| 1. |
- Eriksson, Jonas, et al.
(författare)
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Small Molecule Screening for Inhibitors of the YopH Phosphatase of Yersinia pseudotuberculosis
- 2012
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Ingår i: Advances in Yersinia Research. - New York : Springer. - 9781461435600 - 9781461435617 ; , s. 357-363
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Bokkapitel (refereegranskat)abstract
- Bacterial virulence systems are attractive targets for development of new antibacterial agents. Yersinia spp. utilize the type III secretion (T3S) system to secrete and translocate Yersinia outer proteins (Yop effectors) into the cytosol of the target cell and thereby overcome host defenses to successfully establish an infection. Thus, the Yop effectors constitute attractive targets for drug development. In the present study we apply small molecule screening to identify inhibitors of one of the secreted proteins YopH, a tyrosine phosphatase required for virulence. Characterization of seven inhibitors indicated that both competitive and noncompetitive inhibitors were identified with IC50 values of 6–20 μM.
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| 2. |
- Giwercman, Y. L., et al.
(författare)
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Sexual differentiation and development
- 2006
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Ingår i: Andrology for the Clinician. - 3540231714 - 9783540231714 ; , s. 266-272
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Bokkapitel (refereegranskat)abstract
- Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to initiate a proper diagnostic procedure, preferably done by a specialist team. Diagnosis generally requires a thorough clinical examination of the child and careful family history taking. The further diagnostic procedure includes cytogenetic hormonal and mutational analyses before sex assignment. Advances in molecular genetics are continuously providing tools for the detection of genetic defects and the primary diagnosis of intersex disorders. These methods may also be applied to prenatal diagnosis and carrier identification.
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| 3. |
- Westerhoff, Lisa, 1980-, et al.
(författare)
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Planned adaptation measures in industrialised countries : a comparison of select countries within and outside the EU
- 2010
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Ingår i: Developing Adaptation Policy and Pracitce in Europe. - Berlin : Springer. - 9789048193257 - 9789048193240 ; , s. 271-338
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter provides a context for the discussion on the emergence of adaptation measures in the four case studies presented in this volume through a brief discussion of the ways in which planned adaptations are being developed in eight European countries Adaptation actions at different levels in Austria, France, Germany, Greece, Hungary, the Netherlands, Norway and Spain are described in order to provide an illustration of adaptation measures in a range of countries representing differing structural contexts, modes of decentralisation and histories of engagement in environmental policy An additional section on planned adaptation as it has manifested in Canada and Australia is also presented to provide further ground for comparison with countries outside the European context Results show a tenuous link between the extent to which countries have engaged in adaptation and their environmental policy implementation record, though some interesting links between environmental policy institutions and adaptation can be made The extent to which unitary and federal nations have decentralised responsibility to sub-national tiers is shown to have an impact on the way in which regions and local authorities have engaged in adaptation The role of both NGOs and the European Union is shown to be of significance to regional and local governments, as well as those countries who have not yet extensively engaged in adaptation at the national scale.
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| 4. |
- Wolf, M., et al.
(författare)
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Designing Augmented Reality Applications as Learning Activity
- 2020
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Ingår i: Augmented Reality in Education. - Cham : Springer. ; , s. 23-43
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Bokkapitel (refereegranskat)abstract
- This chapter examines the conceptual design of AR applications as a learning activity with low technical requirements. With the help of the learning activity, the principles of AR and of the subject area can be conveyed, and the learners’ engagement with the learning content should be stimulated. In this study, Bachelor students of civil engineering (N = 71) have been assigned the task of designing an AR application for the subject domain of technical infrastructures, such as traffic management or energy supply. The students describe the design of the AR application with an own photo shot of the technical infrastructure with the augmentation on the photo and an explanatory text of 100–200 words. Combined these three elements serve as an illustration, which is made available to fellow students in an online gallery for peer review by means of a questionnaire. The peer review is intended both to examine the quality of the contributions—and thus possible learning outcomes among the submitters—and to stimulate the reviewers to engage with AR and the subject domain. A subsequent survey evaluates the students' assessment of learning success. Although the study only suggests actual learning outcomes of the learning activity, it demonstrates how complex technologies, such as AR, can be integrated into learning contexts with low technical requirements.
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