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Histopathological c...
Histopathological classification of pseudomyxoma peritonei and the prognostic importance of PINCH protein
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- Andreasson, Håkan (författare)
- Uppsala universitet,Kolorektalkirurgi,Uppsala University
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- Wanders, Alkwin (författare)
- Uppsala universitet,Molekylär och morfologisk patologi,Alafuzoff,Uppsala University
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- Sun, Xiao-Feng (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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- Willen, Roger (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala University
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- Graf, Wilhelm (författare)
- Uppsala universitet,Kolorektalkirurgi,Uppsala University
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- Nygren, Peter (författare)
- Uppsala universitet,Enheten för onkologi,Uppsala University
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- Glimelius, Bengt (författare)
- Uppsala universitet,Enheten för onkologi,Uppsala University
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- Zhang, Zhi-Yong (författare)
- Tangshan Gongren Hospital
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- Mahteme, Haile (författare)
- Uppsala universitet,Kolorektalkirurgi,Uppsala University
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(creator_code:org_t)
- International Institute of Anticancer Research (IIAR), 2012
- 2012
- Engelska.
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Ingår i: Anticancer Research. - : International Institute of Anticancer Research (IIAR). - 0250-7005 .- 1791-7530. ; 32:4, s. 1443-1448
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Abstract
Ämnesord
Stäng
- AIM: The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP.MATERIALS AND METHODS: Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables.RESULTS: The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04).CONCLUSION: The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Nyckelord
- Adaptor Proteins
- Signal Transducing/*physiology
- Adult
- Aged
- Female
- Humans
- LIM Domain Proteins/*physiology
- Male
- Membrane Proteins/physiology
- Middle Aged
- Prognosis
- Pseudomyxoma Peritonei/*metabolism
- Pathology
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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