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- Gustafsson, Karin M, 1983-, et al.
(författare)
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Science-Policy-Practice Interfaces : Emergent knowledge and monarch butterfly conservation
- 2017
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Ingår i: Environmental Policy and Governance. - : John Wiley & Sons. - 1756-932X .- 1756-9338. ; 27:6, s. 521-533
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Tidskriftsartikel (refereegranskat)abstract
- We study how knowledge is produced at the intersection of science, environmental policy and public engagement. Based on analysis of monarch butterfly conservation, we critically evaluate models of knowledge production. The monarch butterfly and its migration have engaged science and enchanted people for over a century, and current threats to monarchs catalyze debates and actions. This paper traces the historical development of knowledge regarding (i) long-term monarch population trends, (ii) the monarch’s dependence on a particular food plant, the milk-weed, and (iii) the monarch as a pollinator. Our analysis indicates that knowledge production and science–policy–practice interfaces cannot be satisfactorily understood through reference to the classical linear model and more recent conceptions of relationally produced knowledge (i.e. co-production). We identify powerful and sometimes contradictory knowledge claims that emerge from unmediated interactions among scientists, advocates, policy makers and diverse publics. The emergent model complements existing models of knowledge production, thereby expanding the conceptual foundation available for making sense of science–policy–practice interfaces.
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- Gustafsson, Karin M., 1983-, et al.
(författare)
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The Monarch Butterfly through Time and Space : The Social Construction of an Icon
- 2015
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Ingår i: BioScience. - : Oxford University Press. - 0006-3568 .- 1525-3244. ; 65:6, s. 612-622
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we explore the social construction of the monarch butterfly as a conservation icon in order to understand how the butterfly has come to be endowed with the power to shape public conversations and potentially alter policy and practice. Our analysis is guided by the sociological concepts of coproduction and boundary objects, which reveal how this butterfly has animated and sustained conversations across diverse organizational boundaries. We find that engagement with narratives of beauty, natural wonder, scientific discovery, conservation imperatives, and civic duty has allowed the monarch to enroll actors in a broad network that gives rise to surprising, emergent properties. These properties make the monarch a powerful communication vehicle and a potent ally in environmental politics. Our analysis of the historical and contemporary construction of the monarch as an icon contributes to ongoing efforts to bring resources from critical social science to bear on the strengthening of science-policy–practice interfaces.
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- Wolf, A., et al.
(författare)
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Prediction of violent crime on discharge from secure psychiatric hospitals : A clinical prediction rule (FoVOx)
- 2018
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Ingår i: European psychiatry. - : Elsevier. - 0924-9338 .- 1778-3585. ; 47, s. 88-93
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Tidskriftsartikel (refereegranskat)abstract
- Background: Current approaches to assess violence risk in secure hospitals are resource intensive, limited by accuracy and authorship bias and may have reached a performance ceiling. This study seeks to develop scalable predictive models for violent offending following discharge from secure psychiatric hospitals.Methods: We identified all patients discharged from secure hospitals in Sweden between January 1, 1992 and December 31, 2013. Using multiple Cox regression, pre-specified criminal, sociodemographic, and clinical risk factors were included in a model that was tested for discrimination and calibration in the prediction of violent crime at 12 and 24 months post-discharge. Risk cut-offs were pre-specified at 5% (low vs. medium) and 20% (medium vs. high).Results: We identified 2248 patients with 2933 discharges into community settings. We developed a 12-item model with good measures of calibration and discrimination (area under the curve = 0.77 at 12 and 24 months). At 24 months post-discharge, using the 5% cut-off, sensitivity was 96% and specificity was 21%. Positive and negative predictive values were 19% and 97%, respectively. Using the 20% cut-off, sensitivity was 55%, specificity 83% and the positive and negative predictive values were 37% and 91%, respectively. The model was used to develop a free online tool (FoVOx).Interpretation: We have developed a prediction score in a Swedish cohort of patients discharged from secure hospitals that can assist in clinical decision-making. Scalable predictive models for violence risk are possible in specific patient groups and can free up clinical time for treatment and management. Further evaluation in other countries is needed.Funding: Wellcome Trust (202836/Z/16/Z) and the Swedish Research Council. The funding sources had no involvement in writing of the manuscript or decision to submit or in data collection, analysis or interpretation or any aspect pertinent to the study.
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- De Bourdeaudhuij, I, et al.
(författare)
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Personal, social and environmental predictors of daily fruit and vegetable intake in 11-year-old children in nine European countries
- 2008
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Ingår i: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 0954-3007 .- 1476-5640. ; 62:7, s. 834-841
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate potential personal, social and physical environmental predictors of daily fruit intake and daily vegetable intake in 11-year-old boys and girls in nine European countries.SUBJECTS: The total sample size was 13 305 (90.4% participation rate).RESULTS: Overall, 43.2% of the children reported to eat fruit every day, 46.1% reported to eat vegetables every day. Daily fruit intake and daily vegetable intake was mainly associated with knowledge of the national recommendations, positive self-efficacy, positive liking and preference, parental modeling and demand and bringing fruit to school (odds ratio between 1.40 and 2.42, P<0.02). These factors were associated fairly consistently with daily fruit intake across all nine European countries, implying that a rather uniform intervention strategy to promote fruit can be used across Europe. For vegetables, the pattern was, however, less consistent. Differences between countries in cooking and preparing vegetables might be responsible for this larger diversity.CONCLUSIONS: This study showed that especially a combination of personal and social factors is related to daily fruit and vegetable intake in schoolchildren. This shows that a comprehensive multilevel intervention strategy based upon a series of individual and social correlates will be most promising in the promotion of daily fruit and vegetable intake in children.
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- Kennedy, Beatrice, 1982-, et al.
(författare)
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App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- The app-based COVID Symptom Study was launched in Sweden in April 2020 to contribute to real-time COVID-19 surveillance. We enrolled 143,531 study participants (≥18 years) who contributed 10.6 million daily symptom reports between April 29, 2020 and February 10, 2021. Here, we include data from 19,161 self-reported PCR tests to create a symptom-based model to estimate the individual probability of symptomatic COVID-19, with an AUC of 0.78 (95% CI 0.74-0.83) in an external dataset. These individual probabilities are employed to estimate daily regional COVID-19 prevalence, which are in turn used together with current hospital data to predict next week COVID-19 hospital admissions. We show that this hospital prediction model demonstrates a lower median absolute percentage error (MdAPE: 25.9%) across the five most populated regions in Sweden during the first pandemic wave than a model based on case notifications (MdAPE: 30.3%). During the second wave, the error rates are similar. When we apply the same model to an English dataset, not including local COVID-19 test data, we observe MdAPEs of 22.3% and 19.0% during the first and second pandemic waves, respectively, highlighting the transferability of the prediction model.
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- Seibert, Volker, et al.
(författare)
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Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p
- 2002
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Ingår i: BMC Biochemistry. - London, United Kingdom : BioMed Central (BMC). - 1471-2091. ; 3, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Background: SCF ubiquitin ligases share the core subunits cullin 1, SKP1, and HRT1/RBX1/ROC1, which associate with different F-box proteins. F-box proteins bind substrates following their phosphorylation upon stimulation of various signaling pathways. Ubiquitin-mediated destruction of the fission yeast cyclin-dependent kinase inhibitor Rum1p depends on two heterooligomerizing F-box proteins, Pop1p and Pop2p. Both proteins interact with the cullin Pcu1p when overexpressed, but it is unknown whether this reflects their co-assembly into bona fide SCF complexes.Results: We have identified Psh1p and Pip1p, the fission yeast homologues of human SKP1 and HRT1/RBX1/ROC1, and show that both associate with Pop1p, Pop2p, and Pcu1p into a ~500 kDa SCFPop1p-Pop2p complex, which supports polyubiquitylation of Rum1p. Only the F-box of Pop1p is required for SCFPop1p-Pop2p function, while Pop2p seems to be attracted into the complex through binding to Pop1p. Since all SCFPop1p-Pop2p subunits, except for Pop1p, which is exclusively nuclear, localize to both the nucleus and the cytoplasm, the F-box of Pop2p may be critical for the assembly of cytoplasmic SCFPop2p complexes. In support of this notion, we demonstrate individual SCFPop1p and SCFPop2p complexes bearing ubiquitin ligase activity.Conclusion: Our data suggest that distinct homo- and heterooligomeric assemblies of Pop1p and Pop2p generate combinatorial diversity of SCFPop function in fission yeast. Whereas a heterooligomeric SCFPop1p-Pop2p complex mediates polyubiquitylation of Rum1p, homooligomeric SCFPop1p and SCFPop2p complexes may target unknown nuclear and cytoplasmic substrates.
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