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Breast cancer risk and 6q22.33 combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Kirchhoff, Tomas (author)
Gaudet, Mia M (author)
Antoniou, Antonis C (author)
show more...
McGuffog, Lesley (author)
Humphreys, Manjeet K (author)
Dunning, Alison M (author)
Bojesen, Stig E (author)
Nordestgaard, Børge G (author)
Flyger, Henrik (author)
Kang, Daehee (author)
Yoo, Keun-Young (author)
Noh, Dong-Young (author)
Ahn, Sei-Hyun (author)
Dork, Thilo (author)
Schürmann, Peter (author)
Karstens, Johann H (author)
Hillemanns, Peter (author)
Couch, Fergus J (author)
Olson, Janet (author)
Vachon, Celine (author)
Wang, Xianshu (author)
Cox, Angela (author)
Brock, Ian (author)
Elliott, Graeme (author)
Reed, Malcolm W R (author)
Burwinkel, Barbara (author)
Meindl, Alfons (author)
Brauch, Hiltrud (author)
Hamann, Ute (author)
Ko, Yon-Dschun (author)
Broeks, Annegien (author)
Schmidt, Marjanka K (author)
Van 't Veer, Laura J (author)
Braaf, Linde M (author)
Johnson, Nichola (author)
Fletcher, Olivia (author)
Gibson, Lorna (author)
Peto, Julian (author)
Turnbull, Clare (author)
Seal, Sheila (author)
Renwick, Anthony (author)
Rahman, Nazneen (author)
Wu, Pei-Ei (author)
Yu, Jyh-Cherng (author)
Hsiung, Chia-Ni (author)
Shen, Chen-Yang (author)
Southey, Melissa C (author)
Hopper, John L (author)
Hammet, Fleur (author)
Van Dorpe, Thijs (author)
Dieudonne, Anne-Sophie (author)
Hatse, Sigrid (author)
Lambrechts, Diether (author)
Andrulis, Irene L (author)
Bogdanova, Natalia (author)
Antonenkova, Natalia (author)
Rogov, Juri I (author)
Prokofieva, Daria (author)
Bermisheva, Marina (author)
Khusnutdinova, Elza (author)
van Asperen, Christi J (author)
Tollenaar, Robert A E M (author)
Hooning, Maartje J (author)
Devilee, Peter (author)
Margolin, Sara (author)
Lindblom, Annika (author)
Milne, Roger L (author)
Arias, José Ignacio (author)
Zamora, M Pilar (author)
Benítez, Javier (author)
Severi, Gianluca (author)
Baglietto, Laura (author)
Giles, Graham G (author)
Spurdle, Amanda B (author)
Beesley, Jonathan (author)
Chen, Xiaoqing (author)
Holland, Helene (author)
Healey, Sue (author)
Wang-Gohrke, Shan (author)
Chang-Claude, Jenny (author)
Mannermaa, Arto (author)
Kosma, Veli-Matti (author)
Kauppinen, Jaana (author)
Kataja, Vesa (author)
Agnarsson, Bjarni A (author)
Caligo, Maria A (author)
Godwin, Andrew K (author)
Nevanlinna, Heli (author)
Heikkinen, Tuomas (author)
Fredericksen, Zachary (author)
Lindor, Noralane (author)
Nathanson, Katherine L (author)
Domchek, Susan M (author)
Loman, Niklas (author)
Karlsson, Per (author)
Stenmark Askmalm, Marie (author)
Melin, Beatrice (author)
von Wachenfeldt, Anna (author)
Hogervorst, Frans B L (author)
Verheus, Martijn (author)
Rookus, Matti A (author)
Seynaeve, Caroline (author)
Oldenburg, Rogier A (author)
Ligtenberg, Marjolijn J (author)
Ausems, Margreet G E M (author)
Aalfs, Cora M (author)
Gille, Hans J P (author)
Wijnen, Juul T (author)
Gómez García, Encarna B (author)
Peock, Susan (author)
Cook, Margaret (author)
Oliver, Clare T (author)
Frost, Debra (author)
Luccarini, Craig (author)
Pichert, Gabriella (author)
Davidson, Rosemarie (author)
Chu, Carol (author)
Eccles, Diana (author)
Ong, Kai-Ren (author)
Cook, Jackie (author)
Douglas, Fiona (author)
Hodgson, Shirley (author)
Evans, D Gareth (author)
Eeles, Rosalind (author)
Gold, Bert (author)
Pharoah, Paul D P (author)
Offit, Kenneth (author)
Chenevix-Trench, Georgia (author)
Easton, Douglas F (author)
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 (publisher)
Public library of science 2012
2012
English.
In: PLoS ONE. - 1932-6203. ; 7:6
  • swepub:Mat__t
Abstract Subject headings
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  • Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.

Subject headings

Medical and Health Sciences  (hsv)
Clinical Medicine  (hsv)
Cancer and Oncology  (hsv)
Medicin och hälsovetenskap  (hsv)
Klinisk medicin  (hsv)
Cancer och onkologi  (hsv)

Keyword

genome-wide association
susceptibility loci
variants
alleles
FGFR2
gene

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By the author/editor
Kirchhoff, Tomas
Gaudet, Mia M
Antoniou, Antoni ...
McGuffog, Lesley
Humphreys, Manje ...
Dunning, Alison ...
show more...
Bojesen, Stig E
Nordestgaard, Bø ...
Flyger, Henrik
Kang, Daehee
Yoo, Keun-Young
Noh, Dong-Young
Ahn, Sei-Hyun
Dork, Thilo
Schürmann, Peter
Karstens, Johann ...
Hillemanns, Pete ...
Couch, Fergus J
Olson, Janet
Vachon, Celine
Wang, Xianshu
Cox, Angela
Brock, Ian
Elliott, Graeme
Reed, Malcolm W ...
Burwinkel, Barba ...
Meindl, Alfons
Brauch, Hiltrud
Hamann, Ute
Ko, Yon-Dschun
Broeks, Annegien
Schmidt, Marjank ...
Van 't Veer, Lau ...
Braaf, Linde M
Johnson, Nichola
Fletcher, Olivia
Gibson, Lorna
Peto, Julian
Turnbull, Clare
Seal, Sheila
Renwick, Anthony
Rahman, Nazneen
Wu, Pei-Ei
Yu, Jyh-Cherng
Hsiung, Chia-Ni
Shen, Chen-Yang
Southey, Melissa ...
Hopper, John L
Hammet, Fleur
Van Dorpe, Thijs
Dieudonne, Anne- ...
Hatse, Sigrid
Lambrechts, Diet ...
Andrulis, Irene ...
Bogdanova, Natal ...
Antonenkova, Nat ...
Rogov, Juri I
Prokofieva, Dari ...
Bermisheva, Mari ...
Khusnutdinova, E ...
van Asperen, Chr ...
Tollenaar, Rober ...
Hooning, Maartje ...
Devilee, Peter
Margolin, Sara
Lindblom, Annika
Milne, Roger L
Arias, José Igna ...
Zamora, M Pilar
Benítez, Javier
Severi, Gianluca
Baglietto, Laura
Giles, Graham G
Spurdle, Amanda ...
Beesley, Jonatha ...
Chen, Xiaoqing
Holland, Helene
Healey, Sue
Wang-Gohrke, Sha ...
Chang-Claude, Je ...
Mannermaa, Arto
Kosma, Veli-Matt ...
Kauppinen, Jaana
Kataja, Vesa
Agnarsson, Bjarn ...
Caligo, Maria A
Godwin, Andrew K
Nevanlinna, Heli
Heikkinen, Tuoma ...
Fredericksen, Za ...
Lindor, Noralane
Nathanson, Kathe ...
Domchek, Susan M
Loman, Niklas
Karlsson, Per
Stenmark Askmalm ...
Melin, Beatrice
von Wachenfeldt, ...
Hogervorst, Fran ...
Verheus, Martijn
Rookus, Matti A
Seynaeve, Caroli ...
Oldenburg, Rogie ...
Ligtenberg, Marj ...
Ausems, Margreet ...
Aalfs, Cora M
Gille, Hans J P
Wijnen, Juul T
Gómez García, En ...
Peock, Susan
Cook, Margaret
Oliver, Clare T
Frost, Debra
Luccarini, Craig
Pichert, Gabriel ...
Davidson, Rosema ...
Chu, Carol
Eccles, Diana
Ong, Kai-Ren
Cook, Jackie
Douglas, Fiona
Hodgson, Shirley
Evans, D Gareth
Eeles, Rosalind
Gold, Bert
Pharoah, Paul D ...
Offit, Kenneth
Chenevix-Trench, ...
Easton, Douglas ...
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