| 1. |
- Aaltonen, H. Laura, et al.
(författare)
-
Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
- 2021
-
Ingår i: Thorax. - : BMJ. - 0040-6376 .- 1468-3296. ; 76:10, s. 1040-1043
-
Tidskriftsartikel (refereegranskat)abstract
- Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.
|
|
| 2. |
|
|
| 3. |
- Jakobsson, Jonas K F, et al.
(författare)
-
Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease
- 2018
-
Ingår i: BMC Pulmonary Medicine. - : BioMed Central Ltd.. - 1471-2466. ; 18:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease. Methods: Lung deposition of nanoparticles (50 and 100 nm) was measured after a 10 s breath-hold for three groups: healthy never-smoking subjects (n = 17), asymptomatic (active and former) smokers (n = 15) and subjects with chronic obstructive pulmonary disease (n = 16). Measurements were made at 1300 mL and 1800 mL volumetric lung depth. Each subject also underwent conventional lung function tests, including post bronchodilator FEV1, VC, and diffusing capacity for carbon monoxide, DL,CO. Patients with previously diagnosed respiratory disease underwent a CT-scan of the lungs. Particle lung deposition fraction, was compared between the groups and with conventional lung function tests. Results: We found that the deposition fraction was significantly lower for subjects with emphysema compared to the other subjects (p = 0.001-0.01), but no significant differences were found between healthy never-smokers and smokers. Furthermore, the particle deposition correlated with pulmonary function tests, FEV1%Pred (p < 0.05), FEV1/VC%Pred (p < 0.01) and DL,CO (p < 0.0005) when all subjects were included. Furthermore, for subjects with emphysema, deposition fraction correlated strongly with DL,CO (Pearson's r = 0.80-0.85, p < 0.002) while this correlation was not found within the other groups. Conclusions: Lower deposition fraction was observed for emphysematous subjects and this can be explained by enlarged distal airspaces in the lungs. As expected, deposition increases for smaller particles and deeper inhalation. The observed results have implications for exposure assessment of air pollution and dosimetry of aerosol-based drug delivery of nanoparticles.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Petersson-Sjögren, Madeleine, et al.
(författare)
-
Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests
- 2022
-
Ingår i: International Journal of Nanomedicine. - : Dove Medical Press Ltd. - 1176-9114 .- 1178-2013. ; 17, s. 2777-2790
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent. Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques. © 2022 Petersson-Sjögren et al.
|
|
| 8. |
|
|
| 9. |
- Rissler, Jenny, et al.
(författare)
-
A set-up for respiratory tract deposition efficiency measurements (15–5000 nm) and first results for a group of children and adults
- 2017
-
Ingår i: Aerosol and Air Quality Research. - : AAGR Aerosol and Air Quality Research. - 1680-8584 .- 2071-1409. ; 17:6, s. 1244-1255
-
Tidskriftsartikel (refereegranskat)abstract
- Exposure to airborne particulate matter is associated with a number of negative health effects ranging from respiratorydiseases to systemic effects and cancer. One important factor for understanding the health effects is the individual variationin the respiratory tract deposition of inhaled particles. In this study, we describe an experimental set-up for size-resolvedmeasurements of the lung deposited fraction of airborne particles, covering the diameter range from 15 to 5000 nm. Theset-up includes a system for generating a stable aerosol with a sufficiently broad size distribution. We used a scanningmobility particle sizer and an aerodynamic particle sizer to determine particle number and size. The set-up was used toinvestigate individual differences in the deposition fraction (DF) of particles in the respiratory tract for a group of 67subjects of both sexes aged 7–70 years. The measured DF was applied to two model aerosols, one representing an urbanenvironment and one a rural environment, and the particle deposition rates were derived (i.e., the deposited amount ofparticles per unit time). Furthermore, the deposition rates were normalized to lung surface area and body mass – two dosemeasures that are considered relevant for the health effects of airborne particles. In addition to validation of the set-up, weshow that there is a large individual variation in DF, with some subjects having a DF that is more than twice as high as thatof others. Although we observe differences in the DF between different subgroups, most individual variation wasexplained neither by age nor by gender. When normalizing the deposition rates to lung surface area or body mass, thedeposition rates of children become significantly higher than those of adults. Furthermore, the individual variability islarger for the lung surface area or body mass normalized deposition rates than for DF
|
|
| 10. |
|
|
