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1.	Morgan, AR, et al. (author) Inflammatory biomarkers in Alzheimer's disease plasma 2019 In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 15:6, s. 776-787 Journal article (peer-reviewed)
2.	Bos, I., et al. (author) Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum 2019 In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 15:5, s. 644-654 Journal article (peer-reviewed)abstract Introduction: We investigated relations between amyloid-beta (A beta) status, apolipoprotein E (APOE) e4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau). Methods: We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with A beta status (Ab beta- vs. A beta+), clinical diagnosis APOE epsilon 4 carriership, baseline cognition, and change in cognition. Results: Ng and T-tau distinguished between A beta+ from A beta- individuals in each clinical group, whereas NFL and YKL-40 were associated with A beta+ in nondemented individuals only. APOE epsilon 4 carriership did not influence NFL, Ng, and YKL-40 in A beta+ individuals. NFL was the best predictor of cognitive decline in A beta+ individuals across the cognitive spectrum. Discussion: Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Vandenberghe, R (2); Zetterberg, Henrik, ... (2); Lovestone, S (2); Tsolaki, M (2); Blin, O (2); Lleó, A. (2); show more...; Barkhof, F (2); Scheltens, P (2); Frolich, L (2); Engelborghs, S. (2); Blennow, Kaj, 1958 (1); Campbell, B. (1); Kemp, J. (1); Sutherland, M. (1); Cattaneo, A (1); Mancuso, R (1); Barker, GJ (1); Wahlund, LO (1); Wallin, Anders, 1950 (1); Eriksson, H (1); Kettunen, Petronella (1); Soininen, H (1); Isaac, J (1); Khan, S (1); Drevets, WC (1); Mecocci, P (1); Reynolds, R. (1); Smith, K. (1); Richardson, J (1); Jones, D (1); O'Connor, J (1); Jones, H (1); Molinuevo, JL (1); Visser, PJ (1); Richardson, JC (1); Bordet, R (1); Sala, I. (1); Patel, J (1); Andreasson, Ulf, 196 ... (1); Gastambide, F. (1); Vyas, A (1); Moller, T (1); Singh, N (1); Gee, A (1); Cash, D (1); Turkheimer, F (1); Turner, L (1); Verhey, F (1); Richardson, J.C. (1); Kolb, H. (1); show less...

University: University of Gothenburg (2); Karolinska Institutet (2); Örebro University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2019 (2)

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