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Träfflista för sökning "WFRF:(Westerlund Anna 1978 ) ;pers:(Reymer Anna 1983)"

Sökning: WFRF:(Westerlund Anna 1978 ) > Reymer Anna 1983

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1.
  • Nordell, Pär, 1978, et al. (författare)
  • DNA Polymorphism as an Origin of Adenine-Thymine Tract Length-Dependent Threading Intercalation Rate
  • 2008
  • Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 130:44, s. 14651-14658
  • Tidskriftsartikel (refereegranskat)abstract
    • Binuclear ruthenium complexes that bind DNA by threading intercalation have recently been found to exhibit an exceptional kinetic selectivity for long polymeric adenine-thymine (AT) DNA. A series of oligonucleotide hairpin duplexes containing a central tract of 6-44 alternating AT base pairs have here been used to investigate the nature of the recognition mechanism. We find that, above a threshold AT tract length corresponding to one helix turn of B-DNA, a dramatic increase in threading intercalation rate occurs. In contrast, such length dependence is not observed for rates of unthreading. Intercalation by any mechanism that depends on the open end of the hairpin was found not to be important in the series of oligonucleotides used, as verified by including in the study a hairpin duplex cyclized by a copper-catalyzed "click" reaction. Our observations are interpreted in terms of a conformational pre-equilibrium, determined by the length of the AT tract. We finally find that mismatches or loops in the oligonucleotide facilitate the threading process, of interest for the development of mismatch-recognizing probes. © 2008 American Chemical Society.
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2.
  • Nordell, Pär, 1978, et al. (författare)
  • Finding at-DNA--kinetic recognition of long adenine-thymine stretches by metal-ligand complexes.
  • 2008
  • Ingår i: Nucleic acids symposium series (2004). - 1746-8272. ; :52, s. 131-132
  • Tidskriftsartikel (refereegranskat)abstract
    • High selectivity for long AT sequences can be attained by kinetically controlled DNA threading intercalation by binuclear ruthenium(II) complexes. The rate of intercalation is strongly correlated to the number of consecutive AT basepairs, being up to 2500 times faster with an AT polymer compared to mixed-sequence DNA.
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  • Resultat 1-2 av 2
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tidskriftsartikel (2)
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refereegranskat (2)
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Nordén, Bengt, 1945 (2)
Westerlund, Fredrik, ... (2)
Lincoln, Per, 1958 (2)
Nordell, Pär, 1978 (2)
Reymer, Anna, 19... (2)Ta bort avgränsningen
Brown, T. (1)
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El-Sagheer, Afaf (1)
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Chalmers tekniska högskola (2)
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2008 (2)

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