| 1. |
- Bankel, Johan, 1959, et al.
(författare)
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Benchmarking engineering curricula with the CDIO syllabus
- 2005
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Ingår i: International Journal of Engineering Education. - 0949-149X. ; 21:1, s. 121-133
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Tidskriftsartikel (refereegranskat)abstract
- Four internationally-renowned universities-Chalmers University of Technology, Linkoping University, Royal Institute of Technology (Sweden), and the Massachusetts Institute of Technology (USA)-developed a benchmark survey that may be used by any engineering school to benchmark curricula for teaching of personal, interpersonal and system building skills. These skills are enumerated in the CDIO Syllabus. Teaching activities were categorized as Introduce, Teach or Utilize, based on intent, time spent, and linkage to learning objectives, assignments and assessment criteria. Interviews were used to collect the data from instructors of the schools' engineering programs. The data was then reduced and analyzed to illuminate patterns of teaching. The results indicate that much effort is expended in covering these topics, but often in an inefficient, uncoordinated and unplanned manner. For example, there are often frequent repetitions of introducing a topic, without ever teaching it. In other instances, students are expected to utilize knowledge without having been taught it. The results of the benchmark survey indicate that a consistent and deliberately designed curriculum in this area could demand no additional resources, yet provide a much more effective education. The survey gives useful indications of how to begin such a curriculum redesign process.
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| 2. |
- Bankel, Johan, et al.
(författare)
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The CDIO syllabus: a comparative study of expected student proficiency
- 2003
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Ingår i: European Journal of Engineering Education. - : Taylor & Francis. - 0304-3797 .- 1469-5898. ; 28:3, s. 297-315
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Tidskriftsartikel (refereegranskat)abstract
- Engineering students must graduate with command of a vast body of technical knowledge. They must possess personal, interpersonal and system-building skills to function in teams, and be prepared to produce products and systems. Their education must have been structured under a curriculum blending ability to combine technical expertise with ethical, innovative, philosophical and humanistic acumen. This paper describes a unique international collaboration among four universities to reform engineering education. The collaborators agreed to a statement of goals, which includes descriptions of knowledge, skills and attitudes vital to an effective education, and codifies proficiency levels expected of graduates. We developed and utilized unique stakeholder surveys both to validate our prototype and to determine desired proficiency levels. This collaboration resulted in The CDIO Syllabus, A Statement of Goals for Undergraduate Engineering Education. The syllabus is both a template and a process that can be used to customize the syllabus to others' programmes. It can define new educational initiatives/and be employed as the basis for rigorous assessment. This paper details how, with the input of industry, academia and others, we employed an engineering problem-solving paradigm to effect our redesign. It outlines the syllabus and the unique process employed to create it.
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| 3. |
- Hsu, Hsiang-Ting, et al.
(författare)
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NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing
- 2016
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Ingår i: Journal of Cell Biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 215:6, s. 875-889
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Tidskriftsartikel (refereegranskat)abstract
- Natural killer (NK) cell activation triggers sequential cellular events leading to destruction of diseased cells. We previously identified lytic granule convergence, a dynein-and integrin signal-dependent movement of lysosome-related organelles to the microtubule-organizing center, as an early step in the cell biological process underlying NK cell cytotoxicity. Why lytic granules converge during NK cell cytotoxicity, however, remains unclear. We experimentally controlled the availability of human ligands to regulate NK cell signaling and promote granule convergence with either directed or nondirected degranulation. By the use of acoustic trap microscopy, we generated specific effector-target cell arrangements to define the impact of the two modes of degranulation. NK cells with converged granules had greater targeted and less nonspecific "bystander" killing. Additionally, NK cells in which dynein was inhibited or integrin blocked under physiological conditions demonstrated increased nondirected degranulation and bystander killing. Thus, NK cells converge lytic granules and thereby improve the efficiency of targeted killing and prevent collateral damage to neighboring healthy cells.
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| 4. |
- Qundos, Ulrika, et al.
(författare)
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Analysis of plasma from prostate cancer patients links decreased carnosine dipeptidase 1 levels to lymph node metastasis
- 2014
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Ingår i: Translational Proteomics. - : Elsevier BV. - 2212-9634 .- 2212-9626. ; 2:1, s. 14-24
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Tidskriftsartikel (refereegranskat)abstract
- There is a need for a better differentiation of aggressive tumors in prostate cancer to design a tailored treatment for each patient, preferably by a minimally invasive analysis of blood samples. In a previous study, we discovered a decrease of plasma levels of carnosine dipeptidase 1 (CNDP1) in association with aggressive prostate cancer. Now this relation has been investigated and characterized further by generating several new antibodies for extended analysis of CNDP1 in plasma. Multi-antibody sandwich assays were developed and applied to 1214 samples from two Swedish cohorts that confirmed decreased levels of CNDP1 in plasma from patients with advanced disease. Therein, data from CNDP1 assays allowed a better differentiation between tumor N stages than clinical tPSA, but did not when classifying T or M stages. Further investigations can now elucidate mechanisms behind decreasing levels of CNDP1 in plasma and primary in regards to lymph node metastasis.
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