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Sökning: WFRF:(Wisniewski John) > Kungliga Tekniska Högskolan

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  • Boutajangout, Allal, et al. (författare)
  • Affibody-Mediated Sequestration of Amyloid beta Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model
  • 2019
  • Ingår i: Frontiers in Aging Neuroscience. - : Frontiers Media S.A.. - 1663-4365. ; 11
  • Tidskriftsartikel (refereegranskat)abstract
    • Different strategies for treatment and prevention of Alzheimer's disease (AD) are currently under investigation, including passive immunization with anti-amyloid beta (anti-A beta) monoclonal antibodies (mAbs). Here, we investigate the therapeutic potential of a novel type of A beta-targeting agent based on an affibody molecule with fundamentally different properties to mAbs. We generated a therapeutic candidate, denoted Z(SYM73)-albumin-binding domain (ABD; 16.8 kDa), by genetic linkage of the dimeric Z(SYM73) affibody for sequestering of monomeric A beta-peptides and an ABD for extension of its in vivo half-life. Amyloid precursor protein (APP)/PS1 transgenic AD mice were administered with Z(SYM73)-ABD, followed by behavioral examination and immunohistochemistry. Results demonstrated rescued cognitive functions and significantly lower amyloid burden in the treated animals compared to controls. No toxicological symptoms or immunology-related side-effects were observed. To our knowledge, this is the first reported in vivo investigation of a systemically delivered scaffold protein against monomeric A beta, demonstrating a therapeutic potential for prevention of AD.
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  • Kragelund, Martin, et al. (författare)
  • Profit Maximization of a Power Plant
  • 2012
  • Ingår i: European Journal of Control. - 0947-3580 .- 1435-5671. ; 18:1, s. 38-54
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper addresses the problem of profit maximization of a power plant by utilizing three different fuel systems in an optimal manner Pontryagin's maximum principle is used to derive properties of the optimal control strategy. These properties give rise to a switching function. Subsequently, certain heuristics are introduced and used in combination with discrete optimization to obtain an initial trajectory of the switching function. An iterative procedure is proposed, which uses the initial trajectory for the computation of the optimal control strategy. The control strategy derived is a combination of a state feedback and time-varying feedforward term. Its performance is tested against input noise.
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  • Resultat 1-4 av 4

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