SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wright Adam) ;pers:(Amin Najaf)"

Sökning: WFRF:(Wright Adam) > Amin Najaf

  • Resultat 1-3 av 3
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Hibar, Derrek P., et al. (författare)
  • Novel genetic loci associated with hippocampal volume
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
  •  
2.
  • Evangelou, Evangelos, et al. (författare)
  • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
  • 2018
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
  • Tidskriftsartikel (refereegranskat)abstract
    • High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
  •  
3.
  • Locke, Adam E, et al. (författare)
  • Genetic studies of body mass index yield new insights for obesity biology.
  • 2015
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-3 av 3
Typ av publikation
tidskriftsartikel (3)
Typ av innehåll
refereegranskat (3)
Författare/redaktör
Amin, Najaf (3)Ta bort avgränsningen
van Duijn, Cornelia ... (3)
Salomaa, Veikko (2)
Perola, Markus (2)
Lind, Lars (2)
Raitakari, Olli T (2)
visa fler...
Campbell, Harry (2)
Rudan, Igor (2)
Strachan, David P (2)
Wareham, Nicholas J. (2)
Laakso, Markku (2)
Ridker, Paul M. (2)
Chasman, Daniel I. (2)
Rose, Lynda M (2)
Langenberg, Claudia (2)
Boehnke, Michael (2)
Hamsten, Anders (2)
Scott, Robert A (2)
Lehtimäki, Terho (2)
Johansson, Åsa (2)
Tuomilehto, Jaakko (2)
Verweij, Niek (2)
Rotter, Jerome I. (2)
Mangino, Massimo (2)
Willemsen, Gonneke (2)
Oostra, Ben A. (2)
Gieger, Christian (2)
Peters, Annette (2)
Martin, Nicholas G. (2)
Boomsma, Dorret I. (2)
Spector, Tim D. (2)
Samani, Nilesh J. (2)
Jarvelin, Marjo-Riit ... (2)
Knekt, Paul (2)
Mahajan, Anubha (2)
Luan, Jian'an (2)
Metspalu, Andres (2)
Caulfield, Mark J. (2)
Farrall, Martin (2)
Munroe, Patricia B. (2)
Palmer, Colin N. A. (2)
Hicks, Andrew A. (2)
Pramstaller, Peter P ... (2)
Wright, Alan F. (2)
Wilson, James F. (2)
Nalls, Michael A. (2)
Schmidt, Reinhold (2)
Schmidt, Helena (2)
Deary, Ian J (2)
Montgomery, Grant W. (2)
visa färre...
Lärosäte
Uppsala universitet (3)
Karolinska Institutet (3)
Umeå universitet (2)
Lunds universitet (2)
Göteborgs universitet (1)
Stockholms universitet (1)
visa fler...
Högskolan Dalarna (1)
visa färre...
Språk
Engelska (3)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (3)
Naturvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy