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Träfflista för sökning "WFRF:(Willer CJ) srt2:(2015-2019);lar1:(ki)"

Search: WFRF:(Willer CJ) > (2015-2019) > Karolinska Institutet

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1.	Ehret, GB, et al. (author) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals 2016 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 48:10, s. 1171-1184 Journal article (peer-reviewed)
2.	Liu, DJ, et al. (author) Exome-wide association study of plasma lipids in >300,000 individuals 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:12, s. 1758- Journal article (peer-reviewed)
3.	Ferreira, MA, et al. (author) Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:12, s. 1752- Journal article (peer-reviewed)
4.	Guo, DC, et al. (author) Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections 2016 In: American journal of human genetics. - : Elsevier BV. - 1537-6605 .- 0002-9297. ; 99:3, s. 762-769 Journal article (peer-reviewed)
5.	Lane, JM, et al. (author) Biological and clinical insights from genetics of insomnia symptoms 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:3, s. 387- Journal article (peer-reviewed)
6.	Yang, B, et al. (author) Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve 2017 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8, s. 15481- Journal article (peer-reviewed)abstract Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor for valvulopathy and aortopathy. Here we report a genome-wide association scan of 466 BAV cases and 4,660 age, sex and ethnicity-matched controls with replication in up to 1,326 cases and 8,103 controls. We identify association with a noncoding variant 151 kb from the gene encoding the cardiac-specific transcription factor, GATA4, and near-significance for p.Ser377Gly in GATA4. GATA4 was interrupted by CRISPR-Cas9 in induced pluripotent stem cells from healthy donors. The disruption of GATA4 significantly impaired the transition from endothelial cells into mesenchymal cells, a critical step in heart valve development.

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Type of publication: journal article (6)

Type of content: peer-reviewed (6)

Author/Editor: Hveem, K (4); Eriksson, P (3); Boerwinkle, E (3); Holmen, OL (3); Kathiresan, S (3); Hottenga, JJ (2); show more...; Jansen, R (2); Peters, A (2); Langenberg, C. (2); Yang, B (2); Boomsma, DI (2); Loos, RJF (2); Abecasis, G (2); Melander, Olle (2); Bis, JC (2); Smith, AV (2); Gudnason, V (2); Psaty, BM (2); Rotter, JI (2); Fornage, M (2); Folkersen, L (2); Ferrieres, J (2); Kanoni, S (2); Dedoussis, G. (2); Muller-Nurasyid, M. (2); Deloukas, P. (2); Renström, Frida (2); Rasheed, A (2); Saleheen, D (2); Tuomilehto, J. (2); Franco-Cereceda, A (2); Virtamo, J (2); Kuusisto, J. (2); Laakso, M. (2); McCarthy, MI (2); Kang, HM (2); Esko, T (2); Stringham, HM (2); Jackson, AU (2); Palmer, CNA (2); Rauramaa, R (2); Wareham, NJ (2); Metspalu, A (2); Gieger, C (2); Danesh, J (2); Salomaa, V (2); Frayling, TM (2); Boehnke, M (2); Jarvelin, MR (2); Taylor, KD (2); show less...

University: Karolinska Institutet (6)Undo refine; Umeå University (2); Lund University (2); Uppsala University (1)

Language: English (6)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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