| 1. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 2. |
- Xu, Fang, et al.
(författare)
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Synthesis, structure-activity relationship and biological evaluation of novel arylpiperzines as alpha(1A/1D)-AR subselective antagonists for BPH
- 2015
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Ingår i: Bioorganic & Medicinal Chemistry. - : Elsevier. - 0968-0896 .- 1464-3391. ; 23:24, s. 7735-7742
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Tidskriftsartikel (refereegranskat)abstract
- A series of novel arylpiperazine derivatives as alpha(1A/1D)-adrenergic receptors (AR) subtype selective antagonists were designed, synthesized and evaluated for their antagonistic activities towards alpha(1)-ARs (alpha(1A), alpha(1B), and alpha(1D)). Compounds 9, 12, 13, 15, 17, 18, 21, 22, 25 and 26 exerted strong antagonistic effects on alpha(1A) and/or alpha(1D) subtypes over alpha(1B) in vitro. SAR analysis indicated that chloride at the ortho-phenyl position for compound 17 was beneficial for the highest alpha(1A/D)-AR sub-selectivity. Moreover, molecular docking study of compound 17 with the homology-modeled alpha(1)-ARs (alpha(1A), alpha(1B), and alpha(1D)) structures exhibited differences of key amino resides in the docking pocket which may influence the subtype selectivity. ILE 193 of alpha(1A) was validated as the key residues for binding ligand. This work provides useful information for finding more new potential drugs in clinic in treating benign prostatic hyperplasia (BPH).
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| 3. |
- Kang, Kai, et al.
(författare)
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Auction-based cloud service allocation and sharing for logistics product service system
- 2021
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Ingår i: Journal of Cleaner Production. - : Elsevier Ltd. - 0959-6526 .- 1879-1786. ; 278
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Tidskriftsartikel (refereegranskat)abstract
- Sustainability is increasingly viewed as a desired goal of social development. The logistics industry without exception is aware of the importance of sustainable development. To achieve this goal, the logistics industry is leveraging cutting-edge technologies, such as product service systems (PSS) and cloud manufacturing (CMfg), to design logistics product service systems (LPSS). In LPSS, public logistics resources are allocated to customers and private logistics resources are shared between customers. However, logistics resource allocation and sharing services have been impeded by a lack of efficient methods. In this context, this paper proposes an auction-based cloud service allocation and sharing method for LPSS. Firstly, LPSS is defined and elaborated based on the adoption of PSS in the logistics industry. Secondly, multi-unit Vickery (MV) auctions and one-sided Vickrey-Clarke-Groves (O-VCG) combinatorial auctions are proposed to address logistics resource allocation and sharing problems respectively in LPSS. Two auctions are introduced specifically, and their relevant properties are investigated, including incentive compatibility, allocative efficiency, budget balance, and individual rationality. Thirdly, computational studies are conducted to examine the performance of two auctions. The results reveal that MV auctions can efficiently allocate public logistics resources through ensuring the utility of logistics service providers under dynamic supply and demand. Additionally, O-VCG auctions can effectively integrate and share idle private logistics resources, which promotes sustainability in the logistics industry. Through integrating MV auctions with O-VCG auctions, the utility of logistics service providers can be increased.
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| 4. |
- Shao, Wen-Ze, et al.
(författare)
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On potentials of regularized Wasserstein generative adversarial networks for realistic hallucination of tiny faces
- 2019
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Ingår i: Neurocomputing. - : ELSEVIER. - 0925-2312 .- 1872-8286. ; 364, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Super-resolution of facial images, a.k.a. face hallucination, has been intensively studied in the past decades due to the increasingly emerging analysis demands in video surveillance, e.g., face detection, verification, identification. However, the actual performance of most previous hallucination approaches will drop dramatically when a very low-res tiny face is provided, due to the challenging multimodality of the problem as well as lack of an informative prior as a strong semantic guidance. Inspired by the latest progress in deep unsupervised learning, this paper focuses on tiny faces of size 16 x 16 pixels, hallucinating them to their 8 x upsampling versions by exploring the potentials of Wasserstein generative adversarial networks (WGAN). Besides a pixel-wise L2 regularization term imposed to the generative model, it is found that our advocated autoencoding generator with both residual and skip connections is a critical component for WGAN representing the facial contour and semantic content to a reasonable precision. With the additional Lipschitz penalty and architectural considerations for the critic in WGAN, the proposed approach finally achieves state-of-the-art hallucination performance in terms of both visual perception and objective assessment. The cropped CelebA face dataset is primarily used to aid the tuning and analysis of the new method, termed as tfh-WGAN. Experimental results demonstrate that the proposed approach not only achieves realistic hallucination of tiny faces, but also adapts to pose, expression, illuminance and occluded variations to a great degree.
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| 5. |
- Wang, Linqin, et al.
(författare)
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Design and synthesis of dopant-free organic hole-transport materials for perovskite solar cells
- 2018
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Ingår i: Chemical Communications. - : ROYAL SOC CHEMISTRY. - 1359-7345 .- 1364-548X. ; 54:69, s. 9571-9574
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Tidskriftsartikel (refereegranskat)abstract
- Two novel dopant-free hole-transport materials (HTMs) with spiro[dibenzo[c,h]xanthene-7,9-fluorene] (SDBXF) skeletons were prepared via facile synthesis routes. A power conversion efficiency of 15.9% in perovskite solar cells is attained by using one HTM without dopants, which is much higher than undoped Spiro-OMeTAD-based devices (10.8%). The crystal structures of both new HTMs were systematically investigated to reveal the reasons behind such differences in performance and to indicate the design principles of more advanced HTMs.
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| 6. |
- Xiong, Dehua, et al.
(författare)
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Enhanced Performance of p-Type Dye-Sensitized Solar Cells Based on Ultrasmall Mg-Doped CuCrO2 Nanocrystals
- 2013
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Ingår i: ChemSusChem. - : Wiley. - 1864-5631 .- 1864-564X. ; 6:8, s. 1432-1437
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Tidskriftsartikel (refereegranskat)abstract
- Herein, we present ultrasmall delafossite-type Mg-doped CuCrO2 nanocrystals prepared by using hydrothermal synthesis and their first application as photocathodes in efficient p-type dye-sensitized solar cells. The short-circuit current density (J(sc)) is notably increased by approximately 27% owing to the decreased crystallite size and the enhanced optical transmittance associated with Mg doping of the CuCrO2 nanocrystalline sample. An open-circuit voltage (V-oc) of 201mV, J(sc) of 1.51mAcm(-2), fill factor of 0.449, and overall photoconversion efficiency of 0.132% have been achieved with the CuCr0.9Mg0.1O2 dye photocathode sensitized with the P1 dye under optimized conditions. This efficiency is nearly threetimes higher than that of the NiO-based reference device, which is attributed to the largely improved V-oc and J(sc). The augmentation of V-oc and J(sc) can be attributed to the lower valance band position and the faster hole diffusion coefficient of CuCr0.9Mg0.1O2 compared to those of the NiO reference, respectively, which leads to a higher hole collection efficiency.
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| 7. |
- Zhang, Jinbao, et al.
(författare)
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Chemical Dopant Engineering in Hole Transport Layers for Efficient Perovskite Solar Cells : Insight into the Interfacial Recombination
- 2018
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Ingår i: ACS Nano. - : American Chemical Society (ACS). - 1936-0851 .- 1936-086X. ; 12:10, s. 10452-10462
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Tidskriftsartikel (refereegranskat)abstract
- Chemical doping of organic semiconductors has been recognized as an effective way to enhance the electrical conductivity. In perovskite solar cells (PSCs), various types of dopants have been developed for organic hole transport materials (HTMs); however, the knowledge of the basic requirements for being efficient dopants as well as the comprehensive roles of the dopants in PSCs has not been clearly revealed. Here, three copper-based complexes with controlled redox activities are applied as dopants in PSCs, and it is found that the oxidative reactivity of dopants presents substantial impacts on conductivity, charge dynamics, and solar cell performance. A significant improvement of open- circuit voltage (V-oc) by more than 100 mV and an increase of power conversion efficiency from 13.2 to 19.3% have been achieved by tuning the doping level of the HTM. The observed large variation of V-oc for three dopants reveals their different recombination kinetics at the perovskite/HTM interfaces and suggests a model of an interfacial recombination mechanism. We also suggest that the dopants in HTMs can also affect the charge recombination kinetics as well as the solar cell performance. Based on these findings, a strategy is proposed to physically passivate the electron- hole recombination by inserting an ultrathin Al2O3 insulating layer between the perovskite and the HTM. This strategy contributes a significant enhancement of the power conversion efficiency and environmental stability, indicating that dopant engineering is one crucial way to further improve the performance of PSCs.
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| 8. |
- Zhang, Jian, et al.
(författare)
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Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and-2 Influenza A Neuraminidases, Including a Drug-Resistant Variant
- 2018
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 61:14, s. 6379-6397
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Tidskriftsartikel (refereegranskat)abstract
- On the basis of our earlier discovery of N1-selective inhibitors, the 150-cavity of influenza virus neuraminidases (NAs) could be further exploited to yield more potent oseltamivir derivatives. Among the synthesized compounds, 15b and 15c were exceptionally active against both group-1 and -2 NAs. Especially for 09N1, N2, N6, and N9 subtypes, they showed 6.80-12.47 and 1.20-3.94 times greater activity than oseltamivir carboxylate (OSC). They also showed greater inhibitory activity than OSC toward H274Y and E119V variant. In cellular assays, they exhibited greater potency than OSC toward H5N1, H5N2, H5N6, and H5N8 viruses. 15b demonstrated high metabolic stability, low cytotoxicity in vitro, and low acute toxicity in mice. Computational modeling and molecular dynamics studies provided insights into the role of R group of 15b in improving potency toward group-1 and -2 NAs. We believe the successful exploitation of the 150-cavity of NAs represents an important breakthrough in the development of more potent anti-influenza agents.
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