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Sökning: WFRF:(Wik E)

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  • Husby, O., et al. (författare)
  • Dealing with L1 background and L2 dialects in Norwegian CAPT
  • 2011
  • Ingår i: Proceedings of ISCA International Workshop on Speech and Language Technology in Education. - : The International Society for Computers and Their Applications (ISCA).
  • Konferensbidrag (refereegranskat)abstract
    • This article describes the CALST project, in which the primary aim is to develop Ville-N, a CAPT system for learners of Norwegian as a second language. Since there is no accepted pronunciation standard in Norwegian, the system uses four dialects (represented by one male and one female speaker each). Ville-N makes use of L1-L2map, a tool for multi-lingual contrastive analysis, to generate a list of expected pronunciation problems. These can be used to tailor pronunciation and listening exercises. The tool can also be used for other target languages. We propose L1-L2map as a collaborative tool for the CAPT community. Index Terms. CAPT, Ville-N, Norwegian, dialects, multi-lingual contrastive analysis, L1-L2map
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  • Kruger, K, et al. (författare)
  • Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer
  • 2017
  • Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 1089-
  • Tidskriftsartikel (refereegranskat)abstract
    • We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent breast cancer hospital cohorts (Series I-V, total 1257 cases). Also, TCGA proteomic data (n = 103), mRNA microarray data from TCGA (n = 520), METABRIC (n = 1992), and 6 open access breast cancer datasets (n = 1908) were analysed. Patients with Nestin protein expression in tumour cells more often had BRCA1 germline mutations (OR 8.7, p < 0.0005, Series III), especially among younger patients (<40 years at diagnosis) (OR 16.5, p = 0.003). Nestin protein positivity, observed in 9–28% of our hospital cases (Series I-IV), was independently associated with reduced breast cancer specific survival (HR = 2.0, p = 0.035) and was consistently related to basal-like differentiation (by Cytokeratin 5, OR 8.7–13.8, p < 0.0005; P-cadherin OR 7.0–8.9, p < 0.0005; EGFR staining, OR 3.7–8.2, p ≤ 0.05). Nestin mRNA correlated significantly with Nestin protein expression (ρ = 0.6, p < 0.0005), and high levels were seen in the basal-like intrinsic subtype. Gene expression signalling pathways linked to high Nestin were explored, and revealed associations with stem-like tumour features. In summary, Nestin was strongly associated with germline BRCA1 related breast cancer, a basal-like phenotype, reduced survival, and stemness characteristics.
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