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- Dahl, S., et al.
(författare)
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High prevalence of pituitary hormone deficiency in both unilateral and bilateral optic nerve hypoplasia
- 2019
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 108:9, s. 1677-1685
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Tidskriftsartikel (refereegranskat)abstract
- Aim This study examined the prevalence of neurological impairment and pituitary hormone deficiency (PHD) in patients with unilateral and bilateral optic nerve hypoplasia (ONH). Methods A population-based cross-sectional cohort study of 65 patients (51% female) with ONH was conducted in Stockholm. Of these were 35 bilateral and 30 unilateral. The patients were below 20 years of age, living in Stockholm in December 2009 and found through database searching. The median age at the analysis of the results in January 2018 was 16.1 years (range 8.1-27.5 years). Neurological assessments and blood sampling were conducted, neuroradiology was reviewed and growth curves were analysed. Diagnoses of PHDs were based on clinical and biochemical evidence of hormone deficiency. Results Neurological impairments were identified in 47% of the patients and impairments in gross and fine motor function were more prevalent in bilateral ONH (p < 0.001). In addition, 9% had cerebral palsy and 14% had epilepsy. The prevalence of PHD was 29 and 19% had multiple PHD. Conclusion Children with ONH had a high risk of neurological impairment, especially in bilateral disease. Both unilateral and bilateral ONH signified an increased prevalence of PHD and all these children should be endocrinologically followed up until completed puberty.
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| 2. |
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Ett bibliotek i takt med tiden : Linköpings universitetsbibliotek under 50 år
- 2022
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Konstnärligt arbeteabstract
- Utställningen Ett bibliotek i takt med tiden: Linköpings universitetsbibliotek under 50 år skildrade bibliotekets historia och biblioteksteknikens utveckling från 1970-talet till idag.Utställningen fokuserade på olika teman som varit signifikativa för Linköpings universitetsbibliotek, som etablerades 1969 som Linköpings högskolas bibliotek. Dessa teman var den så kallade Linköpingsmodellen och dess kvartersbibliotek, försöksverksamheten med bibliotekssystemet Libris i början av 1970-talet, de första databaserna för att söka vetenskapliga publikationer, högskolereformen 1977 och dess betydelse för universitetsbiblioteket, tillkomsten av Hälsouniversitetets bibliotek 1986, datoriseringen under 1980-talet, användarundervisningens utveckling, tillkomsten av det elektroniska förlaget LiU E-Press 1996, skapande av Campus Norrköpings bibliotek 1998, den tilltagande digitaliseringen under 2000-talet, bibliometrins ökande betydelse samt utvecklingen under 2010-talet med bland annat byte av klassifikationssystem, flyttar och sammanslagningar av bibliotek.
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| 3. |
- Forslin, Y., et al.
(författare)
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Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in Multiple Sclerosis
- 2019
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Ingår i: American Journal of Neuroradiology. - : AMER SOC NEURORADIOLOGY. - 0195-6108 .- 1936-959X. ; 40:8, s. 1265-1273
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: Brain gadolinium retention is consistently reported for linear gadolinium-based contrast agents, while the results for macrocyclics are contradictory and potential clinical manifestations remain controversial. Furthermore, most previous studies are based on conventional T1-weighted MR imaging. We therefore aimed to quantitatively investigate longitudinal and transversal relaxation in the brain in relation to previous gadolinium-based contrast agent administration and explore associations with disability in multiple sclerosis. MATERIALS AND METHODS: Eighty-five patients with MS and 21 healthy controls underwent longitudinal and transverse relaxation rate (R-1 and R-2) relaxometry. Patients were divided into linear, mixed, and macrocyclic groups based on previous gadolinium-based contrast agent administration. Neuropsychological testing was performed in 53 patients. The dentate nucleus, globus pallidus, caudate nucleus, and thalamus were manually segmented. Repeatability measures were also performed. RESULTS: The relaxometry was robust (2.0% scan-rescan difference) and detected higher R-1 (dentate nucleus, globus pallidus, caudate nucleus, thalamus) and R-2 (globus pallidus, caudate nucleus) in patients receiving linear gadolinium-based contrast agents compared with controls. The number of linear gadolinium-based contrast agent administrations was associated with higher R-1 and R-2 in all regions (except R-2 in the thalamus). No similar differences and associations were found for the macrocyclic group. Higher relaxation was associated with lower information-processing speed (dentate nucleus, thalamus) and verbal fluency (caudate nucleus, thalamus). No associations were found with physical disability or fatigue. CONCLUSIONS: Previous linear, but not macrocyclic, gadolinium-based contrast agent administration is associated with higher relaxation rates in a dose-dependent manner. Higher relaxation in some regions is associated with cognitive impairment but not physical disability or fatigue in MS. The findings should be interpreted with care but encourage studies into gadolinium retention and cognition.
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| 4. |
- Lundberg, Peter, et al.
(författare)
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Low-dose acetylsalicylic acid reduces local inflammation and tissue perfusion in dense breast tissue in postmenopausal women
- 2024
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Ingår i: Breast Cancer Research. - : BMC. - 1465-5411 .- 1465-542X. ; 26:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose One major risk factor for breast cancer is high mammographic density. It has been estimated that dense breast tissue contributes to similar to 30% of all breast cancer. Prevention targeting dense breast tissue has the potential to improve breast cancer mortality and morbidity. Anti-estrogens, which may be associated with severe side-effects, can be used for prevention of breast cancer in women with high risk of the disease per se. However, no preventive therapy targeting dense breasts is currently available. Inflammation is a hallmark of cancer. Although the biological mechanisms involved in the increased risk of cancer in dense breasts is not yet fully understood, high mammographic density has been associated with increased inflammation. We investigated whether low-dose acetylsalicylic acid (ASA) affects local breast tissue inflammation and/or structural and dynamic changes in dense breasts. Methods Postmenopausal women with mammographic dense breasts on their regular mammography screen were identified. A total of 53 women were randomized to receive ASA 160 mg/day or no treatment for 6 months. Magnetic resonance imaging (MRI) was performed before and after 6 months for a sophisticated and continuous measure breast density by calculating lean tissue fraction (LTF). Additionally, dynamic quantifications including tissue perfusion were performed. Microdialysis for sampling of proteins in vivo from breasts and abdominal subcutaneous fat, as a measure of systemic effects, before and after 6 months were performed. A panel of 92 inflammatory proteins were quantified in the microdialysates using proximity extension assay. Results After correction for false discovery rate, 20 of the 92 inflammatory proteins were significantly decreased in breast tissue after ASA treatment, whereas no systemic effects were detected. In the no-treatment group, protein levels were unaffected. Breast density, measured by LTF on MRI, were unaffected in both groups. ASA significantly decreased the perfusion rate. The perfusion rate correlated positively with local breast tissue concentration of VEGF. Conclusions ASA may shape the local breast tissue microenvironment into an anti-tumorigenic state. Trials investigating the effects of low-dose ASA and risk of primary breast cancer among postmenopausal women with maintained high mammographic density are warranted.hic density are warranted.
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| 5. |
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Medborgarskap & digitalisering : en utställning om vardagslivets digitala utmaningar
- 2023
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Konstnärligt arbeteabstract
- Utställningen ”Medborgarskap & digitalisering” gestaltar i olika media de digitala utmaningar vi som medborgare möter i vardagen och har hämtat inspiration från forskning som bedrivs vid LiU av forskargruppen DINO. DINO - Digitalisering i nya offentligheter vid Institutionen för ekonomisk och industriell utveckling (IEI) - studerar hur digitalisering av offentliga tjänster påverkar oss som samhällsmedborgare. Forskargruppen undersöker digitaliseringens effekter på det offentliga samtalet och hur offentliga tjänster görs tillgängliga på nya sätt. En viktig del av deras forskning är också att studera vilka som riskerar att hamna utanför och varför. I många fall blir folkbibliotek ett slags stödfunktion i vardagliga situationer när teknik inte fungerar eller inte är tillgänglig så att medborgare kan agera som aktiva aktörer i samhället. DINO:s studier av de frågor om digitala problem som besökare på biblioteken kommer med har visat att dessa problem påverkar människors möjligheter att agera som medborgare. Det kan till exempel handla om att hantera olika e-tjänster, såsom att boka en tid på vårdcentralen, att betala räkningar, att söka jobb, eller att hantera sitt busskort för att åka kollektivtrafik. Med utgångspunkt i denna forskning presenterar utställningen olika situationer och händelser kopplade till vardagens digitala utmaningar.
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| 6. |
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Tjejer och teknik
- 2019
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Konstnärligt arbeteabstract
- Studier visar att intresset för teknikämnet i skolan sjunker dramatiskt bland flickor mellan årskurs 5 och årskurs 8. Är det verkligen så att flickor tappar allt intresse för teknik eller visar siffrorna på något annat? Ulrika Sultan, doktorand i teknikens didaktik vid Institutionen för samhälls- och välfärdsstudier vid Linköpings universitet, menar att flickor ÄR intresserade av teknik och GÖR teknik hela tiden, men att de inte definierar det de gör som teknik.Arbetsgivarorganisationen Teknikföretagen lyfter fram att för att Sverige ska kunna behålla sin position i framkant när det gäller industriell utveckling och innovation behövs en breddad rekrytering till tekniska yrken.Utställningen tar med besökaren till miljöer där kvinnor, flickor och tjejer i olika åldrar rör sig i teknikens värld. Här lyfts kvinnliga förebilder fram, eldsjälar och föreningar som jobbar för att stärka tjejers tekniska självförtroende.Utställningsperiod 30/8-19/12 2019 (Vallabiblioteket) och 20/1-31/3 2020 (Campus Norrköpings bibliotek)
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