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Exploring the genet...
Exploring the genetics of trotting racing ability in horses using a unique Nordic horse model
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- Velie, Brandon (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,University of Sydney,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden;Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia
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- Lillie, Mette (författare)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,Zooekologi,Univ Gothenburg, Dept Biol & Environm Sci, Gothenburg, Sweden
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- Jäderkvist Fegraeus, Kim (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden
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- Rosengren, M. K. (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden
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- Sole, M. (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden
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- Wiklund, Maja (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden
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- Ihler, C. F. (författare)
- Norwegian Univ Life Sci, Dept Compan Anim Clin Sci, Oslo, Norway
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- Strand, E. (författare)
- Norwegian Univ Life Sci, Dept Compan Anim Clin Sci, Oslo, Norway
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- Lindgren, Gabriella (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,University of Leuven (KU Leuven),Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden;Katholieke Univ Leuven, Dept Biosyst, Livestock Genet, Leuven, Belgium
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(creator_code:org_t)
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- 2019-02-04
- 2019
- Engelska.
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Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 20
- Relaterad länk:
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https://bmcgenomics....
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://res.slu.se/i...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BackgroundHorses have been strongly selected for speed, strength, and endurance-exercise traits since the onset of domestication. As a result, highly specialized horse breeds have developed with many modern horse breeds often representing closed populations with high phenotypic and genetic uniformity. However, a great deal of variation still exists between breeds, making the horse particularly well suited for genetic studies of athleticism. To identify genomic regions associated with athleticism as it pertains to trotting racing ability in the horse, the current study applies a pooled sequence analysis approach using a unique Nordic horse model.ResultsPooled sequence data from three Nordic horse populations were used for F-ST analysis. After strict filtering, F-ST analysis yielded 580 differentiated regions for trotting racing ability. Candidate regions on equine chromosomes 7 and 11 contained the largest number of SNPs (n=214 and 147, respectively). GO analyses identified multiple genes related to intelligence, energy metabolism, and skeletal development as potential candidate genes. However, only one candidate region for trotting racing ability overlapped a known racing ability QTL.ConclusionsNot unexpected for genomic investigations of complex traits, the current study identified hundreds of candidate regions contributing to trotting racing ability in the horse. Likely resulting from the cumulative effects of many variants across the genome, racing ability continues to demonstrate its polygenic nature with candidate regions implicating genes influencing both musculature and neurological development.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Annan veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Other Veterinary Science (hsv//eng)
Nyckelord
- Athleticism
- Conformation
- Genomic
- Performance
- Racehorse
- protein families
- performance
- framework
- mutation
- panther
- traits
- Biotechnology & Applied Microbiology
- Genetics & Heredity
- Athleticism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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