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Sökning: WFRF:(Wisén Anita)

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1.
  • Gustafsson, Anna, et al. (författare)
  • Effects of Acute Exercise on Circulating Soluble Form of the Urokinase Receptor in Patients With Major Depressive Disorder
  • 2017
  • Ingår i: Biomarker Insights. - : Sage Publications. - 1177-2719 .- 1177-2719. ; 12, s. 1-6
  • Tidskriftsartikel (refereegranskat)abstract
    • Inflammation has been proposed to play a role in the generation of depressive symptoms. Previously, we demonstrated that patients with major depressive disorder (MDD) have increased plasma levels of the soluble form of the urokinase receptor (suPAR), a marker for low-grade inflammation. The aim of this study was to test the hypothesis that acute exercise would induce inflammatory response characterized by increased suPAR and elucidate whether patients with MDD display altered levels of suPAR in response to acute exercise. A total of 17 patients with MDD and 17 controls were subjected to an exercise challenge. Plasma suPAR (P-suPAR) was analyzed before, during, and after exercise. There was a significantly higher baseline P-suPAR in the patients with MDD, and the dynamic changes of P-suPAR during the exercise were significantly lower in the patients with MDD, compared with the controls. This study supports the hypothesis that an activation of systemic inflammatory processes, measured as elevated P-suPAR, is involved in the pathophysiology of depression. The study concludes that P-suPAR is influenced by acute exercise, most likely due to release from activated neutrophils.
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2.
  • Wisén, Anita, et al. (författare)
  • Plasma ANP and BNP during exercise in patients with major depressive disorder and in healthy controls.
  • 2011
  • Ingår i: Journal of Affective Disorders. - : Elsevier. - 1573-2517 .- 0165-0327. ; 129:1-3, s. 371-375
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Increased levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been shown to reduce the hormones in the HPA axis. In this study we addressed the question whether patients with unmedicated major depressive disorder (MDD) might have altered baseline levels of these natriuretic peptides and an altered response to acute exercise. METHODS: An incremental exercise test was performed in 18 patients with MDD and in 18 healthy controls. Plasma concentrations of ANP and BNP were determined at rest, during the exercise test and 30min post exercise using immunoradiometric assays. RESULTS: During the exercise test the concentrations of ANP and BNP increased significantly in both groups. The MDD group showed significantly lower levels of ANP than the controls at rest, at maximal work rate and post exercise and of BNP at rest and at maximal work rate. The dynamic changes of both ANP and BNP, respectively, from baseline to maximal work rate were significantly lower in the MDD group. A slightly lower (non-significant) maximal work rate was observed in the MDD group compared with the controls. LIMITATIONS: Group sizes are relatively limited. CONCLUSION: Lower concentrations of ANP and BNP during rest and exercise were observed in the MDD patients together with a decreased dynamic response to maximal exercise. Hypothetically, the reduced ANP and BNP concentration contributes to the high hormone levels in the HPA system seen in depressive disorders. Of interest for future research is whether physical training might increase the levels of ANP and BNP and thereby diminish depressive symptoms.
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5.
  • Engstrom, Elise, et al. (författare)
  • Comparison of heart rate measured by Polar RS400 and ECG, validity and repeatability
  • 2012
  • Ingår i: Advances in Physiotherapy. - : Informa Healthcare. - 1403-8196 .- 1651-1948. ; 14:3, s. 115-122
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: The purpose of this study was to investigate criterion-related validity and testretest repeatability of the heart rate monitor Polar RS400 versus electrocardiogram (ECG). Methodology: Ten healthy subjects, 19-34 years, performed a cycle ergometer test 5 min on each load (50, 100 and 150 W). Heart rate (HR) was measured with ECG and Polar RS400 and recorded digitally. After at least one hour resting the test was repeated. Major findings: The results showed a significant correlation between HR measured by ECG and by Polar RS400 with correlation coefficients ranging from 0.97 to 1.00. In test 1 the mean difference ±2SD between HR Polar and HR ECG was 0.7±4.3 bpm and in test 2, 0.2±3.2 bpm. In the repeated tests, the mean difference of HR between test 2 and test 1±2SD was 3.2±11.9 bpm with ECG and 2.6±14.3 bpm with Polar RS400 and these differences were not statistically significant. Conclusion: This study indicates good criterion-related validity and testretest repeatability of Polar RS400. Differences observed at individual levels should be noticed, but are not considered to be clinically important. Polar RS400 is thus well suited for recording HR during physical activity and exercise training. © 2012 Informa Healthcare.
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6.
  • Engström, E, et al. (författare)
  • Comparison of heart rate measured by Polar RS 400 and ECG, validity and repeatability .
  • 2012
  • Ingår i: Advances in Physiotherapy. - : Taylor & Francis. - 1651-1948. ; 14:3, s. 115-122
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: The purpose of this study was to investigate criterion-related validity and test–retest repeatability of the heart rate monitor Polar RS400 versus electrocardiogram (ECG). Methodology: Ten healthy subjects, 19–34 years, performed a cycle ergometer test 5 min on each load (50, 100 and 150 W). Heart rate (HR) was measured with ECG and Polar RS400 and recorded digitally. After at least one hour resting the test was repeated. Major findings: The results showed a significant correlation between HR measured by ECG and by Polar RS400 with correlation coefficients ranging from 0.97 to 1.00. In test 1 the mean difference ± 2SD between HR Polar and HR ECG was 0.7 ± 4.3 bpm and in test 2, 0.2 ± 3.2 bpm. In the repeated tests, the mean difference of HR between test 2 and test 1 ± 2SD was 3.2 ± 11.9 bpm with ECG and 2.6 ± 14.3 bpm with Polar RS400 and these differences were not statistically significant. Conclusion: This study indicates good criterion-related validity and test–retest repeatability of Polar RS400. Differences observed at individual levels should be noticed, but are not considered to be clinically important. Polar RS400 is thus well suited for recording HR during physical activity and exercise training.
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7.
  • Garland, Stephen, et al. (författare)
  • Is Ross treadmill method an alternative to Åstrand cycle ergometer method?
  • Ingår i: European Journal of Physiotherapy. - : Informa Healthcare. - 2167-9169. ; 19:3, s. 167-172
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: To assess the agreement between the Ross treadmill method and the Åstrand ergometer cycle method, and the repeatability of each method. Methodology: Twenty healthy people aged 22.5 ± 2.2 years were tested on two different days, each day with both methods with a pause of 30 min between the tests. The tests were executed in the reverse order the following test day. Major findings: There was no statistical difference between the methods. The correlation (R) between the methods was 0.85. The mean difference (95% CI) of the methods was 0.050 (0.046–0.054) L/min and the limit of the agreement (mean difference ±2SD) was 0.81 L/min. No significant differences in test-retest were shown for either test. The mean difference for Åstrand tests was 0.12 L/min and 0.08 L/min for the Ross tests. The coefficient of repeatability was 0.88 L/min (23%) for the Åstrand test, and 0.78 L/min (20%) for the Ross test. Conclusion: The Ross treadmill test could be used as an alternative to the Åstrand cycle ergometer test, showing good agreement and repeatability. The large variation should be considered when estimating aerobic capacity on an individual level, although either method could be used for group studies where maximal measurements are not possible.
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8.
  • Gustafsson, Gunnar, et al. (författare)
  • The acute response of plasma brain-derived neurotrophic factor as a result of exercise in major depressive disorder.
  • 2009
  • Ingår i: Psychiatry Research. - : Elsevier. - 1872-7123. ; 169:3, s. 244-248
  • Tidskriftsartikel (refereegranskat)abstract
    • Brain-derived neurotrophic factor (BDNF) and other neurotrophins are believed to play an important role in affective disorders. In this study we investigated plasma-BDNF response during an incremental exercise test in 18 patients suffering from moderate major depressive disorder (MDD) and 18 controls. The patients were not treated with antidepressants or neuroleptics. Possible associations between plasma plasma-BDNF levels, dexamethasone suppression test cortisol levels and Montgomery-Asberg Depression Rating Scale (MADRS) scores were also tested. No difference in basal BDNF levels between patients and controls was found. BDNF increased significantly during exercise in both male and female patients as well as in male controls, with no significant differences between the groups. BDNF levels declined after exercise, but after 60 min of rest BDNF levels showed tendencies to increase again in male patients. No correlation between BDNF and cortisol or MADRS scores was found. We conclude that unmedicated patients with moderate depression and normal activity of the hypothalamic-pituitary-adrenal axis do not have a disturbed peripheral BDNF release during exercise. The BDNF increase 60 min after interruption of exercise in male patients might indicate up-regulated BDNF synthesis, but this needs to be further investigated in future studies.
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9.
  • Hagströmer, Maria, et al. (författare)
  • Att bedöma och utvärdera fysisk aktivitet vid rådgivning i vården.
  • 2015
  • Ingår i: Läkartidningen. - : Swedish Medical Association. - 0023-7205. ; 112
  • Tidskriftsartikel (refereegranskat)abstract
    • To make individualized counseling possible, valid and reliable measures of physical activity are necessary. In health care, quality must be continuously secured and developed. Follow-up of life-style habits such as physical activity does not differ from monitoring of other treatment in the health care setting. After counseling and appropriate period of time, evaluation should be done to assess if there has been any change in the physical activity level. For assessment and evaluation of physical activity in routine clinical practice the National Board for Health and Social Welfare indicator questions regarding physical activity are recommended. For a more detailed assessment and evaluation of physical activity and sedentary behavior comprehensive validated instruments/diaries should be used. For precise and objective assessment and evaluation of both physical activity and sedentary behavior, movement sensors are recommended.
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10.
  • Hagströmer, M, et al. (författare)
  • Bedöma och utvärdera fysisk aktivitet
  • 2015
  • Ingår i: FYSS Fysisk aktivitet i sjukdomsprevention och sjukdomsbehandling.
  • Bokkapitel (populärvet., debatt m.m.)
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