| 1. |
- Alexander, Stephen P. H., et al.
(författare)
-
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- 2023
-
Ingår i: BRITISH JOURNAL OF PHARMACOLOGY. - : British pharmacological society. - 0007-1188 .- 1476-5381. ; 180, s. S23-S144
-
Tidskriftsartikel (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
|
|
| 2. |
- Christopoulos, Arthur, et al.
(författare)
-
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.
- 2021
-
Ingår i: British journal of pharmacology. - : Wiley. - 1476-5381 .- 0007-1188. ; 178 Suppl 1, s. S27-S156
-
Forskningsöversikt (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
|
|
| 3. |
- Kettil, Gustav, 1990, et al.
(författare)
-
A Multiscale Method for Discrete Fiber Network Models
- 2018
-
Ingår i: 6th European Conference on Computational Mechanics (Solids, Structures and Coupled Problems). 7th European Conference on Computational Fluid Dynamics, 11-15 June 2018, Glasgow, UK.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The mechanics of paper depends on the properties of its fibers and bonds. Modeling paper as a network [1] will include effects of single fibers and bonds, capturing heterogeneous properties. In the ISOP (Innovative Simulation of Paper) project at Fraunhofer-Chalmers Centre, the forming process is simulated [2, 3]. To investigate the mechanical properties of the resulting simulated paper sheets a network approach is utilized. Numerical investigation of fiber networks is demanding due to the large number of fibers and bonds, fluctuation of their properties, and the non-regular network structure. Multiscale methods are useful tools to circumvent such problems. In this work a multi-scale approach for fiber networks is developed, based on a FEM-method for continua [4]. Consider a fiber network governed by a model resulting in an equation Kx = F, where K describes the network properties, x are node displacements, and F are applied forces. The idea of the multi-scale method is to consider a subset of all nodes, denoted coarse nodes, which in turn represents a coarse grid. At each coarse node a basis function is defined similarly as in the finite element method. By solving a system including the coarse nodes an approximation would be attained, however this approximation would leave out the fine scale effects of the heterogeneous network. Instead the coarse basis functions are modified by solving a local system at each coarse node, including surrounding fine nodes. These modified basis functions are thereafter used when solving the global system, resulting in an approximation of the network displacements now including effects from the fine scale.
|
|
| 4. |
- Kettil, Gustav, 1990, et al.
(författare)
-
Detailed Simulations of Early Paper Forming
- 2015
-
Ingår i: COST FP1005 Fibre Suspension Flow Modelling Final Conference Trondheim 2015 June 9-11.
-
Konferensbidrag (refereegranskat)abstract
- Computer simulations are important to increase the knowledge of the processes involved in paper making. Because of the complexity of the paper processes the development of simulation tools requires models and numerical methods which capture as much as possible of the real physical phenomena. In this paper a framework for simulation of fiber suspension flow is presented. The framework is founded on a fluid solver for the Navier-Stokes equations and a fiber model based on finite strain beam theory including shearing. Moreover, the coupling between fibers and fluid is resolved with the immersed boundary method and the interaction between the fibers is calculated using a model based on DLVO-theory.
|
|
| 5. |
- Kettil, Gustav, 1990, et al.
(författare)
-
Novel Contact Forces for Immersed Boundary Paper Forming Simulations
- 2015
-
Ingår i: Online proceedings: http://tappi.sclivelearningcenter.com/; PF2 - The Past, Present and Future of CFD Papermaking; PaperCon 2015 Atlanta April 19-22.
-
Konferensbidrag (refereegranskat)abstract
- To be able to simulate the different processes involved in paper machines, models, numerical methods and algorithms have to be developed which capture as much as possible of the real physical phenomena. In this paper a model for calculation of the chemical and physical interaction between objects included in a fiber suspension is presented. The contact force model is based on DLVO theory [1, 2] and uses so-called contact points distributed along the fiber suspension objects. The contact model has been used in an existing framework to simulate the build-up of low density paper webs. In the framework fibers are modeled as elliptical cylinders whose movements are described by finite-strain beam theory which includes shearing. The fluid flow is computed using a Navier-Stokes solver and immersed boundary methods are utilized to resolve the flow around each fiber. For validation, the air permeability and thickness of the paper webs have been measured and compared with simulated data. The result demonstrates that the software can be used to simulate paper forming.
|
|
| 6. |
- Kettil, Gustav, et al.
(författare)
-
Numerical upscaling of discrete network models
- 2020
-
Ingår i: BIT (Copenhagen). - : Springer Science and Business Media LLC. - 0006-3835 .- 1572-9125. ; 60:1, s. 67-92
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper a numerical multiscale method for discrete networks is presented. The method gives an accurate coarse scale representation of the full network by solving sub-network problems. The method is used to solve problems with highly varying connectivity or random network structure, showing optimal order convergence rates with respect to the mesh size of the coarse representation. Moreover, a network model for paper-based materials is presented. The numerical multiscale method is applied to solve problems governed by the presented network model.
|
|
