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Träfflista för sökning "WFRF:(Wiklund L) "

Search: WFRF:(Wiklund L)

  • Result 1-10 of 412
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  • Jiang, X., et al. (author)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
  • Journal article (peer-reviewed)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
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  • Speliotes, Elizabeth K., et al. (author)
  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
  • 2010
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
  • Journal article (peer-reviewed)abstract
    • Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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  • Wang, Anqi, et al. (author)
  • Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
  • 2023
  • In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:12, s. 2065-2074
  • Journal article (peer-reviewed)abstract
    • The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
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  • Result 1-10 of 412
Type of publication
journal article (355)
conference paper (51)
reports (2)
book chapter (2)
other publication (1)
research review (1)
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Type of content
peer-reviewed (343)
other academic/artistic (69)
Author/Editor
Wiklund, F (99)
Wiklund, P (85)
Gronberg, H (75)
Kote-Jarai, Z (52)
Schleutker, J (49)
Haiman, CA (45)
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Kibel, AS (43)
Travis, RC (43)
Muir, K (42)
Stanford, JL (42)
Maier, C (42)
Brenner, H (41)
Giles, GG (40)
Al Olama, AA (40)
Batra, J (40)
Cybulski, C (39)
Teixeira, MR (38)
Kaneva, R (38)
Nordestgaard, BG (37)
Cannon-Albright, L (37)
Eeles, RA (37)
Berndt, SI (35)
Khaw, KT (34)
Pashayan, N (34)
Neal, DE (34)
Thibodeau, SN (33)
Egevad, L (32)
Benlloch, S (32)
Albanes, D (31)
Pandha, H (30)
Easton, DF (29)
Kraft, P (29)
Hamdy, FC (29)
Park, JY (29)
Hunter, DJ (28)
Donovan, JL (28)
Wiklund, Fredrik (27)
Henderson, BE (27)
Aly, M (27)
Wiklund, NP (26)
Le Marchand, L (25)
John, EM (24)
Mottrie, A (23)
Conti, DV (23)
Lindstrom, S (23)
Schumacher, FR (23)
Hosseini, A. (22)
Richstone, L (22)
Xu, JF (22)
Ingles, SA (22)
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University
Karolinska Institutet (276)
University of Gothenburg (63)
Uppsala University (60)
Umeå University (55)
Lund University (11)
Mälardalen University (10)
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Linköping University (9)
Royal Institute of Technology (5)
Stockholm University (4)
Högskolan Dalarna (4)
Jönköping University (3)
Mid Sweden University (3)
Karlstad University (3)
Luleå University of Technology (2)
Örebro University (2)
Linnaeus University (2)
RISE (2)
Halmstad University (1)
University of Skövde (1)
University of Borås (1)
Blekinge Institute of Technology (1)
Marie Cederschiöld högskola (1)
Swedish University of Agricultural Sciences (1)
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Language
English (406)
Swedish (3)
Danish (1)
Norwegian (1)
Undefined language (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (100)
Natural sciences (26)
Engineering and Technology (12)
Social Sciences (5)
Agricultural Sciences (1)
Humanities (1)

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