Europe. Both parameters clearly showed a clinal distribution that provided evidence for a spatial continuity of genetic diversity in Europe. Our comprehensive genetic data are thus compatible with expectations based upon European population history, including the hypotheses of a south-north expansion and/or a larger effective population size in southern than in northern Europe. By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry. © 2008 Elsevier Ltd. All rights reserved.

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EVOL_ECOL
HUM_DISEASE
NATURAL SCIENCES
NATURVETENSKAP
MEDICINE
MEDICIN

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